{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T06:57:34Z","timestamp":1791097054503,"version":"4.1.0"},"reference-count":19,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2000,9,1]],"date-time":"2000-09-01T00:00:00Z","timestamp":967766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2000,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Therapeutic responses to clindamycin in combination with quinine were assessed in adult Thai patients with uncomplicated multidrug-resistant\n            <jats:italic>Plasmodium falciparum<\/jats:italic>\n            malaria. In total 204 patients were randomized to receive a 7-day oral treatment regimen of quinine (Q\n            <jats:sub>7<\/jats:sub>\n            ) either alone (\n            <jats:italic>n<\/jats:italic>\n            = 68), in combination with clindamycin (Q\n            <jats:sub>7<\/jats:sub>\n            C\n            <jats:sub>7<\/jats:sub>\n            ;\n            <jats:italic>n<\/jats:italic>\n            = 68), or in combination with tetracycline (Q\n            <jats:sub>7<\/jats:sub>\n            T\n            <jats:sub>7<\/jats:sub>\n            ;\n            <jats:italic>n<\/jats:italic>\n            = 68). All patients had uncomplicated recoveries with no serious adverse effects. Fever clearance times for both of the two combination regimens (median of 47 h and range of 8 to 120 h for Q\n            <jats:sub>7<\/jats:sub>\n            C\n            <jats:sub>7<\/jats:sub>\n            and median of 36 h and range of 8 to 117 h for Q\n            <jats:sub>7<\/jats:sub>\n            T\n            <jats:sub>7<\/jats:sub>\n            ) were significantly shorter than that for the Q\n            <jats:sub>7<\/jats:sub>\n            -only regimen (median, 56; range, 4 to 152 h) (\n            <jats:italic>P<\/jats:italic>\n            = 0.002). Parasite clearance times (overall mean \u00b1 standard deviation, 78 \u00b1 23 h) were not significantly different between the three treatment groups (\n            <jats:italic>P<\/jats:italic>\n            = 0.98). The cure rates assessed at 28 days of follow-up were 100% for Q\n            <jats:sub>7<\/jats:sub>\n            C\n            <jats:sub>7<\/jats:sub>\n            and 98% for Q\n            <jats:sub>7<\/jats:sub>\n            T\n            <jats:sub>7<\/jats:sub>\n            , whereas the cure rate was 87% for the Q\n            <jats:sub>7<\/jats:sub>\n            -only regimen (\n            <jats:italic>P<\/jats:italic>\n            \u2264 0.04). Clindamycin in combination with quinine is a safe and effective treatment for multidrug-resistant\n            <jats:italic>P. falciparum<\/jats:italic>\n            malaria. This combination may be of particular value in children and pregnant women, in whom tetracyclines are contraindicated.\n          <\/jats:p>","DOI":"10.1128\/aac.44.9.2395-2398.2000","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:56:57Z","timestamp":1027763817000},"page":"2395-2398","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":58,"title":["Therapeutic Responses to Quinine and Clindamycin in Multidrug-Resistant Falciparum Malaria"],"prefix":"10.1128","volume":"44","author":[{"given":"Sasithon","family":"Pukrittayakamee","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Department of Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand1;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Chantra","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand1;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirivan","family":"Vanijanonta","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand1;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Clemens","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand1;"},{"name":"<!--label omitted: 2-->SmithKline Beecham, Collegeville, Pennsylvania2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sornchai","family":"Looareesuwan","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand1;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"White","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand1;"},{"name":"<!--label omitted: 3-->Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford, United Kingdom3; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1080\/02724936.1981.11748054","article-title":"In vivo and in vitro sensitivity of falciparum malaria to quinine in Thai children.","volume":"1","author":"Chongsuphajaisiddhi T.","year":"1981","unstructured":"Chongsuphajaisiddhi T. 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