{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T04:40:13Z","timestamp":1771476013524,"version":"3.50.1"},"reference-count":30,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2000,9,1]],"date-time":"2000-09-01T00:00:00Z","timestamp":967766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2000,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Sodium stibogluconate (Sbb), a leishmanicidal drug, was studied for its in vivo effect on the formation of reactive oxygen species (ROS), assessed by chemiluminescence (CL) in the whole blood of mice infected with<jats:italic>Leishmania infantum<\/jats:italic>. Stimulation of ROS formation induced ex vivo by zymosan particles or the protein kinase C activator phorbol myristate acetate (PMA) was reduced by approximately 25% (<jats:italic>P<\/jats:italic>&lt; 0.05) after infection of mice. Treatment of infected mice with Sbb (50 to 400 mg\/kg of body weight) enhanced the blood CL induced by zymosan and PMA (47 to 96%,<jats:italic>P<\/jats:italic>&lt; 0.01). The drug potentiation effect also occurred in uninfected mice. In vitro treatment of normal human blood with Sbb (1, 10, or 100 \u03bcg\/ml) for 1 h primed the CL response to PMA (29 to 54%). The priming effect of Sbb was also observed on the production of superoxide by isolated polymorphonuclear leukocytes stimulated either by PMA and zymosan or by the chemoattractants<jats:italic>N<\/jats:italic>-formyl-Met-Leu-Phe and platelet-activating factor. These data provide the first evidence of priming of the phagocyte respiratory burst by Sbb. This novel property of Sbb may contribute to the drug's leishmanicidal effect.<\/jats:p>","DOI":"10.1128\/aac.44.9.2406-2410.2000","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:06:42Z","timestamp":1027764402000},"page":"2406-2410","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":38,"title":["Sodium Stibogluconate (Pentostam) Potentiates Oxidant Production in Murine Visceral Leishmaniasis and in Human Blood"],"prefix":"10.1128","volume":"44","author":[{"given":"Samira","family":"Rais","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Service de Parasitologie, Faculte\u0301 de Me\u0301decine,1 and"},{"name":"<!--label omitted: 2-->Laboratoire de Biochimie, Faculte\u0301 des Sciences Ben M'sik, Casablanca,2 Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Axel","family":"Perianin","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->CNRS UPRES-A 8068, Pharmacologie, Ho\u0302pital Cochin, 75014 Paris,3 France, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monique","family":"Lenoir","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->CNRS UPRES-A 8068, Pharmacologie, Ho\u0302pital Cochin, 75014 Paris,3 France, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abderrahim","family":"Sadak","sequence":"additional","affiliation":[{"name":"<!--label omitted: 4-->Laboratoire de Parasitologie, Faculte\u0301 des Sciences, Rabat,4 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Rivollet","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Service de Parasitologie, Faculte\u0301 de Me\u0301decine,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muriel","family":"Paul","sequence":"additional","affiliation":[{"name":"<!--label omitted: 5-->Service de Pharmacie,5 CHU Henri Mondor, 94010 Cre\u0301teil, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Deniau","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Service de Parasitologie, Faculte\u0301 de Me\u0301decine,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(86)33085-4"},{"key":"e_1_3_2_3_2","first-page":"279","article-title":"Effect of Leishmania major on luminol-dependent chemiluminescence of human whole blood phagocytosis.","volume":"40","author":"al-Mofleh I. A.","year":"1989","unstructured":"al-Mofleh I. A. Mahmoud A. A. al-Khuwaiter A. S. al-Tuwaijri A. S. Effect of Leishmania major on luminol-dependent chemiluminescence of human whole blood phagocytosis. Trop. Med. Parasitol. 40 1989 279 284","journal-title":"Trop. Med. Parasitol."},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1099\/00222615-32-3-189","article-title":"Effect of Leishmania major on human polymorphonuclear leucocyte function in vitro.","volume":"32","author":"al Tuwaijri A. S.","year":"1990","unstructured":"al Tuwaijri A. S. al Mofleh I. A. Mahmoud A. A. Effect of Leishmania major on human polymorphonuclear leucocyte function in vitro. J. Med. Microbiol. 32 1990 189 193","journal-title":"J. Med. Microbiol."},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197803232981205"},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/0035-9203(89)90327-1","article-title":"Concentration of Pentostam in human breast milk.","volume":"83","author":"Berman J. D.","year":"1989","unstructured":"Berman J. D. Melby P. C. Neva F. A. Concentration of Pentostam in human breast milk. Trans. R. Soc. Trop. Med. Hyg. 83 1989 784 785","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.27.6.916"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V86.5.1649.bloodjournal8651649"},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1172\/JCI113969","article-title":"Antigen-specific immunosuppression in visceral leishmaniasis is cell mediated.","volume":"83","author":"Carvalho E. M.","year":"1989","unstructured":"Carvalho E. M. Bacellar O. Barral A. Badaro R. Johnson W. D. Jr. Antigen-specific immunosuppression in visceral leishmaniasis is cell mediated. J. Clin. Investig. 83 1989 860 864","journal-title":"J. Clin. Investig."},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(88)90267-2"},{"key":"e_1_3_2_11_2","doi-asserted-by":"crossref","first-page":"2890","DOI":"10.1182\/blood.V82.9.2890.2890","article-title":"Stimulation of the human neutrophil respiratory burst by formyl peptides is primed by a protein kinase inhibitor, staurosporine.","volume":"82","author":"Combadiere C.","year":"1993","unstructured":"Combadiere C. el Benna J. Pedruzzi E. Hakim J. Perianin A. Stimulation of the human neutrophil respiratory burst by formyl peptides is primed by a protein kinase inhibitor, staurosporine. Blood 82 1993 2890 2898","journal-title":"Blood"},{"key":"e_1_3_2_12_2","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0006-291X(90)91675-I","article-title":"Staurosporine, a protein kinase inhibitor, up-regulates the stimulation of human neutrophil respiratory burst by N-formyl peptides and platelet activating factor.","volume":"168","author":"Combadiere C.","year":"1990","unstructured":"Combadiere C. Hakim J. Giroud J. P. Perianin A. Staurosporine, a protein kinase inhibitor, up-regulates the stimulation of human neutrophil respiratory burst by N-formyl peptides and platelet activating factor. Biochem. Biophys. Res. Commun. 168 1990 65 70","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"e_1_3_2_13_2","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0922-4106(95)90194-9","article-title":"Contrasting effects of calyculin A and okadaic acid on the respiratory burst of human neutrophils.","volume":"288","author":"Djerdjouri B.","year":"1995","unstructured":"Djerdjouri B. Combadiere C. Pedruzzi E. Hakim J. Perianin A. Contrasting effects of calyculin A and okadaic acid on the respiratory burst of human neutrophils. Eur. J. Pharmacol. 288 1995 193 200","journal-title":"Eur. J. Pharmacol."},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1006\/bbrc.1994.2832","article-title":"Okadaic acid, an inhibitor of type 1 and type 2A phosphatases, modulates the activation of phospholipase D in formyl peptide- and mastoparan-stimulated human neutrophils.","volume":"205","author":"Djerdjouri B.","year":"1994","unstructured":"Djerdjouri B. Pedruzzi E. Hakim J. Perianin A. Okadaic acid, an inhibitor of type 1 and type 2A phosphatases, modulates the activation of phospholipase D in formyl peptide- and mastoparan-stimulated human neutrophils. Biochem. Biophys. Res. Commun. 205 1994 1481 1487","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"e_1_3_2_15_2","first-page":"264","article-title":"Neutrophil priming: the cellular signals that say 'amber' but not 'green.' Immunol.","volume":"16","author":"Hallett M. B.","year":"1995","unstructured":"Hallett M. B. Lloyds D. Neutrophil priming: the cellular signals that say 'amber' but not 'green.' Immunol. Today 16 1995 264 268","journal-title":"Today"},{"key":"e_1_3_2_16_2","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1084\/jem.181.4.1493","article-title":"Neutrophils from human immunodeficiency virus (HIV)-seronegative donors induce HIV replication from HIV-positive patients' mononuclear cells and cell lines: an in vitro model of HIV transmission facilitated by Chlamydia trachomatis.","volume":"181","author":"Ho J.","year":"1995","unstructured":"Ho J. He S. Hu A. Geng J. Basile F. Almeida M. Saito A. Laurence J. Johnson W. J. Neutrophils from human immunodeficiency virus (HIV)-seronegative donors induce HIV replication from HIV-positive patients' mononuclear cells and cell lines: an in vitro model of HIV transmission facilitated by Chlamydia trachomatis. J. Exp. Med. 181 1995 1493 1505","journal-title":"J. Exp. Med."},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.60.5.1984-1993.1992"},{"key":"e_1_3_2_18_2","first-page":"207","article-title":"Immunosuppression in Kenyan visceral leishmaniasis.","volume":"51","author":"Ho M.","year":"1983","unstructured":"Ho M. Koech D. K. Iha D. W. Bryceson A. D. Immunosuppression in Kenyan visceral leishmaniasis. Clin. Exp. Immunol. 51 1983 207 214","journal-title":"Clin. Exp. Immunol."},{"key":"e_1_3_2_19_2","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/pd.1970070405","article-title":"Prenatal diagnosis of chronic granulomatous disease (CGD) in four high risk male fetuses.","volume":"7","author":"Huu T. P.","year":"1987","unstructured":"Huu T. P. Dumez Y. Marquetty C. Durandy A. Boue J. Hakim J. Prenatal diagnosis of chronic granulomatous disease (CGD) in four high risk male fetuses. Prenatal Diagn. 7 1987 253 260","journal-title":"Prenatal Diagn."},{"key":"e_1_3_2_20_2","doi-asserted-by":"crossref","first-page":"23554","DOI":"10.1016\/S0021-9258(18)35874-5","article-title":"A protein kinase C inhibitor, staurosporine, activates phospholipase D via a pertussis toxin-sensitive GTP-binding protein in rabbit peritoneal neutrophils.","volume":"267","author":"Kanaho Y.","year":"1992","unstructured":"Kanaho Y. Takahashi K. Tomita U. Iiri T. Katada T. Ui M. Nozawa Y. A protein kinase C inhibitor, staurosporine, activates phospholipase D via a pertussis toxin-sensitive GTP-binding protein in rabbit peritoneal neutrophils. J. Biol. Chem. 267 1992 23554 23559","journal-title":"J. Biol. Chem."},{"key":"e_1_3_2_21_2","doi-asserted-by":"crossref","first-page":"4794","DOI":"10.4049\/jimmunol.144.12.4794","article-title":"Macrophage killing of Leishmania parasite in vivo is mediated by nitric oxide from l-arginine.","volume":"144","author":"Liew F. Y.","year":"1990","unstructured":"Liew F. Y. Millott S. Parkinson C. Palmer R. M. Moncada S. Macrophage killing of Leishmania parasite in vivo is mediated by nitric oxide from l-arginine. J. Immunol. 144 1990 4794 4797","journal-title":"J. Immunol."},{"key":"e_1_3_2_22_2","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0165-2478(98)00099-6","article-title":"The role of polymorphonuclear leukocytes in the resistance to cutaneous leishmaniasis.","volume":"64","author":"Lima G. M.","year":"1998","unstructured":"Lima G. M. Vallochi A. L. Silva U. R. Bevilacqua E. M. Kiffer M. M. Abrahamsohn I. A. The role of polymorphonuclear leukocytes in the resistance to cutaneous leishmaniasis. Immunol. Lett. 64 1998 145 151","journal-title":"Immunol. Lett."},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.189.4.741"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.8.1731"},{"key":"e_1_3_2_25_2","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0014-5793(93)81127-L","article-title":"Staurosporine stimulates phospholipase D activation in human polymorphonuclear leukocytes.","volume":"315","author":"Perianin A.","year":"1993","unstructured":"Perianin A. Combadiere C. Pedruzzi E. Djerdjouri B. Hakim J. Staurosporine stimulates phospholipase D activation in human polymorphonuclear leukocytes. FEBS Lett. 315 1993 33 37","journal-title":"FEBS Lett."},{"key":"e_1_3_2_26_2","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0014-5793(94)80487-7","article-title":"W-7, a calmodulin antagonist, primes the stimulation of human neutrophil respiratory burst by formyl peptides and platelet-activating factor.","volume":"342","author":"Perianin A.","year":"1994","unstructured":"Perianin A. Pedruzzi E. Hakim J. W-7, a calmodulin antagonist, primes the stimulation of human neutrophil respiratory burst by formyl peptides and platelet-activating factor. FEBS Lett. 342 1994 135 138","journal-title":"FEBS Lett."},{"key":"e_1_3_2_27_2","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0898-6568(97)00116-2","article-title":"Priming of phosphatidic acid production by staurosporine in f-Met-Leu-Phe-stimulated human neutrophils\u2014correlation with respiratory burst.","volume":"10","author":"Rais S.","year":"1998","unstructured":"Rais S. Pedruzzi E. Dang M. C. Giroud J. P. Hakim J. Perianin A. Priming of phosphatidic acid production by staurosporine in f-Met-Leu-Phe-stimulated human neutrophils\u2014correlation with respiratory burst. Cell. Signal. 10 1998 121 129","journal-title":"Cell. Signal."},{"key":"e_1_3_2_28_2","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/0014-4894(89)90120-3","article-title":"The role of TH1 and TH2 cells in experimental cutaneous leishmaniasis.","volume":"68","author":"Scott P.","year":"1989","unstructured":"Scott P. The role of TH1 and TH2 cells in experimental cutaneous leishmaniasis. Exp. Parasitol. 68 1989 369 372","journal-title":"Exp. Parasitol."},{"key":"e_1_3_2_29_2","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1550-7408.1958.tb02565.x","article-title":"An eight day method for screening compounds against Leishmania donovani in golden hamster.","volume":"5","author":"Stauber L. A.","year":"1958","unstructured":"Stauber L. A. Franchino E. M. Grun J. An eight day method for screening compounds against Leishmania donovani in golden hamster. J. Protozool. 5 1958 269 273","journal-title":"J. Protozool."},{"key":"e_1_3_2_30_2","first-page":"333","article-title":"Chemiluminescence of whole blood. II. Application to clinical examination of phagocytic functions of whole blood from various types of disease.","volume":"29","author":"Tono-oka T.","year":"1983","unstructured":"Tono-oka T. Matsumoto T. Ueno N. Yashiki N. Matsumoto S. Chemiluminescence of whole blood. II. Application to clinical examination of phagocytic functions of whole blood from various types of disease. Clin. Immunol. Immunopathol. 29 1983 333 340","journal-title":"Clin. Immunol. Immunopathol."},{"key":"e_1_3_2_31_2","doi-asserted-by":"crossref","first-page":"7804","DOI":"10.1073\/pnas.92.17.7804","article-title":"The killing of Leishmania major by human macrophages is mediated by nitric oxide induced after ligation of the Fc epsilon RII\/CD23 surface antigen.","volume":"92","author":"Vouldoukis I.","year":"1995","unstructured":"Vouldoukis I. Riveros-Moreno V. Dugas B. Ouaaz F. Becherel P. Debre P. Moncada S. Mossalayi M. D. The killing of Leishmania major by human macrophages is mediated by nitric oxide induced after ligation of the Fc epsilon RII\/CD23 surface antigen. Proc. Natl. Acad. Sci. USA 92 1995 7804 7808","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.44.9.2406-2410.2000","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.44.9.2406-2410.2000","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,23]],"date-time":"2023-04-23T15:52:11Z","timestamp":1682265131000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.44.9.2406-2410.2000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,9]]},"references-count":30,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2000,9]]}},"alternative-id":["10.1128\/AAC.44.9.2406-2410.2000"],"URL":"https:\/\/doi.org\/10.1128\/aac.44.9.2406-2410.2000","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,9]]},"assertion":[{"value":"2000-02-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-06-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}