{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:48:29Z","timestamp":1787759309119,"version":"build-2784847793"},"reference-count":27,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2001,10,1]],"date-time":"2001-10-01T00:00:00Z","timestamp":1001894400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2001,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Ertapenem (MK-0826; L-749,345), a new carbapenem with a long serum half-life, was tested, in vitro, against \u03b2-lactamase-producing bacteria. The new compound had a MIC at which 90% of the isolates were inhibited of 0.06 \u03bcg\/ml for extended-spectrum \u03b2-lactamase (ESBL)-producing klebsiellas, compared with 0.5 \u03bcg\/ml for imipenem, 16 \u03bcg\/ml for cefepime, and &gt;128 \u03bcg\/ml for ceftazidime and piperacillin-tazobactam. MICs of ertapenem for AmpC-derepressed mutant\n            <jats:italic>Enterobacteriaceae<\/jats:italic>\n            were 0.015 to 0.5 \u03bcg\/ml, whereas imipenem MICs were 0.25 to 1 \u03bcg\/ml and those of cefepime were 0.5 to 4 \u03bcg\/ml, and resistance to ceftazidime and piperacillin-tazobactam was generalized. Despite this good activity, the MICs of ertapenem for ESBL-positive klebsiellas mostly were two- to fourfold above those for ESBL-negative strains, and the MICs for AmpC-hyperproducing\n            <jats:italic>Enterobacter cloacae<\/jats:italic>\n            and\n            <jats:italic>Citrobacter freundii<\/jats:italic>\n            mutants exceeded those for the corresponding AmpC-basal mutants. These differentials did not increase when the inoculum was raised from 10\n            <jats:sup>4<\/jats:sup>\n            to 10\n            <jats:sup>6<\/jats:sup>\n            CFU\/spot, contraindicating significant lability. Carbapenemase producers were also tested. The IMP-1 metallo-\u03b2-lactamase conferred substantial ertapenem resistance (MIC, 128 \u03bcg\/ml) in a porin-deficient\n            <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n            strain, whereas a MIC of 6 \u03bcg\/ml was recorded for its porin-expressing revertant. SME-1 carbapenemase was associated with an ertapenem MIC of 2 \u03bcg\/ml for\n            <jats:italic>Serratia marcescens<\/jats:italic>\n            S6, compared with &lt;0.03 \u03bcg\/ml for\n            <jats:italic>Serratia<\/jats:italic>\n            strains lacking this enzyme. In summary, ertapenem had good activity against strains with potent \u03b2-lactamases, except for those with known carbapenemases.\n          <\/jats:p>","DOI":"10.1128\/aac.45.10.2831-2837.2001","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:06:42Z","timestamp":1027764402000},"page":"2831-2837","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":78,"title":["Activity of Ertapenem (MK-0826) versus\n            <i>Enterobacteriaceae<\/i>\n            with Potent \u03b2-Lactamases"],"prefix":"10.1128","volume":"45","author":[{"given":"David M.","family":"Livermore","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Antibiotic Resistance Monitoring and Reference Laboratory, Central Public Health Laboratory, London NW9 5HT, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen J.","family":"Oakton","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Antibiotic Resistance Monitoring and Reference Laboratory, Central Public Health Laboratory, London NW9 5HT, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"Carter","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Antibiotic Resistance Monitoring and Reference Laboratory, Central Public Health Laboratory, London NW9 5HT, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Warner","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Antibiotic Resistance Monitoring and Reference Laboratory, Central Public Health Laboratory, London NW9 5HT, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.2.583-588.2001"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/45.2.183"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.5.1168"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.6.1556-1561.2000"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.3.563"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/33.5.949"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)05954-6"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.1.196-199.2000"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/45.1.1"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.1.88-95.2001"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/40.4.533"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.8.2023-2027.2000"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.34.5.858"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)75604-X"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.5.1170"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.8.4.557"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/39.6.673"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1369-5274(00)00128-4"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/38.3.409"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/40.6.823"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.38.6.1262"},{"key":"e_1_3_2_23_2","unstructured":"National Committee for Clinical Laboratory Standards\n          Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically\n          5th ed. Approved standard M7\u2013A5\n          2000\n          National Committee for Clinical Laboratory Standards\n          Wayne Pa"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.38.1.71"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.2.349"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/24.suppl_A.207"},{"key":"e_1_3_2_27_2","unstructured":"Yuan\n              M.\n          PhD thesis.\n          2000\n          University of London\n          London United Kingdom"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/41.5.527"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.45.10.2831-2837.2001","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.45.10.2831-2837.2001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T16:47:31Z","timestamp":1645462051000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.45.10.2831-2837.2001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,10]]},"references-count":27,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2001,10]]}},"alternative-id":["10.1128\/AAC.45.10.2831-2837.2001"],"URL":"https:\/\/doi.org\/10.1128\/aac.45.10.2831-2837.2001","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,10]]},"assertion":[{"value":"2001-01-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-07-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-10-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}