{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T03:40:57Z","timestamp":1778125257945,"version":"3.51.4"},"reference-count":26,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2001,11,1]],"date-time":"2001-11-01T00:00:00Z","timestamp":1004572800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2001,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Amoxicillin plasma concentrations (\n            <jats:italic>n<\/jats:italic>\n            = 1,152) obtained from 48 healthy subjects in two bioequivalence studies were used to develop limited-sampling strategy (LSS) models for estimating the area under the concentration-time curve (AUC), the maximum concentration of drug in plasma (\n            <jats:italic>C<\/jats:italic>\n            <jats:sub>max<\/jats:sub>\n            ), and the time interval of concentration above MIC susceptibility breakpoints in plasma (T&gt;MIC). Each subject received 500-mg amoxicillin, as reference and test capsules or suspensions, and plasma concentrations were measured by a validated microbiological assay. Linear regression analysis and a \u201cjack-knife\u201d procedure revealed that three-point LSS models accurately estimated (\n            <jats:italic>R<\/jats:italic>\n            <jats:sup>2<\/jats:sup>\n            , 0.92; precision, &lt;5.8%) the AUC from 0 h to infinity (AUC\n            <jats:sub>0-\u221e<\/jats:sub>\n            ) of amoxicillin for the four formulations tested. Validation tests indicated that a three-point LSS model (1, 2, and 5 h) developed for the reference capsule formulation predicts the following accurately (\n            <jats:italic>R<\/jats:italic>\n            <jats:sup>2<\/jats:sup>\n            , 0.94 to 0.99): (i) the individual AUC\n            <jats:sub>0-\u221e<\/jats:sub>\n            for the test capsule formulation in the same subjects, (ii) the individual AUC\n            <jats:sub>0-\u221e<\/jats:sub>\n            for both reference and test suspensions in 24 other subjects, and (iii) the average AUC\n            <jats:sub>0-\u221e<\/jats:sub>\n            following single oral doses (250 to 1,000 mg) of various amoxicillin formulations in 11 previously published studies. A linear regression equation was derived, using the same sampling time points of the LSS model for the AUC\n            <jats:sub>0-\u221e<\/jats:sub>\n            , but using different coefficients and intercept, for estimating\n            <jats:italic>C<\/jats:italic>\n            <jats:sub>max<\/jats:sub>\n            . Bioequivalence assessments based on LSS-derived AUC\n            <jats:sub>0-\u221e<\/jats:sub>\n            's and\n            <jats:italic>C<\/jats:italic>\n            <jats:sub>max<\/jats:sub>\n            's provided results similar to those obtained using the original values for these parameters. Finally, two-point LSS models (\n            <jats:italic>R<\/jats:italic>\n            <jats:sup>2<\/jats:sup>\n            = 0.86 to 0.95) were developed for T&gt;MICs of 0.25 or 2.0 \u03bcg\/ml, which are representative of microorganisms susceptible and resistant to amoxicillin.\n          <\/jats:p>","DOI":"10.1128\/aac.45.11.3029-3036.2001","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:06:42Z","timestamp":1027764402000},"page":"3029-3036","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":17,"title":["Development and Validation of Limited-Sampling Strategies for Predicting Amoxicillin Pharmacokinetic and Pharmacodynamic Parameters"],"prefix":"10.1128","volume":"45","author":[{"given":"Guilherme","family":"Suarez-Kurtz","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Instituto Nacional de Ca\u0302ncer, Coordenac\u0327a\u0303o de Pesquisa,1 and"},{"name":"<!--label omitted: 2-->Unidade de Farmacologia Cl\u0131\u0301nica, Santa Casa da Miserico\u0301rdia,2 Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederico Mota","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Instituto Nacional de Ca\u0302ncer, Coordenac\u0327a\u0303o de Pesquisa,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fla\u0301vio L.","family":"Vicente","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Instituto Nacional de Ca\u0302ncer, Coordenac\u0327a\u0303o de Pesquisa,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio J.","family":"Struchiner","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Instituto Nacional de Ca\u0302ncer, Coordenac\u0327a\u0303o de Pesquisa,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.22.3.353"},{"key":"e_1_3_2_3_2","unstructured":"Ag\u00eancia Nacional de Vigil\u00e2ncia Sanit\u00e1ria\n          Resolu\u00e7\u00e3o 391\/99. Di\u00e1rio Oficial da Uni\u00e3o Bras\u0131\u0301lia\n          1999\n          318\n          330\n          Ag\u00eancia Nacional de Vigil\u00e2ncia Sanit\u00e1ria\n          Bras\u0131\u0301lia Brazil"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.1130070407"},{"key":"e_1_3_2_5_2","unstructured":"EPUC\n          Dicion\u00e1rio de Especialidades Farmac\u00eauticas. Jornal Brasileiro de Medicina\n          1999\n          173\n          174\n          EPUC\n          Sao Paulo Brazil"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/00401706.1974.10489231"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-198800357-00007"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-3659(97)00165-X"},{"key":"e_1_3_2_9_2","unstructured":"Ingram\n              D.\n              Block\n              R.\n          Mathematical methods in medicine part 1. Statistical and analytical techniques.\n          1984\n          John Wiley and Sons\n          Chichester United Kingdom"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002800050397"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1987.135"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-199708000-00009"},{"key":"e_1_3_2_13_2","unstructured":"Mathsoft\n          Splus 4 guide to statistics.\n          1997\n          Mathsoft\n          Seattle Wash"},{"key":"e_1_3_2_14_2","first-page":"428","article-title":"Amoxicillin kinetics and ethanol ingestion.","volume":"26","author":"Morasso M. I.","year":"1988","unstructured":"Morasso M. I. Hip A. M\u00e1rquez M. Gonz\u00e1lez C. Arancibia A. Amoxicillin kinetics and ethanol ingestion. Int. J. Clin. Pharmacol. Ther. Toxicol. 26 1988 428 431","journal-title":"Int. J. Clin. Pharmacol. Ther. 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NCCLS document M100\u2013S11.\n          2001\n          National Committee for Clinical Laboratory Standards\n          Wayne Pa"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.5414\/CPP39167"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/bdd.2510160302"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02333024"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03189784"},{"key":"e_1_3_2_22_2","first-page":"935","article-title":"A limited sampling model for vinblastine pharmacokinetics.","volume":"71","author":"Ratain M. J.","year":"1987","unstructured":"Ratain M. J. Vogelzang N. J. A limited sampling model for vinblastine pharmacokinetics. Cancer Treat. Rep. 71 1987 935 939","journal-title":"Cancer Treat. Rep."},{"key":"e_1_3_2_23_2","first-page":"4127","article-title":"Limited sampling models for amonafine (NSC 308847).","volume":"48","author":"Ratain M. J.","year":"1988","unstructured":"Ratain M. J. Staubus A. E. Schilsky R. L. Mailspeis L. Limited sampling models for amonafine (NSC 308847). Cancer Res. 48 1988 4127 4130","journal-title":"Cancer Res."},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01068419"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002280050688"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.1.134"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/23.6.861"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.45.11.3029-3036.2001","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.45.11.3029-3036.2001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T16:53:37Z","timestamp":1645462417000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.45.11.3029-3036.2001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,11]]},"references-count":26,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2001,11]]}},"alternative-id":["10.1128\/AAC.45.11.3029-3036.2001"],"URL":"https:\/\/doi.org\/10.1128\/aac.45.11.3029-3036.2001","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,11]]},"assertion":[{"value":"2000-12-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-08-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-11-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}