{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:00:26Z","timestamp":1791036026933,"version":"4.1.0"},"reference-count":25,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2001,11,1]],"date-time":"2001-11-01T00:00:00Z","timestamp":1004572800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2001,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            We found that an extract of\n            <jats:italic>Arctostaphylos uva-ursi<\/jats:italic>\n            markedly reduced the MICs of \u03b2-lactam antibiotics, such as oxacillin and cefmetazole, against methicillin-resistant\n            <jats:italic>Staphylococcus aureus<\/jats:italic>\n            . We isolated the effective compound and identified it as corilagin. Corilagin reduced the MICs of various \u03b2-lactams by 100- to 2,000-fold but not the MICs of other antimicrobial agents tested. The effect of corilagin and oxacillin was synergistic. Corilagin showed a bactericidal action when added to the growth medium in combination with oxacillin.\n          <\/jats:p>","DOI":"10.1128\/aac.45.11.3198-3201.2001","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:06:42Z","timestamp":1027764402000},"page":"3198-3201","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":126,"title":["Marked Potentiation of Activity of \u03b2-Lactams against Methicillin-Resistant\n            <i>Staphylococcus aureus<\/i>\n            by Corilagin"],"prefix":"10.1128","volume":"45","author":[{"given":"Masato","family":"Shimizu","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Department of Microbiology1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumiko","family":"Shiota","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Microbiology1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tohru","family":"Mizushima","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Microbiology1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyuki","family":"Ito","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Department of Pharmacognosy,2 Faculty of Pharmaceutical Sciences, Okayama University, Tsushima, Okayama, 700-8530, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Hatano","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Department of Pharmacognosy,2 Faculty of Pharmaceutical Sciences, Okayama University, Tsushima, Okayama, 700-8530, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Yoshida","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Department of Pharmacognosy,2 Faculty of Pharmaceutical Sciences, Okayama University, Tsushima, Okayama, 700-8530, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomofusa","family":"Tsuchiya","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Microbiology1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1099-1573(200008)14:5<371::AID-PTR625>3.0.CO;2-F"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00261186"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.27.4.632"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1139\/y95-198"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.50.283"},{"key":"e_1_3_2_7_2","unstructured":"Eliopoulos\n              G. 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