{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T21:09:46Z","timestamp":1694984986816},"reference-count":24,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2001,12,1]],"date-time":"2001-12-01T00:00:00Z","timestamp":1007164800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2001,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Triple therapy consisting of clarithromycin (CLR), lansoprazole (LPZ), and amoxicillin (AMZ) is effective as eradication therapy for patients with peptic ulcer disease and\n            <jats:italic>Helicobacter pylori<\/jats:italic>\n            infection. We evaluated the effects of LPZ and AMZ on the uptake of [\n            <jats:sup>14<\/jats:sup>\n            C]CLR into the gastric tissue of rats. After administration of [\n            <jats:sup>14<\/jats:sup>\n            C]CLR alone or in combination with LPZ and AMZ, the distributions of [\n            <jats:sup>14<\/jats:sup>\n            C]CLR in the main organs and gastrointestinal tissues were compared. LPZ and AMZ had no effect on the distribution of [\n            <jats:sup>14<\/jats:sup>\n            C]CLR in any tissue except gastric tissue. The concentration of radioactivity in gastric tissue was several times higher when [\n            <jats:sup>14<\/jats:sup>\n            C]CLR was administered orally together with LPZ than when it was administered alone. The gastric emptying of [\n            <jats:sup>14<\/jats:sup>\n            C]CLR became smaller in the case of the coadministration of LPZ. AMZ had no apparent influence on the disposition of [\n            <jats:sup>14<\/jats:sup>\n            C]CLR. After the intravenous administration of [\n            <jats:sup>14<\/jats:sup>\n            C]CLR, no effects of drug coadministration were evident. In vitro uptake of [\n            <jats:sup>14<\/jats:sup>\n            C]CLR into gastric tissue was enhanced in the case of a high-pH environment. The uptake was not influenced by the concurrent presence of LPZ and AMZ. These results suggest that the penetration of [\n            <jats:sup>14<\/jats:sup>\n            C]CLR possibly depends on elevated gastric pH, as gastric acid secretion was inhibited by LPZ, and this may be a primary factor in explaining why the concentration of [\n            <jats:sup>14<\/jats:sup>\n            C]CLR at the target site, gastric tissue, was enhanced by the coadministration of LPZ.\n          <\/jats:p>","DOI":"10.1128\/aac.45.12.3451-3455.2001","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:06:42Z","timestamp":1027764402000},"page":"3451-3455","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":4,"title":["Effects of Lansoprazole and Amoxicillin on Uptake of [\n            <sup>14<\/sup>\n            C]Clarithromycin into Gastric Tissue in Rats"],"prefix":"10.1128","volume":"45","author":[{"given":"Hiromi","family":"Endo","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Department of Drug Metabolism, Research Center, Taisho Pharmaceutical Co., Ltd., 403, Saitama-shi, Saitama 330-8530, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo","family":"Yoshida","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Drug Metabolism, Research Center, Taisho Pharmaceutical Co., Ltd., 403, Saitama-shi, Saitama 330-8530, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Ohmi","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Drug Metabolism, Research Center, Taisho Pharmaceutical Co., Ltd., 403, Saitama-shi, Saitama 330-8530, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shohei","family":"Higuchi","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Drug Metabolism, Research Center, Taisho Pharmaceutical Co., Ltd., 403, Saitama-shi, Saitama 330-8530, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/34.6.1025"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.158.15.1651"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.1996.tb00183.x"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/22.5.631"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.1992.tb00051.x"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365528809091718"},{"key":"e_1_3_1_8_2","first-page":"44","article-title":"Amoxicillin for the treatment of Helicobacter pylori infection.","volume":"31","author":"Hirschl A. M.","year":"1996","unstructured":"Hirschl A. M. Rotter M. L. Amoxicillin for the treatment of Helicobacter pylori infection. J. Gastroenterol. 31 1996 44 47","journal-title":"J. Gastroenterol."},{"key":"e_1_3_1_9_2","first-page":"1241","article-title":"Acid-peptic disorders","volume":"1","author":"Isenberg J. I.","year":"1991","unstructured":"Isenberg J. I. Mcquaid K. R. Laine L. Rubin W. Acid-peptic disorders Textbook of gastroenterology Yamada T. Alpers D. H. Owyang C. Powell D. W. Silverstein F. E. 1 1991 1241 1339 J. B. Lippincott Company Philadelphia, Pa","journal-title":"Textbook of gastroenterology"},{"key":"e_1_3_1_10_2","first-page":"3907","article-title":"General pharmacological studies on AG-1749 Jpn.","volume":"18","author":"Kito G.","year":"1990","unstructured":"Kito G. Yoshimura H. Sato H. Inatomi N. Inada I. General pharmacological studies on AG-1749 Jpn. Pharmacol. Ther. 18 1990 3907 3925","journal-title":"Pharmacol. Ther."},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.33.5.751"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1998.00280.x"},{"key":"e_1_3_1_13_2","first-page":"1","article-title":"Campylobacter pylori in health and disease: an ecological perspective.","volume":"1","author":"Lee A.","year":"1988","unstructured":"Lee A. Hazell S. L. Campylobacter pylori in health and disease: an ecological perspective. Microb. Ecol. Health Dis. 1 1988 1 16","journal-title":"Microb. Ecol. Health Dis."},{"key":"e_1_3_1_14_2","first-page":"1273","article-title":"Unidentified curved bacilli on gastric epithelium in active chronic gastritis.","author":"Marshall B.","year":"1983","unstructured":"Marshall B. Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet ii 1983 1273 1275","journal-title":"Lancet"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-5198(19)39913-5"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.40.725"},{"key":"e_1_3_1_17_2","first-page":"64","article-title":"Effects of H2-receptor antagonists upon physiological acid secretory states in animals.","volume":"233","author":"Pendleton R. G.","year":"1985","unstructured":"Pendleton R. G. Cook P. G. Shepherd-Rose A. Mangel A. W. Effects of H2-receptor antagonists upon physiological acid secretory states in animals. J. Pharmacol. Exp. Ther. 233 1985 64 69","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199104113241507"},{"key":"e_1_3_1_19_2","first-page":"1860","article-title":"Clarithromycin as monotherapy for eradication of Helicobacter pylori: a randomized, double-blind trial.","volume":"88","author":"Peterson W. L.","year":"1993","unstructured":"Peterson W. L. Graham D. Y. Marshall B. Blaser M. J. Genta R. M. Klein P. D. Stratton C. W. Drnec J. Prokocimer P. Siepman N. Clarithromycin as monotherapy for eradication of Helicobacter pylori: a randomized, double-blind trial. Am. J. Gastroenterol. 88 1993 1860 1864","journal-title":"Am. J. Gastroenterol."},{"key":"e_1_3_1_20_2","first-page":"806","article-title":"Antisecretory and antiulcer activities of a novel proton pump inhibitor AG-1749 in dogs and rats.","volume":"248","author":"Satoh H.","year":"1989","unstructured":"Satoh H. Inatomi N. Nagaya H. Inada I. Nohara A. Nakamura N. Maki Y. Antisecretory and antiulcer activities of a novel proton pump inhibitor AG-1749 in dogs and rats. J. Pharmacol. Exp. Ther. 248 1989 806 815","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1998.169_b.x"},{"key":"e_1_3_1_22_2","first-page":"933","article-title":"Metabolic fate of TE-031 (A-56268) (IX) absorption and excretion in humans (HPLC method).","volume":"36","author":"Suwa T.","year":"1988","unstructured":"Suwa T. Ohtake T. Urano H. Kodama T. Nakamura M. Iwatate C. Watanabe T. Metabolic fate of TE-031 (A-56268) (IX) absorption and excretion in humans (HPLC method). Chemotherapy (Tokyo) 36 1988 933 940","journal-title":"Chemotherapy (Tokyo)"},{"key":"e_1_3_1_23_2","first-page":"227","article-title":"Metabolic fate of TE-031 (A-56268) (IV) metabolism of 14C-TE-031 in rats and dogs.","volume":"36","author":"Suwa T.","year":"1988","unstructured":"Suwa T. Yoshida H. Yoshitomi S. Kamei K. Metabolic fate of TE-031 (A-56268) (IV) metabolism of 14C-TE-031 in rats and dogs. Chemotherapy (Tokyo) 36 1988 227 237","journal-title":"Chemotherapy (Tokyo)"},{"key":"e_1_3_1_24_2","first-page":"S63","article-title":"Dual therapy with lansoprazole and clarithromycin for eradication of Helicobacter pylori.","volume":"7","author":"Takimoto T.","year":"1995","unstructured":"Takimoto T. Kimura K. Taniguchi Y. Satoh K. Saifuku K. Kihira K. Yoshida Y. Ido K. Dual therapy with lansoprazole and clarithromycin for eradication of Helicobacter pylori. Eur. J. Gastroenterol. Hepatol. 7 1995 S63 S66","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"e_1_3_1_25_2","first-page":"1273","article-title":"Unidentified curved bacilli on gastric epithelium in active chronic gastritis.","author":"Warren J. R.","year":"1983","unstructured":"Warren J. R. Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet ii 1983 1273","journal-title":"Lancet"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.45.12.3451-3455.2001","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.45.12.3451-3455.2001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T17:00:52Z","timestamp":1645462852000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.45.12.3451-3455.2001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,12]]},"references-count":24,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2001,12]]}},"alternative-id":["10.1128\/AAC.45.12.3451-3455.2001"],"URL":"https:\/\/doi.org\/10.1128\/aac.45.12.3451-3455.2001","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,12]]},"assertion":[{"value":"2000-03-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-09-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-12-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}