{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:53:59Z","timestamp":1791140039642,"version":"4.1.0"},"reference-count":42,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2001,2,1]],"date-time":"2001-02-01T00:00:00Z","timestamp":980985600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2001,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Increased production of penicillin-binding protein PBP 4 is known to increase peptidoglycan cross-linking and contributes to methicillin resistance in\n            <jats:italic>Staphylococcus aureus<\/jats:italic>\n            . The\n            <jats:italic>pbp4<\/jats:italic>\n            gene shares a 400-nucleotide intercistronic region with the divergently transcribed\n            <jats:italic>abcA<\/jats:italic>\n            gene, encoding an ATP-binding cassette transporter of unknown function. Our study revealed that methicillin stimulated\n            <jats:italic>abcA<\/jats:italic>\n            transcription but had no effects on\n            <jats:italic>pbp4<\/jats:italic>\n            transcription. Analysis of\n            <jats:italic>abcA<\/jats:italic>\n            expression in mutants defective for global regulators showed that\n            <jats:italic>abcA<\/jats:italic>\n            is under the control of\n            <jats:italic>agr<\/jats:italic>\n            . Insertional inactivation of\n            <jats:italic>abcA<\/jats:italic>\n            by an erythromycin resistance determinant did not influence\n            <jats:italic>pbp4<\/jats:italic>\n            transcription, nor did it alter resistance to methicillin and other cell wall-directed antibiotics. However,\n            <jats:italic>abcA<\/jats:italic>\n            mutants showed spontaneous partial lysis on plates containing subinhibitory concentrations of methicillin due to increased spontaneous autolysis. Since the autolytic zymograms of cell extracts were identical in mutants and parental strains, we postulate an indirect role of AbcA in control of autolytic activities and in protection of the cells against methicillin.\n          <\/jats:p>","DOI":"10.1128\/aac.45.2.407-412.2001","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:06:42Z","timestamp":1027764402000},"page":"407-412","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":27,"title":["The AbcA Transporter of\n            <i>Staphylococcus aureus<\/i>\n            Affects Cell Autolysis"],"prefix":"10.1128","volume":"45","author":[{"given":"Gesine","family":"Schrader-Fischer","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Department of Medical Microbiology, University of Zu\u0308rich, CH-8028 Zu\u0308rich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Berger-Ba\u0308chi","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Medical Microbiology, University of Zu\u0308rich, CH-8028 Zu\u0308rich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/j.1574-6968.1983.tb00137.x","article-title":"A novel site on the chromosome of Staphylococcus aureus influencing the level of methicillin resistance: genetic mapping.","volume":"20","author":"Berger-B\u00e4chi B.","year":"1983","unstructured":"Berger-B\u00e4chi B. 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