{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T20:01:21Z","timestamp":1774123281565,"version":"3.50.1"},"reference-count":14,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2001,2,1]],"date-time":"2001-02-01T00:00:00Z","timestamp":980985600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2001,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>We evaluated the efficacy of voriconazole, a new broad-spectrum triazole antifungal compound, in the treatment of murine pulmonary blastomycosis. Since mice metabolize voriconazole rapidly, we took advantage of our previous observation that administration of grapefruit juice to mice resulted in suitable serum voriconazole concentrations so that treatment studies with mice could be done (A. M. Sugar and X.-P. Liu, Med. Mycol. 38:209\u2013121, 2000). Our results show that voriconazole prolonged survival in a dose-dependent fashion and that the fungal burden in the lungs was decreased by voriconazole administered at 40 mg\/kg of body weight\/day. Voriconazole should be studied in humans with blastomycosis.<\/jats:p>","DOI":"10.1128\/aac.45.2.601-604.2001","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:06:42Z","timestamp":1027764402000},"page":"601-604","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":58,"title":["Efficacy of Voriconazole in Treatment of Murine Pulmonary Blastomycosis"],"prefix":"10.1128","volume":"45","author":[{"given":"Alan M.","family":"Sugar","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Evans Memorial Department of Clinical Research and Department of Medicine, Boston Medical Center, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiu-Ping","family":"Liu","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Evans Memorial Department of Clinical Research and Department of Medicine, Boston Medical Center, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1439-0507.1989.tb02300.x","article-title":"Efficacy of itraconazole in blastomycosis in a murine model and comparison with ketoconazole.","volume":"32","author":"Arathoon E. 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Respir. Infect. 12 1997 263 267","journal-title":"Semin. Respir. Infect."},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"L135","DOI":"10.1016\/S0024-3205(98)00013-7","article-title":"Mechanism-based inactivation of human cytochrome P450 3A4 by grapefruit juice and red wine.","volume":"62","author":"Chan W. K.","year":"1998","unstructured":"Chan W. K. Nguyen L. T. Miller V. P. Harris R. Z. Mechanism-based inactivation of human cytochrome P450 3A4 by grapefruit juice and red wine. Life Sci. 62 1998 L135 L142","journal-title":"Life Sci."},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1093\/jac\/42.4.531","article-title":"Comparison of the in-vitro activity of voriconazole (UK-109, 496), itraconazole and amphotericin B against clinical isolates of Aspergillus fumigatus.","volume":"42","author":"Cuenca-Estrella M.","year":"1998","unstructured":"Cuenca-Estrella M. Rodriguez-Tudela J. L. Mellado E. Martinez-Suarez J. V. Monzon A. 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Document M27-P.\n          1992\n          National Committee for Clinical Laboratory Standards\n          Wayne Pa"},{"key":"e_1_3_2_13_2","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1097\/00007691-199906000-00009","article-title":"Grapefruit juice decreases the systemic availability of itraconazole capsules in healthy volunteers.","volume":"21","author":"Penzak S. R.","year":"1999","unstructured":"Penzak S. R. Gubbins P. O. Gurley B. J. Wang P. L. Saccente M. Grapefruit juice decreases the systemic availability of itraconazole capsules in healthy volunteers. Ther. Drug Monit. 21 1999 304 309","journal-title":"Ther. Drug Monit."},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.4.996"},{"key":"e_1_3_2_15_2","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1080\/mmy.38.3.209.212","article-title":"Effect of grapefruit juice on serum voriconazle concentrations in the mouse.","volume":"38","author":"Sugar A. 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