{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:50:33Z","timestamp":1770339033990,"version":"3.49.0"},"reference-count":8,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2001,4,1]],"date-time":"2001-04-01T00:00:00Z","timestamp":986083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2001,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n            antigen 85 is induced in vitro by isoniazid (INH); its sustained induction in sputum during tuberculosis (TB) therapy predicts relapse. In this trial, rifampin or rifalazil inhibited the induction of sputum antigen 85 by INH in a dose-dependent fashion. This approach may facilitate the evaluation of new TB drugs.\n          <\/jats:p>","DOI":"10.1128\/aac.45.4.1302-1304.2001","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:56:57Z","timestamp":1027763817000},"page":"1302-1304","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":25,"title":["Inhibition of Isoniazid-Induced Expression of\n            <i>Mycobacterium tuberculosis<\/i>\n            Antigen 85 in Sputum: Potential Surrogate Marker in Tuberculosis Chemotherapy Trials"],"prefix":"10.1128","volume":"45","author":[{"given":"Robert S.","family":"Wallis","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->University of Medicine and Dentistry\u2014New Jersey Medical School, Newark, New Jersey1;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manijeh","family":"Phillips","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Case Western Reserve University, Cleveland, Ohio2;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John L.","family":"Johnson","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Case Western Reserve University, Cleveland, Ohio2;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucile\u0301ia","family":"Teixeira","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Universidade Federal do Esp\u0131\u0301rito Santo, Vito\u0301ria, Brazil3;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lia Ma\u0301rcia Massini Canedo","family":"Rocha","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Universidade Federal do Esp\u0131\u0301rito Santo, Vito\u0301ria, Brazil3;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ethel","family":"Maciel","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Universidade Federal do Esp\u0131\u0301rito Santo, Vito\u0301ria, Brazil3;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynn","family":"Rose","sequence":"additional","affiliation":[{"name":"<!--label omitted: 4-->PathoGenesis Corporation, Seattle Washington4"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Wells","sequence":"additional","affiliation":[{"name":"<!--label omitted: 4-->PathoGenesis Corporation, Seattle Washington4"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moise\u0301s","family":"Palaci","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Universidade Federal do Esp\u0131\u0301rito Santo, Vito\u0301ria, Brazil3;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reynaldo","family":"Dietze","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Universidade Federal do Esp\u0131\u0301rito Santo, Vito\u0301ria, Brazil3;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen","family":"Eisenach","sequence":"additional","affiliation":[{"name":"<!--label omitted: 5-->University of Arkansas for Medical Sciences, Little Rock, Arkansas5; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerrold J.","family":"Ellner","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->University of Medicine and Dentistry\u2014New Jersey Medical School, Newark, New Jersey1;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"155","article-title":"Early bactericidal activity of ethambutol, pyrazinamide and the fixed combination of isoniazid, rifampicin and pyrazinamide (Rifater) in patients with pulmonary tuberculosis.","volume":"86","author":"Botha F. J.","year":"1996","unstructured":"Botha F. J. Sirgel F. A. Parkin D. P. Van de Wal B. W. Donald P. R. Mitchison D. A. Early bactericidal activity of ethambutol, pyrazinamide and the fixed combination of isoniazid, rifampicin and pyrazinamide (Rifater) in patients with pulmonary tuberculosis. S. Afr. Med. J. 86 1996 155 158","journal-title":"S. Afr. Med. J."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.156.3.9609132"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.7.1754"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-3879(85)90040-6"},{"key":"e_1_3_2_6_2","first-page":"423","article-title":"Influence of initial drug resistance on the response to short-course chemotherapy of pulmonary tuberculosis.","volume":"133","author":"Mitchison D. A.","year":"1986","unstructured":"Mitchison D. A. Nunn A. J. Influence of initial drug resistance on the response to short-course chemotherapy of pulmonary tuberculosis. Am. Rev. Respir. Dis. 133 1986 423 430","journal-title":"Am. Rev. Respir. Dis."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/32.6.867"},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1086\/515701","article-title":"Induction of the antigen 85 complex of M. tuberculosis in sputum: a determinant of outcome in pulmonary tuberculosis.","volume":"178","author":"Wallis R. S.","year":"1998","unstructured":"Wallis R. S. Perkins M. Phillips M. Joloba M. Demchuk B. Namale A. Johnson J. L. Williams D. Wolski K. Teixeira L. Dietze R. Mugerwa R. D. Eisenach K. D. Ellner J. J. Induction of the antigen 85 complex of M. tuberculosis in sputum: a determinant of outcome in pulmonary tuberculosis. J. Infect. Dis. 178 1998 1115 1121","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1164\/ajrccm.161.4.9903087","article-title":"Predicting the outcome of therapy for pulmonary tuberculosis.","volume":"161","author":"Wallis R. S.","year":"2000","unstructured":"Wallis R. S. Perkins M. Phillips M. Joloba M. Namale A. Whalen C. C. Johnson J. L. Teixeira L. Dietze R. Mugerwa R. D. Eisenach K. D. Ellner J. J. Predicting the outcome of therapy for pulmonary tuberculosis. Am. J. Respir. Crit. Care Med. 161 2000 1076 1080","journal-title":"Am. J. Respir. Crit. Care Med."}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.45.4.1302-1304.2001","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.45.4.1302-1304.2001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T17:18:24Z","timestamp":1645463904000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.45.4.1302-1304.2001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,4]]},"references-count":8,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2001,4]]}},"alternative-id":["10.1128\/AAC.45.4.1302-1304.2001"],"URL":"https:\/\/doi.org\/10.1128\/aac.45.4.1302-1304.2001","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,4]]},"assertion":[{"value":"2000-07-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-12-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-04-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}