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In a bioassay-guided chemical fractionation, the leishmanicidal activity in CLF completely and irreversibly inhibited promastigote growth. This fraction was also active against amastigotes in infected murine macrophages. Chemical analysis of CLF identified an iboga-type indole alkaloid coronaridine as one of its major compounds. Coronaridine showed potent antileishmanial activity, inhibiting promastigote and amastigote growth. Promastigotes and amastigotes treated with CLF or coronaridine showed pronounced alterations in their mitochondria as assessed by transmission electron microscopy.<\/jats:p>","DOI":"10.1128\/aac.45.5.1349-1354.2001","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:55:30Z","timestamp":1027763730000},"page":"1349-1354","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":142,"title":["Antileishmanial Activity of an Indole Alkaloid from<i>Peschiera australis<\/i>"],"prefix":"10.1128","volume":"45","author":[{"given":"Jan Carlo","family":"Delorenzi","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Laborato\u0301rio de Imunobiologia das Leishmanioses, Departamento de Imunologia-Instituto de Microbiologia,1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u0301rcia","family":"Attias","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Laborato\u0301rio de Ultraestrutura Celular Hertha Meyer, Instituto de Biof\u0131\u0301sica Carlos Chagas Filho,2 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cerli R.","family":"Gattass","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Laborato\u0301rio de Ultraestrutura Celular Hertha Meyer, Instituto de Biof\u0131\u0301sica Carlos Chagas Filho,2 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo","family":"Andrade","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Departamento Qu\u0131\u0301mica Orga\u0302nica-Instituto de Qu\u0131\u0301mica-Universidade Federal do Rio de Janeiro,3 Rio de Janeiro, RJ;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cla\u0301udia","family":"Rezende","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Departamento Qu\u0131\u0301mica Orga\u0302nica-Instituto de Qu\u0131\u0301mica-Universidade Federal do Rio de Janeiro,3 Rio de Janeiro, RJ;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A\u0302ngelo","family":"da Cunha Pinto","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Departamento Qu\u0131\u0301mica Orga\u0302nica-Instituto de Qu\u0131\u0301mica-Universidade Federal do Rio de Janeiro,3 Rio de Janeiro, RJ;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ame\u0301lia T.","family":"Henriques","sequence":"additional","affiliation":[{"name":"<!--label omitted: 4-->Faculdade de Farma\u0301cia-Universidade Federal do Rio Grande do Sul, Porto Alegre, RS4; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dumith C.","family":"Bou-Habib","sequence":"additional","affiliation":[{"name":"<!--label omitted: 5-->Centro de Pesquisas Gonc\u0327alo Moniz, Fundac\u0327a\u0303o Oswaldo Cruz, Salvador BA,5Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elvira M. 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