{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T17:00:00Z","timestamp":1758992400806},"reference-count":14,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2001,6,1]],"date-time":"2001-06-01T00:00:00Z","timestamp":991353600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2001,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            We compared the oral antibacterial activities of telithromycin (HMR 3647), a new ketolide drug, in different infections induced in mice by\n            <jats:italic>Staphylococcus aureus, Streptococcus pneumoniae<\/jats:italic>\n            , streptococci, enterococci, and\n            <jats:italic>Haemophilus influenzae<\/jats:italic>\n            with those of various macrolides and pristinamycin. Unlike all other comparators, telithromycin displayed a high therapeutic activity, particularly in septicemia induced by erythromycin A-resistant pathogens, where the ketolide was the only active compound, displaying effective doses between 3 and 26 mg\/kg of body weight. Against\n            <jats:italic>H. influenzae,<\/jats:italic>\n            telithromycin was the most effective compound. Telithromycin displayed bacteriostatic behavior against\n            <jats:italic>S. pneumoniae<\/jats:italic>\n            and\n            <jats:italic>H. influenzae<\/jats:italic>\n            . The ketolide was also active against thigh muscle infection induced by\n            <jats:italic>S. aureus<\/jats:italic>\n            . The pharmacokinetic properties of telithromycin accounted for its outstanding well-balanced oral in vivo efficacy against both gram-positive cocci, whatever their phenotype of resistance, and\n            <jats:italic>H. influenzae<\/jats:italic>\n            .\n          <\/jats:p>","DOI":"10.1128\/aac.45.6.1688-1692.2001","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:06:42Z","timestamp":1027764402000},"page":"1688-1692","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":19,"title":["In Vivo Efficacy of the New Ketolide Telithromycin (HMR 3647) in Murine Infection Models"],"prefix":"10.1128","volume":"45","author":[{"given":"Alain","family":"Bonnefoy","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Infectious Diseases Group, Microbiology, Aventis Pharma-Hoechst Marion Roussel, 93235 Romainville Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Guitton","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Infectious Diseases Group, Microbiology, Aventis Pharma-Hoechst Marion Roussel, 93235 Romainville Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carole","family":"Delachaume","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Infectious Diseases Group, Microbiology, Aventis Pharma-Hoechst Marion Roussel, 93235 Romainville Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Le Priol","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Infectious Diseases Group, Microbiology, Aventis Pharma-Hoechst Marion Roussel, 93235 Romainville Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Marie","family":"Girard","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Infectious Diseases Group, Microbiology, Aventis Pharma-Hoechst Marion Roussel, 93235 Romainville Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","unstructured":"Barry\n              A.\n          Procedures and theoretical considerations for testing antimicrobial agents in agar media\n          Antibiotics in laboratory medicine.\n              Lorian\n              V.\n          1991\n          1\n          16\n          The Williams & Wilkins Co.\n          Baltimore Md"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.8.2138"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0732-8893(98)00022-4"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/42.6.703"},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/jac\/41.2.149","article-title":"Pharmacodynamic properties of HMR 3647, a novel ketolide, on respiratory pathogens, enterococci and Bacteroides fragilis demonstrated by studies of time-kill kinetics and postantibiotic effect.","volume":"41","author":"Boswell F. J.","year":"1998","unstructured":"Boswell F. J. Andrews J. M. Wise R. Pharmacodynamic properties of HMR 3647, a novel ketolide, on respiratory pathogens, enterococci and Bacteroides fragilis demonstrated by studies of time-kill kinetics and postantibiotic effect. J. Antimicrob. Chemother. 41 1998 149 153","journal-title":"J. Antimicrob. Chemother."},{"key":"e_1_3_2_7_2","unstructured":"Cleeland\n              R.\n              Squires\n              E.\n          Evaluation of new antimicrobials in vitro and in experimental animal infections\n          Antibiotics in laboratory medicine.\n              Lorian\n              V.\n          1991\n          739\n          786\n          The Williams & Wilkins Co.\n          Baltimore Md"},{"key":"e_1_3_2_8_2","first-page":"1609","article-title":"Antibacterial activity of rokitamycin against fresh clinical isolates.","volume":"45","author":"Deguchi K.","year":"1992","unstructured":"Deguchi K. Yokota N. Koguchi M. Suzuki Y. Fukayama S. Ishihara R. Oda S. Antibacterial activity of rokitamycin against fresh clinical isolates. Jpn. J. Antibiot. 45 1992 1609 1621","journal-title":"Jpn. J. Antibiot."},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1086\/514953"},{"key":"e_1_3_2_10_2","first-page":"99","article-title":"A simplified method of evaluating dose-effect experiments.","volume":"96","author":"Litchfield J. T.","year":"1949","unstructured":"Litchfield J. T. Wilcoxon F. A simplified method of evaluating dose-effect experiments. J. Pharmacol. Exp. Ther. 96 1949 99 113","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.10.2510"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.11.3032"},{"key":"e_1_3_2_13_2","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1093\/jac\/45.3.401","article-title":"Pneumococcal macrolide resistance\u2014not a myth.","volume":"45","author":"Perez-Trallero E.","year":"2000","unstructured":"Perez-Trallero E. Pneumococcal macrolide resistance\u2014not a myth. J. Antimicrob. Chemother. 45 2000 401 402","journal-title":"J. Antimicrob. Chemother."},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.3.708"},{"key":"e_1_3_2_15_2","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1093\/jac\/44.4.445","article-title":"In vitro activity of HMR 3647 against Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis and beta-haemolytic streptococci.","volume":"44","author":"Wootton M.","year":"1999","unstructured":"Wootton M. Bowker K. E. Janowska A. Holt H. A. MacGowan A. P. In vitro activity of HMR 3647 against Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis and beta-haemolytic streptococci. J. Antimicrob. Chemother. 44 1999 445 453","journal-title":"J. Antimicrob. Chemother."}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.45.6.1688-1692.2001","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.45.6.1688-1692.2001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T17:05:05Z","timestamp":1645463105000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.45.6.1688-1692.2001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,6]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2001,6]]}},"alternative-id":["10.1128\/AAC.45.6.1688-1692.2001"],"URL":"https:\/\/doi.org\/10.1128\/aac.45.6.1688-1692.2001","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,6]]},"assertion":[{"value":"2000-08-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-03-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-06-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}