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Only tetracyclines, macrolides, quinolones, and rifampin demonstrated in vitro activity against\n            <jats:italic>P. falciparum<\/jats:italic>\n            , which increased after a prolonged exposure (96 or 144 h). In the presence of iron (FeCl\n            <jats:sub>3<\/jats:sub>\n            ), only the activities of tetracyclines and norfloxacin were decreased. Their in vitro activity against intraerythrocytic stages of multidrug-resistant\n            <jats:italic>P. falciparum<\/jats:italic>\n            and their efficacy in vivo favor the use of antibiotics as antimalarial drugs. However, due to their slow antimalarial action and to the fact that they act better after prolonged contact, they probably need to be administered in conjunction with a rapidly acting antimalarial drug, such as a short course of chloroquine or quinine.\n          <\/jats:p>","DOI":"10.1128\/aac.45.6.1746-1750.2001","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:56:57Z","timestamp":1027763817000},"page":"1746-1750","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":95,"title":["In Vitro Activities of Antibiotics against\n            <i>Plasmodium falciparum<\/i>\n            Are Inhibited by Iron"],"prefix":"10.1128","volume":"45","author":[{"given":"Bruno","family":"Pradines","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Unite\u0301 de Parasitologie, Institut de Me\u0301decine Tropicale du Service de Sante\u0301 des Arme\u0301es, Le Pharo, 13998 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Rogier","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Unite\u0301 de Parasitologie, Institut de Me\u0301decine Tropicale du Service de Sante\u0301 des Arme\u0301es, Le Pharo, 13998 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Fusai","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Unite\u0301 de Parasitologie, Institut de Me\u0301decine Tropicale du Service de Sante\u0301 des Arme\u0301es, Le Pharo, 13998 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Mosnier","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Unite\u0301 de Parasitologie, Institut de Me\u0301decine Tropicale du Service de Sante\u0301 des Arme\u0301es, Le Pharo, 13998 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Daries","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Unite\u0301 de Parasitologie, Institut de Me\u0301decine Tropicale du Service de Sante\u0301 des Arme\u0301es, Le Pharo, 13998 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Barret","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Unite\u0301 de Parasitologie, Institut de Me\u0301decine Tropicale du Service de Sante\u0301 des Arme\u0301es, Le Pharo, 13998 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Parzy","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Unite\u0301 de Parasitologie, Institut de Me\u0301decine Tropicale du Service de Sante\u0301 des Arme\u0301es, Le Pharo, 13998 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1995.52.159"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"593","DOI":"10.4269\/ajtmh.1991.45.593","article-title":"Specific ultrastructural effects of desferrioxamine on Plasmodium falciparum in vitro.","volume":"45","author":"Atkinson C. 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