{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T21:35:19Z","timestamp":1770500119239,"version":"3.49.0"},"reference-count":18,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2001,6,1]],"date-time":"2001-06-01T00:00:00Z","timestamp":991353600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2001,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Caspofungin (Merck Pharmaceuticals) was tested in vitro against 25 clinical isolates of\n            <jats:italic>Coccidoides immitis.<\/jats:italic>\n            In vitro susceptibility testing was performed in accordance with the National Committee for Clinical Laboratory Standards document M38-P guidelines. Two\n            <jats:italic>C. immitis<\/jats:italic>\n            isolates for which the caspofungin MICs were different were selected for determination of the minimum effective concentration (MEC), and these same strains were used for animal studies. Survival and tissue burdens of the spleens, livers, and lungs were used as antifungal response markers. Mice infected with strain 98-449 (48-h MIC, 8 \u03bcg\/ml; 48-h MEC, 0.125 \u03bcg\/ml) showed 100% survival to day 50 when treated with caspofungin at \u22651 mg\/kg. Mice infected with strain 98-571 (48-h MIC, 64 \u03bcg\/ml; 48-h MEC, 0.125 \u03bcg\/ml) displayed \u226580% survival when the treatment was caspofungin at \u22655 mg\/kg. Treatment with caspofungin at 0.5, 1, 5, or 10 mg\/kg was effective in reducing the tissue fungal burdens of mice infected with either isolate. When tissue fungal burden study results were compared between strains, caspofungin showed no statistically significant difference in efficacy in the organs of the mice treated with both strains. A better in vitro-in vivo correlation was noted when we used the MEC instead of the MIC as the endpoint for antifungal susceptibility testing. Caspofungin may have a role in the treatment of coccidioidomycosis.\n          <\/jats:p>","DOI":"10.1128\/aac.45.6.1854-1859.2001","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:56:57Z","timestamp":1027763817000},"page":"1854-1859","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":64,"title":["Correlation between Antifungal Susceptibilities of\n            <i>Coccidioides immitis<\/i>\n            In Vitro and Antifungal Treatment with Caspofungin in a Mouse Model"],"prefix":"10.1128","volume":"45","author":[{"given":"Gloria M.","family":"Gonza\u0301lez","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Department of Medicine, Division of Infectious Diseases, The University of Texas Health Science Center at San Antonio,1 and"},{"name":"<!--label omitted: 2-->Departamento de Microbiolog\u0131\u0301a, Facultad de Medicina, Universidad Auto\u0301noma de Nuevo Leo\u0301n, Monterrey, Nuevo Leo\u0301n, Me\u0301xico2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolando","family":"Tijerina","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Departamento de Microbiolog\u0131\u0301a, Facultad de Medicina, Universidad Auto\u0301noma de Nuevo Leo\u0301n, Monterrey, Nuevo Leo\u0301n, Me\u0301xico2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura K.","family":"Najvar","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Medicine, Division of Infectious Diseases, The University of Texas Health Science Center at San Antonio,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosie","family":"Bocanegra","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Medicine, Division of Infectious Diseases, The University of Texas Health Science Center at San Antonio,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Luther","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Medicine, Division of Infectious Diseases, The University of Texas Health Science Center at San Antonio,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael G.","family":"Rinaldi","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Medicine, Division of Infectious Diseases, The University of Texas Health Science Center at San Antonio,1 and"},{"name":"<!--label omitted: 3-->Audie L. Murphy Division, South Texas Veterans Health Care System,3 San Antonio, Texas 78229-3900, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Graybill","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Medicine, Division of Infectious Diseases, The University of Texas Health Science Center at San Antonio,1 and"},{"name":"<!--label omitted: 3-->Audie L. Murphy Division, South Texas Veterans Health Care System,3 San Antonio, Texas 78229-3900, and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.11.2333"},{"key":"e_1_3_1_3_2","unstructured":"Current\n              W. L.\n              Tang\n              J.\n              Boylan\n              C.\n              Watson\n              P.\n              Zeckner\n              D.\n              Turner\n              W.\n              Rodriguez\n              M.\n              Dixon\n              C.\n              Ma\n              D.\n              Radding\n              J. A.\n          Glucan biosynthesis as a target for antifungals: the echinocandin class of antifungal agents\n          Antifungal agents\n          1st ed.\n              Dixon\n              G. K.\n              Copping\n              L. G.\n              Hollomon\n              D. W.\n          1995\n          143\n          157\n          Bios Scientific Publishers\n          Oxford United Kingdom"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.8.1835"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.1.1"},{"key":"e_1_3_1_6_2","first-page":"603","article-title":"Ketoconazole therapy of progressive coccidioidomycosis. Comparisons of 400- and 800-mg doses and observations at higher doses.","volume":"84","author":"Galgiani J. N.","year":"1988","unstructured":"Galgiani J. N. Stevens D. A. Graybill J. R. Dismukes W. E. Cloud G. A. The NIAID Mycoses Study Group Ketoconazole therapy of progressive coccidioidomycosis. Comparisons of 400- and 800-mg doses and observations at higher doses. Am. J. Med. 84 1988 603 610","journal-title":"Am. J. Med."},{"key":"e_1_3_1_7_2","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1093\/infdis\/162.4.944","article-title":"Activity of cilofungin against Coccidioides immitis: differential in vitro effects on mycelia and spherules correlated with in vivo studies.","volume":"162","author":"Galgiani J. N.","year":"1990","unstructured":"Galgiani J. N. Sun S. H. Clemons K. V. Stevens D. A. Activity of cilofungin against Coccidioides immitis: differential in vitro effects on mycelia and spherules correlated with in vivo studies. J. Infect. Dis. 162 1990 944 948","journal-title":"J. Infect. Dis."},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/12.2.308"},{"key":"e_1_3_1_9_2","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/0002-9343(90)90339-F","article-title":"Itraconazole treatment of coccidioidomycosis.","volume":"89","author":"Graybill J. R.","year":"1990","unstructured":"Graybill J. R. Stevens D. A. Galgiani J. N. Dismukes W. E. Cloud G. A. The NIAID Mycoses Study Group Itraconazole treatment of coccidioidomycosis. Am. J. Med. 89 1990 282 290","journal-title":"Am. J. Med."},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.8.1775"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.1.151"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.32.9.1331"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.33.8.1391"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.38.7.1480"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/02681219780000961"},{"key":"e_1_3_1_16_2","unstructured":"National Committee for Clinical Laboratory Standards\n          Reference method for broth dilution antifungal susceptibility testing of conidium-forming filamentous fungi. Proposed standard. NCCLS document M38-P.\n          1998\n          National Committee for Clinical Laboratory Standards\n          Wayne Pa"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.15.6.1159-1160.1982"},{"key":"e_1_3_1_18_2","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1056\/NEJM199504203321607","article-title":"Coccidioidomycosis.","volume":"32","author":"Stevens D. A.","year":"1995","unstructured":"Stevens D. A. Coccidioidomycosis. N. Engl. J. Med. 32 1995 1077 1082","journal-title":"N. Engl. J. Med."},{"key":"e_1_3_1_19_2","doi-asserted-by":"crossref","first-page":"S380","DOI":"10.1093\/clinids\/12.Supplement_3.S380","article-title":"Treatment of coccidioidal meningitis with fluconazole.","volume":"12","author":"Tucker R. M.","year":"1990","unstructured":"Tucker R. M. Galgiani J. N. Denning D. W. Hanson L. H. Graybill J. R. Sharkey K. Eckman M. R. Salemi C. Libke R. Klein R. A. Stevens D., A. Treatment of coccidioidal meningitis with fluconazole. Rev. Infect. Dis. 12 (Suppl. 3) 1990 S380 S389","journal-title":"Rev. Infect. Dis."}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.45.6.1854-1859.2001","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.45.6.1854-1859.2001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T17:13:33Z","timestamp":1645463613000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.45.6.1854-1859.2001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,6]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2001,6]]}},"alternative-id":["10.1128\/AAC.45.6.1854-1859.2001"],"URL":"https:\/\/doi.org\/10.1128\/aac.45.6.1854-1859.2001","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,6]]},"assertion":[{"value":"2000-12-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-03-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-06-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}