{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:23:34Z","timestamp":1789431814738,"version":"build-2803163510"},"reference-count":45,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2001,7,1]],"date-time":"2001-07-01T00:00:00Z","timestamp":993945600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2001,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Since most nosocomial systemic yeast infections arise from the endogenous flora of the patient, we prospectively evaluated the species stratification and antifungal susceptibility profile of\n            <jats:italic>Candida<\/jats:italic>\n            spp. associated with heavy colonization and systemic infection in patients at Memorial Sloan-Kettering Cancer Center in New York. A total of 349\n            <jats:italic>Candida<\/jats:italic>\n            isolates were obtained from 223 patients during the later half of 1998. Cancer was the most common underlying disease, occurring in 91% of the patients, including 61.8% with organ and 23.7% with hematological malignancies; 4.4% of the patients had AIDS.\n            <jats:italic>Candida albicans<\/jats:italic>\n            was the predominant species (67.3%); among 114 non-\n            <jats:italic>albicans Candida<\/jats:italic>\n            spp.,\n            <jats:italic>C. glabrata<\/jats:italic>\n            (45.6%) was the most frequent, followed by\n            <jats:italic>C. tropicalis<\/jats:italic>\n            (18.4%),\n            <jats:italic>C. parapsilosis<\/jats:italic>\n            (16.6%), and\n            <jats:italic>C. krusei<\/jats:italic>\n            (9.6%). The overall resistance to triazole-based agents among all yeast isolates was 9.4 and 10.8% for fluconazole and itraconazole, respectively. A total of 5% of\n            <jats:italic>C. albicans<\/jats:italic>\n            strains were resistant to triazole antifungals, whereas 30.8 and 46.2% of\n            <jats:italic>C. glabrata<\/jats:italic>\n            strains were resistant to fluconazole (MIC \u2265 64 \u03bcg\/ml) and itraconazole (MIC \u2265 1 \u03bcg\/ml), respectively. A significant association was observed between prior treatment with triazole and isolation of fluconazole-resistant\n            <jats:italic>C. albicans<\/jats:italic>\n            (\n            <jats:italic>P<\/jats:italic>\n            = 0.005, OR 36), although this relationship was not seen in\n            <jats:italic>C. glabrata<\/jats:italic>\n            isolates (\n            <jats:italic>P<\/jats:italic>\n            = 0.4). This study reinforces the importance of periodic, prospective surveillance of clinical fungal isolates to determine appropriate prophylactic, empiric, and preemptive antifungal therapy for the highly susceptible patient population.\n          <\/jats:p>","DOI":"10.1128\/aac.45.7.2129-2133.2001","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:55:30Z","timestamp":1027763730000},"page":"2129-2133","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":78,"title":["Prospective Study of\n            <i>Candida<\/i>\n            Species in Patients at a Comprehensive Cancer Center"],"prefix":"10.1128","volume":"45","author":[{"given":"Amar","family":"Safdar","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Infectious Diseases Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center and Department of Medicine, Weill Medical College of Cornell University,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishnu","family":"Chaturvedi","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Mycology Laboratory, Axelrod Institute, New York State Department of Health, Albany,2 New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily W.","family":"Cross","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->The Public Health Research Institute,3 New York, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Park","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->The Public Health Research Institute,3 New York, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward M.","family":"Bernard","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Infectious Diseases Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center and Department of Medicine, Weill Medical College of Cornell University,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald","family":"Armstrong","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Infectious Diseases Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center and Department of Medicine, Weill Medical College of Cornell University,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Perlin","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->The Public Health Research Institute,3 New York, and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199754050-00002"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"S1591","DOI":"10.1093\/clinids\/11.Supplement_7.S1591","article-title":"Problems in management of opportunistic fungal diseases.","volume":"11","author":"Armstrong D.","year":"1989","unstructured":"Armstrong D. 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