{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:08:20Z","timestamp":1774570100571,"version":"3.50.1"},"reference-count":41,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2001,8,1]],"date-time":"2001-08-01T00:00:00Z","timestamp":996624000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2001,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The natural antibiotic susceptibilities to 71 antibiotics of 102\n            <jats:italic>Edwardsiella<\/jats:italic>\n            strains belonging to\n            <jats:italic>E. tarda<\/jats:italic>\n            (\n            <jats:italic>n<\/jats:italic>\n            = 42),\n            <jats:italic>E. ictaluri<\/jats:italic>\n            (\n            <jats:italic>n<\/jats:italic>\n            = 41), and\n            <jats:italic>E.<\/jats:italic>\n            <jats:italic>hoshinae<\/jats:italic>\n            (\n            <jats:italic>n<\/jats:italic>\n            = 19) were investigated. MICs were determined using a microdilution procedure according to NCCLS criteria and German standards. All edwardsiellae were naturally sensitive to tetracyclines, aminoglycosides, most \u03b2-lactams, quinolones, antifolates, chloramphenicol, nitrofurantoin, and fosfomycin.\n            <jats:italic>Edwardsiella<\/jats:italic>\n            species were naturally resistant to macrolides, lincosamides, streptogramins, glycopeptides, rifampin, fusidic acid, and oxacillin. Although slight species-dependent differences in natural susceptibilities to some antibiotics (e.g., macrolides and cefaclor) were seen, differences in natural susceptibility affecting clinical assessment criteria were only seen with benzylpenicillin. Whereas\n            <jats:italic>E. tarda<\/jats:italic>\n            was naturally resistant to benzylpenicillin,\n            <jats:italic>E. hoshinae<\/jats:italic>\n            was naturally sensitive. Natural sensitivity and resistance to this penicillin were found among the strains of\n            <jats:italic>E. ictaluri.<\/jats:italic>\n            The observed oxacillin sensitivity of\n            <jats:italic>E. ictaluri<\/jats:italic>\n            was attributed to the failure of the species to grow at higher salt concentrations found in oxacillin-containing microtiter plates. The present study describes a database concerning the natural susceptibility of\n            <jats:italic>Edwardsiella<\/jats:italic>\n            species to a wide range of antibiotics, which can be applied to validate forthcoming antibiotic susceptibility tests of these microorganisms.\n          <\/jats:p>","DOI":"10.1128\/aac.45.8.2245-2255.2001","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:56:57Z","timestamp":1027763817000},"page":"2245-2255","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":100,"title":["Natural Antibiotic Susceptibilities of\n            <i>Edwardsiella tarda<\/i>\n            ,\n            <i>E. ictaluri,<\/i>\n            and\n            <i>E. hoshinae<\/i>"],"prefix":"10.1128","volume":"45","author":[{"given":"Ingo","family":"Stock","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Institute of Medical Microbiology and Immunology, Pharmaceutical Microbiology, University of Bonn, Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd","family":"Wiedemann","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Institute of Medical Microbiology and Immunology, Pharmaceutical Microbiology, University of Bonn, Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1099\/00221287-144-6-1517","article-title":"Yersinia pseudotuberculosis and Yersinia pestis show increased outer membrane permeability to hydrophobic agents which correlates with lipopolysaccharide acyl-chain fluidity.","volume":"144","author":"Bengoechea J. 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Dis."},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1017\/S0022172400045812","article-title":"Edwardsiella tarda in a study of juvenile diarrhoea.","volume":"65","author":"Bhat P.","year":"1967","unstructured":"Bhat P. Myers M. Carpenter K. P. Edwardsiella tarda in a study of juvenile diarrhoea. J. Hyg. 65 1967 293 298","journal-title":"J. Hyg."},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0732-8893(91)90054-J","article-title":"In vitro susceptibilities of Edwardsiella tarda to 22 antibiotics and antibiotic-\u03b2-lactamase-inhibitor agents.","volume":"14","author":"Clark R. B.","year":"1991","unstructured":"Clark R. B. Lister P. D. Janda J. M. In vitro susceptibilities of Edwardsiella tarda to 22 antibiotics and antibiotic-\u03b2-lactamase-inhibitor agents. Diagn. Microbiol. Infect. Dis. 14 1991 173 175","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"e_1_3_2_6_2","first-page":"I","article-title":"Statement.","volume":"46","author":"Comit\u00e9 de l'Antibiogramme de la Soci\u00e9t\u00e9 Fran\u00e7aise de Microbiologie","year":"1998","unstructured":"Comit\u00e9 de l'Antibiogramme de la Soci\u00e9t\u00e9 Fran\u00e7aise de Microbiologie Statement. Pathol. Biol. 46 1998 I XVI","journal-title":"Pathol. Biol."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.15.3.332"},{"key":"e_1_3_2_8_2","unstructured":"Deutsches Institut f\u00fcr Normung e.V. 1998. Susceptibility testing of pathogens to antimicrobial agents part 4: evaluation classes of the minimum inhibitory concentration. Supplement 1: MIC breakpoints of antibacterial agents. Deutsches Institut f\u00fcr Normung document 58940\u20134. Deutsches Institut f\u00fcr Normung e.V. Berlin Germany. [In German.]"},{"key":"e_1_3_2_9_2","first-page":"33","article-title":"Edwardsiella, a new genus of Enterobacteriaceae based on a new species. 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Microbiol."},{"key":"e_1_3_2_31_2","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1099\/00222615-47-7-629","article-title":"Natural antibiotic susceptibility of Providencia stuartii,P. rettgeri,P. alcalifaciens and P. rustigianii strains.","volume":"47","author":"Stock I.","year":"1998","unstructured":"Stock I. Wiedemann B. Natural antibiotic susceptibility of Providencia stuartii,P. rettgeri,P. alcalifaciens and P. rustigianii strains. J. Med. Microbiol. 47 1998 629 642","journal-title":"J. Med. Microbiol."},{"key":"e_1_3_2_32_2","first-page":"219","article-title":"Natural antibiotic susceptibility of Yersinia pseudotuberculosis strains.","volume":"8","author":"Stock I.","year":"1999","unstructured":"Stock I. Wiedemann B. Natural antibiotic susceptibility of Yersinia pseudotuberculosis strains. Chemother. J. 8 1999 219 226 (In German.)","journal-title":"Chemother. J."},{"key":"e_1_3_2_33_2","first-page":"1","article-title":"Natural \u03b2-lactam susceptibility and mechanisms of \u03b2-lactam resistance in Yersinia enterocolitica strains.","volume":"38","author":"Stock I.","year":"2000","unstructured":"Stock I. Wiedemann B. Natural \u03b2-lactam susceptibility and mechanisms of \u03b2-lactam resistance in Yersinia enterocolitica strains. Rev. Med. Microbiol. 38 2000 1 14","journal-title":"Rev. Med. Microbiol."},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.65.9.3924-3932.1997"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0691.2000.00168.x"},{"key":"e_1_3_2_36_2","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3147\/jsfp.18.65","article-title":"Pathological activities of the naturally occurring strains of Edwardsiella tarda.","volume":"18","author":"Ullah M. A.","year":"1983","unstructured":"Ullah M. A. Arai T. 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