{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T20:23:17Z","timestamp":1793046197176,"version":"4.5.0"},"reference-count":6,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2001,8,1]],"date-time":"2001-08-01T00:00:00Z","timestamp":996624000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2001,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Animal studies have shown that fungal burden correlates with survival during treatment with new antifungal therapies for histoplasmosis. The purpose of this report is to compare the clearance of fungal burden in patients with histoplasmosis treated with liposomal amphotericin B versus itraconazole. In two separate closed clinical trials that evaluated the efficacy of liposomal amphotericin B and itraconazole treatment of disseminated histoplasmosis in patients with AIDS, blood was cultured for fungus and blood and urine were tested for<jats:italic>Histoplasma<\/jats:italic>antigen. The clinical response rates were similar; 86% with liposomal amphotericin B (<jats:italic>n<\/jats:italic>= 51) versus 85% with itraconazole (<jats:italic>n<\/jats:italic>= 59). Of the patients with positive blood cultures at enrollment, after 2 weeks of therapy cultures were negative in over 85% of the liposomal amphotericin B group versus 53% of the itraconazole group (<jats:italic>P<\/jats:italic>= 0.0008). Furthermore, after 2 weeks, median antigen levels in serum fell by 1.6 U in the liposomal amphotericin B group versus 0.1 U in the itraconazole group (<jats:italic>P<\/jats:italic>= 0.02), and those in urine fell by 2.1 U in the liposomal amphotericin B group and 0.2 U in the itraconazole group (<jats:italic>P<\/jats:italic>= 0.0005). The more rapid clearance of fungemia supports the use of liposomal amphotericin B rather than itraconazole for initial treatment of moderately severe or severe histoplasmosis.<\/jats:p>","DOI":"10.1128\/aac.45.8.2354-2357.2001","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:56:57Z","timestamp":1027763817000},"page":"2354-2357","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":91,"title":["Clearance of Fungal Burden during Treatment of Disseminated Histoplasmosis with Liposomal Amphotericin B versus Itraconazole"],"prefix":"10.1128","volume":"45","author":[{"given":"L. Joseph","family":"Wheat","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Indiana University School of Medicine,1"},{"name":"<!--label omitted: 2-->Histoplasmosis Reference Laboratory,2 and"},{"name":"<!--label omitted: 3-->Veterans' Affairs Medical Center,3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gretchen","family":"Cloud","sequence":"additional","affiliation":[{"name":"<!--label omitted: 4-->Indianapolis; Indiana, University of Alabama at Birmingham, Birmingham, Alabama4;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip C.","family":"Johnson","sequence":"additional","affiliation":[{"name":"<!--label omitted: 5-->University of Texas-Houston Medical School, Houston, Texas5; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Connolly","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Indiana University School of Medicine,1"},{"name":"<!--label omitted: 2-->Histoplasmosis Reference Laboratory,2 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell","family":"Goldman","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Indiana University School of Medicine,1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Le Monte","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Indiana University School of Medicine,1"},{"name":"<!--label omitted: 2-->Histoplasmosis Reference Laboratory,2 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deanna E.","family":"Fuller","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Indiana University School of Medicine,1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"Davis","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Indiana University School of Medicine,1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Hafner","sequence":"additional","affiliation":[{"name":"<!--label omitted: 6-->Division of AIDS, National Institute of Allergy and infectious Diseases, Rockville, Maryland6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The AIDS Clinical Trials Group The Mycoses Study Group Of NIAID","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression models and life-tables.","volume":"34","author":"Cox D. R.","year":"1972","unstructured":"Cox D. R. Regression models and life-tables. J. R. Stat. Soc. B34 1972 187 220","journal-title":"J. R. Stat. Soc."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.35.9.2252-2255.1997"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1958.10501452"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)80311-8"},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1086\/313752","article-title":"Practice guidelines for the management of patients with histoplasmosis.","volume":"30","author":"Wheat J.","year":"2000","unstructured":"Wheat J. Sarosi G. McKinsey D. Hamill R. Bradsher R. Johnson P. Loyd J. Kauffman C. Practice guidelines for the management of patients with histoplasmosis. Clin. Infect. Dis. 30 2000 688 695","journal-title":"Clin. Infect. Dis."},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"936","DOI":"10.7326\/0003-4819-115-12-936","article-title":"Histoplasmosis relapse in patients with AIDS: detection using Histoplasma capsulatum variety capsulatum antigen levels.","volume":"115","author":"Wheat L. J.","year":"1991","unstructured":"Wheat L. J. Connolly-Stringfield P. Blair R. Connolly K. Garringer T. Katz B. P. Histoplasmosis relapse in patients with AIDS: detection using Histoplasma capsulatum variety capsulatum antigen levels. Ann. Intern. Med. 115 1991 936 941","journal-title":"Ann. Intern. Med."}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.45.8.2354-2357.2001","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.45.8.2354-2357.2001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,8]],"date-time":"2024-12-08T19:52:06Z","timestamp":1733687526000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.45.8.2354-2357.2001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,8]]},"references-count":6,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2001,8]]}},"alternative-id":["10.1128\/AAC.45.8.2354-2357.2001"],"URL":"https:\/\/doi.org\/10.1128\/aac.45.8.2354-2357.2001","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,8]]},"assertion":[{"value":"2001-01-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-05-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-08-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}