{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T08:50:44Z","timestamp":1784191844906,"version":"3.55.0"},"reference-count":36,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2001,9,1]],"date-time":"2001-09-01T00:00:00Z","timestamp":999302400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2001,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            ABT-773 is a novel ketolide effective against antibacterial-resistant respiratory tract pathogens. The pharmacokinetic profile of ABT-773 was studied in rats and consisted of a mean peak concentration in plasma of 1.07 \u03bcg\/ml and an area under the concentration-time curve (AUC) of 12.03 \u03bcg\u2009\u00b7\u2009h\/ml when the compound was delivered at a dose of 25 mg\/kg of body weight. It concentrated in rat lung tissue, with a lung tissue-to-plasma ratio of 29 based on the AUC. In acute systemic infections in mice, ABT-773 showed efficacy against macrolide-susceptible strains of\n            <jats:italic>Staphylococcus aureus<\/jats:italic>\n            ,\n            <jats:italic>Streptococcus pneumoniae<\/jats:italic>\n            ,\n            <jats:italic>S. pyogenes<\/jats:italic>\n            , and\n            <jats:italic>Listeria monocytogenes<\/jats:italic>\n            . Additionally, ABT-773 improved the survival of mice infected with resistant\n            <jats:italic>S. pneumoniae<\/jats:italic>\n            containing either the\n            <jats:italic>ermB<\/jats:italic>\n            gene, the\n            <jats:italic>mefE<\/jats:italic>\n            gene, or altered penicillin binding protein genes. In a rat lung model of infection, ABT-773 demonstrated 50% effective doses lower than those of comparator macrolides when evaluated against the following strains of\n            <jats:italic>S. pneumoniae<\/jats:italic>\n            : a macrolide-lincosamide-streptogramin B-susceptible strain, an\n            <jats:italic>ermB<\/jats:italic>\n            strain, and an\n            <jats:italic>mefE<\/jats:italic>\n            strain\n            <jats:italic>.<\/jats:italic>\n            ABT-773 was also effective against\n            <jats:italic>Haemophilus influenzae<\/jats:italic>\n            lung infections in rats. Thus, ABT-773 may prove to be a useful new antibacterial agent for the treatment of respiratory tract infections.\n          <\/jats:p>","DOI":"10.1128\/aac.45.9.2585-2593.2001","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:55:30Z","timestamp":1027763730000},"page":"2585-2593","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":24,"title":["Efficacies of ABT-773, a New Ketolide, against Experimental Bacterial Infections"],"prefix":"10.1128","volume":"45","author":[{"given":"M. J.","family":"Mitten","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Infectious Diseases Research, Abbott Laboratories, Abbott Park, Illinois 60064-3537"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Meulbroek","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Infectious Diseases Research, Abbott Laboratories, Abbott Park, Illinois 60064-3537"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Nukkala","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Infectious Diseases Research, Abbott Laboratories, Abbott Park, Illinois 60064-3537"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Paige","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Infectious Diseases Research, Abbott Laboratories, Abbott Park, Illinois 60064-3537"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Jarvis","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Infectious Diseases Research, Abbott Laboratories, Abbott Park, Illinois 60064-3537"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Oleksijew","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Infectious Diseases Research, Abbott Laboratories, Abbott Park, Illinois 60064-3537"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Tovcimak","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Infectious Diseases Research, Abbott Laboratories, Abbott Park, Illinois 60064-3537"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Hernandez","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Infectious Diseases Research, Abbott Laboratories, Abbott Park, Illinois 60064-3537"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. D.","family":"Alder","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Infectious Diseases Research, Abbott Laboratories, Abbott Park, Illinois 60064-3537"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Ewing","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Infectious Diseases Research, Abbott Laboratories, Abbott Park, Illinois 60064-3537"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. S.","family":"Or","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Infectious Diseases Research, Abbott Laboratories, Abbott Park, Illinois 60064-3537"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Ma","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Infectious Diseases Research, Abbott Laboratories, Abbott Park, Illinois 60064-3537"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. M.","family":"Nilius","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Infectious Diseases Research, Abbott Laboratories, Abbott Park, Illinois 60064-3537"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Mollison","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Infectious Diseases Research, Abbott Laboratories, Abbott Park, Illinois 60064-3537"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. K.","family":"Flamm","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Infectious Diseases Research, Abbott Laboratories, Abbott Park, Illinois 60064-3537"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.10.2149"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1093\/jac\/31.2.303","article-title":"Comparative chemotherapeutic activity of temafloxacin, cefoxitin, clindamycin, imipenem and ampicillin\/sulbactam against Bacteroides fragilis in a mouse subcutaneous abscess model.","volume":"31","author":"Alder J.","year":"1993","unstructured":"Alder J. Clement J. Comparative chemotherapeutic activity of temafloxacin, cefoxitin, clindamycin, imipenem and ampicillin\/sulbactam against Bacteroides fragilis in a mouse subcutaneous abscess model. J. Antimicrob. Chemother. 31 1993 303 311","journal-title":"J. Antimicrob. Chemother."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.4.971"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.9.2385"},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1007\/BF01709263","article-title":"In vitro activity of the new ketolide HMR 3004 compared to an azalide and macrolides against Streptococcus pneumoniae and Haemophilus influenzae.","volume":"16","author":"Barry A. L.","year":"1997","unstructured":"Barry A. L. Fuchs P. C. Brown S. D. In vitro activity of the new ketolide HMR 3004 compared to an azalide and macrolides against Streptococcus pneumoniae and Haemophilus influenzae. Eur. J. Clin. Microbiol. Infect. Dis. 16 1997 767 769","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0732-8893(98)00022-4","article-title":"Comparative antimicrobial activity and kill-curve investigations of novel ketolide antimicrobial drugs (HMR 3004 and HMR 3647) tested against Haemophilus influenzae and Moraxella catarrhalis strains.","volume":"31","author":"Biedenbach D. J.","year":"1998","unstructured":"Biedenbach D. J. Barrett M. S. Jones R. N. Comparative antimicrobial activity and kill-curve investigations of novel ketolide antimicrobial drugs (HMR 3004 and HMR 3647) tested against Haemophilus influenzae and Moraxella catarrhalis strains. Diagn. Microbiol. Infect. Dis. 31 1998 349 353","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1001\/jama.1994.03510470035031","article-title":"Emergence of drug-resistance pneumococcal infections in the United States.","volume":"271","author":"Breiman R. F.","year":"1994","unstructured":"Breiman R. F. Butler J. C. Tenover F. C. Eliott J. A. Facklam R. R. Emergence of drug-resistance pneumococcal infections in the United States. JAMA 271 1994 1831 1835","journal-title":"JAMA"},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1128\/AAC.44.2.447-449.2000","article-title":"In vivo activity of ABT-773, a new ketolide, against recent clinical isolates of Streptococcus pneumoniae,Haemophilus influenzae, and Moraxella catarrhalis.","volume":"44","author":"Brueggeman A. B.","year":"2000","unstructured":"Brueggeman A. B. Doern G. Huynh H. Wingert E. Rhomberg P. In vivo activity of ABT-773, a new ketolide, against recent clinical isolates of Streptococcus pneumoniae,Haemophilus influenzae, and Moraxella catarrhalis. Antimicrob. Agents Chemother. 44 2000 447 449","journal-title":"Antimicrob. Agents Chemother."},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.6.1562-1567.2000"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1369-5274(99)00002-8"},{"key":"e_1_3_2_12_2","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1007\/s100960050337","article-title":"Influence of increased macrolide consumption on macrolide resistance of common respiratory pathogens.","volume":"18","author":"Cizman M.","year":"1999","unstructured":"Cizman M. Pokorn M. Seme K. Paragi M. Orazem A. Influence of increased macrolide consumption on macrolide resistance of common respiratory pathogens. Eur. J. Clin. Microbiol. Infect. Dis. 18 1999 522 524","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.38.5.1071"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.2.334"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.9.2144"},{"key":"e_1_3_2_16_2","doi-asserted-by":"crossref","first-page":"757","DOI":"10.3201\/eid0506.990603","article-title":"Antimicrobial resistance with Streptococcus pneumoniae in the United States, 1997\u20131998.","volume":"5","author":"Doern G. V.","year":"1999","unstructured":"Doern G. V. Brueggemann A. B. Huynh H. Wingert E. Rhomberg P. Antimicrobial resistance with Streptococcus pneumoniae in the United States, 1997\u20131998. Emerg. Infect. Dis. 5 1999 757 765","journal-title":"Emerg. Infect. Dis."},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.2.292"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.5.1208"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.4.795"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.31.11.1768"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.9.2425"},{"key":"e_1_3_2_22_2","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1093\/jac\/44.4.461","article-title":"Macrolide resistance mechanisms and expression of phenotypes among Streptococcus pneumonia circulating in Italy.","volume":"44","author":"Marchese A.","year":"1999","unstructured":"Marchese A. Tonoli E. Debbia E. Schito G. Macrolide resistance mechanisms and expression of phenotypes among Streptococcus pneumonia circulating in Italy. J. Antimicrob. Chemother. 44 1999 461 465","journal-title":"J. Antimicrob. Chemother."},{"key":"e_1_3_2_23_2","unstructured":"National Committee for Clinical Laboratory Standards\n          Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. Approved standard M7A4.\n          1997\n          National Committee for Clinical Laboratory Stanards\n          Wayne Pa"},{"key":"e_1_3_2_24_2","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1097\/00006454-199704000-00027","article-title":"Pharmacokinetics and pharmacodynamics of newer macrolides.","volume":"16","author":"Nightingale C. H.","year":"1997","unstructured":"Nightingale C. H. Pharmacokinetics and pharmacodynamics of newer macrolides. Pediatr. Infect. Dis. J. 16 1997 438 443","journal-title":"Pediatr. Infect. Dis. J."},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.7.2163-2168.2001"},{"key":"e_1_3_2_26_2","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1021\/jm990618n","article-title":"Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against respiratory tract pathogens.","volume":"43","author":"Or Y. S.","year":"2000","unstructured":"Or Y. S. Clark R. Wang S. Chu D. T. Nilius A. Flamm R. Mitten M. Ewing P. Alder J. Ma Z. Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against respiratory tract pathogens. J. Med. Chem. 43 2000 1045 1049","journal-title":"J. Med. Chem."},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.10.2510"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.3.708"},{"key":"e_1_3_2_29_2","doi-asserted-by":"crossref","unstructured":"Rao\n              C. R.\n          Linear statistical inference and its applications.\n          1973\n          Wiley\n          New York N.Y","DOI":"10.1002\/9780470316436"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.6.1399"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.32.4.906-911.1994"},{"key":"e_1_3_2_32_2","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1086\/313452","article-title":"Prevalence of macrolide resistance mechanisms in Streptococcus pneumoniae isolates from multicenter antibiotic resistance surveillance study conducted in the United States in 1994\u20131995.","volume":"29","author":"Shortridge V. D.","year":"1999","unstructured":"Shortridge V. D. Doern G. Brueggeman A. Beyer J. Flamm R. Prevalence of macrolide resistance mechanisms in Streptococcus pneumoniae isolates from multicenter antibiotic resistance surveillance study conducted in the United States in 1994\u20131995. Clin. Infect. Dis. 29 1999 1186 1189","journal-title":"Clin. Infect. Dis."},{"key":"e_1_3_2_33_2","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1177\/070674379604100805","article-title":"Maintaining standards: differences between the standard deviation and standard error, and when to use each.","volume":"41","author":"Streiner D. L.","year":"1996","unstructured":"Streiner D. L. Maintaining standards: differences between the standard deviation and standard error, and when to use each. Can. J. Psychiatr. 41 1996 498 502","journal-title":"Can. J. Psychiatr."},{"key":"e_1_3_2_34_2","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0732-8893(97)00195-8","article-title":"Surveillance of antimicrobial resistance in Streptococcus pneumoniae,Haemophilus influenzae,and Moraxella catarrhalis in the United States in 1996\u20131997 respiratory season.","volume":"29","author":"Thornsberry C.","year":"1997","unstructured":"Thornsberry C. Ogilvie P. Kahn J. Mauriz Y. the Laboratory Investigator Group Surveillance of antimicrobial resistance in Streptococcus pneumoniae,Haemophilus influenzae,and Moraxella catarrhalis in the United States in 1996\u20131997 respiratory season. Diagn. Microbiol. Infect. Dis. 29 1997 249 257","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.10.2504"},{"key":"e_1_3_2_36_2","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1089\/mdr.1999.5.183","article-title":"Induction of ribosome methylation in MLS-resistant Streptococcus pneumoniae by macrolides and ketolides.","volume":"5","author":"Zhong P.","year":"1999","unstructured":"Zhong P. Cao Z. Hammond R. Chen Y. Beyer J. Shortridge V. Phan L. Pratt S. Capobianco J. Reich K. Flamm R. Or Y. Katz L. Induction of ribosome methylation in MLS-resistant Streptococcus pneumoniae by macrolides and ketolides. Microb. Drug Resist. 5 1999 183 188","journal-title":"Microb. Drug Resist."},{"key":"e_1_3_2_37_2","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/S0891-5520(20)30694-2","article-title":"The newer macrolides azithromycin and clarithromycin.","volume":"9","author":"Zuckerman J. M.","year":"1995","unstructured":"Zuckerman J. M. Kaye K. M. The newer macrolides azithromycin and clarithromycin. Infect. Dis. Clin. N. Am. 9 1995 731 745","journal-title":"Infect. Dis. Clin. N. Am."}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.45.9.2585-2593.2001","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.45.9.2585-2593.2001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T17:11:07Z","timestamp":1645463467000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.45.9.2585-2593.2001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,9]]},"references-count":36,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2001,9]]}},"alternative-id":["10.1128\/AAC.45.9.2585-2593.2001"],"URL":"https:\/\/doi.org\/10.1128\/aac.45.9.2585-2593.2001","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,9]]},"assertion":[{"value":"2000-10-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-06-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}