{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T09:31:55Z","timestamp":1780479115362,"version":"3.54.1"},"reference-count":37,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2001,9,1]],"date-time":"2001-09-01T00:00:00Z","timestamp":999302400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2001,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The stability and compatibility of ceftazidime have been examined in the context of its potential use in concentrated solutions for continuous infusion in patients suffering from severe nosocomial pneumonia and receiving other intravenous medications by the same route. Ceftazidime stability in 4 to 12% solutions was found satisfactory (&lt;10% degradation) for 24 h if kept at a temperature of 25\u00b0C (77\u00b0F) maximum. Studies mimicking the simultaneous administration of ceftazidime and other drugs as done in clinics showed physical incompatibilities with vancomycin, nicardipine, midazolam, and propofol and a chemical incompatibility with\n            <jats:italic>N<\/jats:italic>\n            -acetylcystein. Concentrated solutions (50 mg\/ml) of erythromycin or clarithromycin caused the appearance of a precipitate, whereas gentamicin, tobramycin, amikacin, isepamicin, fluconazole, ketamine, sufentanil, valproic acid, furosemide, uradipil, and a standard amino acid solution were physically and chemically compatible.\n          <\/jats:p>","DOI":"10.1128\/aac.45.9.2643-2647.2001","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:55:30Z","timestamp":1027763730000},"page":"2643-2647","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":50,"title":["Stability and Compatibility of Ceftazidime Administered by Continuous Infusion to Intensive Care Patients"],"prefix":"10.1128","volume":"45","author":[{"given":"He\u0301le\u0300ne","family":"Servais","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Unite\u0301 de Pharmacologie Cellulaire et Mole\u0301culaire, Universite\u0301 catholique de Louvain, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Tulkens","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Unite\u0301 de Pharmacologie Cellulaire et Mole\u0301culaire, Universite\u0301 catholique de Louvain, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","unstructured":"Anonymous\n          Ceftazidime for injection\n          United States Pharmacopeial Convention (ed.) United States pharmacopeia (the national formulary).\n          1995\n          310\n          United States Pharmacopeial Convention\n          Rockville Md"},{"key":"e_1_3_2_3_2","first-page":"389","article-title":"Compatibility of ondansetron hydrochloride with fluconazole, ceftazidime, aztreonam, and cefazolin sodium under simulated Y-site conditions.","volume":"51","author":"Bosso J. A.","year":"1994","unstructured":"Bosso J. A. Prince R. A. Fox J. L. Compatibility of ondansetron hydrochloride with fluconazole, ceftazidime, aztreonam, and cefazolin sodium under simulated Y-site conditions. Am. J. Hosp. Pharm. 51 1994 389 391","journal-title":"Am. J. Hosp. Pharm."},{"key":"e_1_3_2_4_2","first-page":"309","article-title":"Intramolecular nucleophilic attack of an ureido group on the beta-lactam carbonyl moiety of penicillins.","volume":"10","author":"Bundgaard H.","year":"1973","unstructured":"Bundgaard H. Intramolecular nucleophilic attack of an ureido group on the beta-lactam carbonyl moiety of penicillins. Acta Pharm. Suec. 10 1973 309 316","journal-title":"Acta Pharm. 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