{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:39:56Z","timestamp":1773283196333,"version":"3.50.1"},"reference-count":17,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2001,9,1]],"date-time":"2001-09-01T00:00:00Z","timestamp":999302400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2001,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            We report two South African serotype 6B pneumococcal isolates with cephalosporin resistance, yet with susceptibility to penicillin. DNA fingerprinting revealed that they were clonal in origin.\n            <jats:italic>pbp 2X<\/jats:italic>\n            and\n            <jats:italic>1A<\/jats:italic>\n            genes showed major alterations typical of cephalosporin-resistant pneumococci. The\n            <jats:italic>pbp 2B<\/jats:italic>\n            gene was completely unaltered, explaining the penicillin susceptibility of the isolates.\n          <\/jats:p>","DOI":"10.1128\/aac.45.9.2648-2650.2001","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:06:42Z","timestamp":1027764402000},"page":"2648-2650","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":24,"title":["Emergence of a Pneumococcal Clone with Cephalosporin Resistance and Penicillin Susceptibility"],"prefix":"10.1128","volume":"45","author":[{"given":"Anthony M.","family":"Smith","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->MRC\/SAIMR\/WITS Pneumococcal Diseases Research Unit, Department of Clinical Microbiology and Infectious Diseases, South African Institute for Medical Research, Johannesburg,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roelof F.","family":"Botha","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Microbiology Department, Drs. du Buisson, Bruinette, and Kramer, Pretoria,2 South Africa, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hendrik J.","family":"Koornhof","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->MRC\/SAIMR\/WITS Pneumococcal Diseases Research Unit, Department of Clinical Microbiology and Infectious Diseases, South African Institute for Medical Research, Johannesburg,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith P.","family":"Klugman","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->MRC\/SAIMR\/WITS Pneumococcal Diseases Research Unit, Department of Clinical Microbiology and Infectious Diseases, South African Institute for Medical Research, Johannesburg,1 and"},{"name":"<!--label omitted: 3-->Departments of International Health and Infectious Diseases, Emory University, Atlanta, Georgia3"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.1574-6968.1995.tb07433.x","article-title":"Genetics of high level penicillin resistance in clinical isolates of Streptococcus pneumoniae.","volume":"126","author":"Barcus V. A.","year":"1995","unstructured":"Barcus V. A. Ghanckar K. Yeo M. Coffey T. J. Dowson C. G. Genetics of high level penicillin resistance in clinical isolates of Streptococcus pneumoniae. FEMS Microbiol. Lett. 126 1995 299 303","journal-title":"FEMS Microbiol. Lett."},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.22.8842"},{"key":"e_1_3_1_4_2","doi-asserted-by":"crossref","first-page":"4891","DOI":"10.1073\/pnas.080067697","article-title":"Inhibition of the expression of penicillin resistance in Streptococcus pneumoniae by inactivation of cell wall muropeptide branching genes.","volume":"97","author":"Filipe S. R.","year":"2000","unstructured":"Filipe S. R. Tomasz A. Inhibition of the expression of penicillin resistance in Streptococcus pneumoniae by inactivation of cell wall muropeptide branching genes. Proc. Natl. Acad. Sci. USA 97 2000 4891 4896","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.173.22.7361-7367.1991"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.5.4.408"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1991.tb00821.x"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.31.10.2724-2728.1993"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.174.13.4517-4523.1992"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1992.tb01422.x"},{"key":"e_1_3_1_11_2","unstructured":"National Committee for Clinical Laboratory Standards\n          Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. Approved standard M7\u2013A5\n          5th ed.\n          2000\n          NCCLS\n          Wayne Pa"},{"key":"e_1_3_1_12_2","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1111\/j.1365-2958.1994.tb01089.x","article-title":"Mosaic pbpX genes of major clones of penicillin-resistant Streptococcus pneumoniae have evolved from pbpX genes of a penicillin-sensitive Streptococcus oralis.","volume":"12","author":"Sibold C.","year":"1994","unstructured":"Sibold C. Henrichsen J. Konig A. Martin C. Chalkley L. Hakenbeck R. Mosaic pbpX genes of major clones of penicillin-resistant Streptococcus pneumoniae have evolved from pbpX genes of a penicillin-sensitive Streptococcus oralis. Mol. Microbiol. 12 1994 1013 1023","journal-title":"Mol. Microbiol."},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.6.1329"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.8.2393-2396.2001"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.37.9.1938"},{"key":"e_1_3_1_16_2","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1073\/pnas.51.3.480","article-title":"Regulation of the transformability of pneumococcal cultures by macromolecular cell products.","volume":"51","author":"Tomasz A.","year":"1964","unstructured":"Tomasz A. Hotchkiss R. D. Regulation of the transformability of pneumococcal cultures by macromolecular cell products. Proc. Natl. Acad. Sci. USA 51 1964 480 487","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.52.070183.004141"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.17.3.434"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.45.9.2648-2650.2001","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.45.9.2648-2650.2001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T17:08:02Z","timestamp":1645463282000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.45.9.2648-2650.2001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,9]]},"references-count":17,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2001,9]]}},"alternative-id":["10.1128\/AAC.45.9.2648-2650.2001"],"URL":"https:\/\/doi.org\/10.1128\/aac.45.9.2648-2650.2001","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,9]]},"assertion":[{"value":"2001-01-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-06-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}