{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T11:07:17Z","timestamp":1764587237761},"reference-count":36,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T00:00:00Z","timestamp":1033430400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2002,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Since the 1990s, the substantial increase in the rate of\n            <jats:italic>Candida glabrata<\/jats:italic>\n            infections has become a serious problem. As most\n            <jats:italic>C. glabrata<\/jats:italic>\n            infections arise from the host's endogenous microflora, the present prospective, multicenter analysis included all clinical isolates associated with colonization and with systemic and hematogenous candidiasis. Among 347\n            <jats:italic>C. glabrata<\/jats:italic>\n            isolates, the overall rates of resistance to fluconazole (MIC \u2265 64 \u03bcg\/ml) and itraconazole (MIC \u2265 1 \u03bcg\/ml) were 10.7 and 15.2%, respectively, although for half (\n            <jats:italic>n<\/jats:italic>\n            = 148) of the itraconazole-susceptible isolates the MICs (0.25 to 0.5 \u03bcg\/ml) were in the susceptible\u2014dependent upon dose range. Fluconazole resistance was more common among\n            <jats:italic>C. glabrata<\/jats:italic>\n            isolates obtained from centers caring for patients with cancer (MICs at which 90% of isolates are inhibited [MIC\n            <jats:sub>90<\/jats:sub>\n            s] = 32 \u03bcg\/ml) or AIDS (MIC\n            <jats:sub>90<\/jats:sub>\n            s &gt; 64 \u03bcg\/ml) than among\n            <jats:italic>C. glabrata<\/jats:italic>\n            isolates from a community-based university medical center (MIC\n            <jats:sub>90<\/jats:sub>\n            s = 16 \u03bcg\/ml) (\n            <jats:italic>P<\/jats:italic>\n            = 0.001). Thirty-three bloodstream isolates and those obtained from other body sites had similar in vitro susceptibility profiles. The fluconazole MIC\n            <jats:sub>90<\/jats:sub>\n            s (\u226416 \u03bcg\/ml) for\n            <jats:italic>C. glabrata<\/jats:italic>\n            yeast isolates from the gastrointestinal tract were lower than those (\u226564 \u03bcg\/ml) for\n            <jats:italic>C. glabrata<\/jats:italic>\n            isolates from respiratory and urinary tract samples (\n            <jats:italic>P<\/jats:italic>\n            = 0.01). A similar discrepancy for itraconazole was not significant (\n            <jats:italic>P<\/jats:italic>\n            &gt; 0.5). We did not observe differences in fluconazole or itraconazole susceptibility profiles among\n            <jats:italic>C. glabrata<\/jats:italic>\n            isolates associated with either hematogenous dissemination or colonization. The significant discrepancy in antifungal susceptibility among\n            <jats:italic>C. glabrata<\/jats:italic>\n            organisms isolated from hospitals in the same geographic region emphasizes the significance of periodic susceptibility surveillance programs for individual institutions, especially those providing care to patients at risk.\n          <\/jats:p>","DOI":"10.1128\/aac.46.10.3268-3272.2002","type":"journal-article","created":{"date-parts":[[2002,9,16]],"date-time":"2002-09-16T19:23:02Z","timestamp":1032204182000},"page":"3268-3272","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":38,"title":["Prospective, Multicenter Surveillance Study of\n            <i>Candida glabrata<\/i>\n            : Fluconazole and Itraconazole Susceptibility Profiles in Bloodstream, Invasive, and Colonizing Strains and Differences between Isolates from Three Urban Teaching Hospitals in New York City (\n            <i>Candida<\/i>\n            Susceptibility Trends Study, 1998 to 1999)"],"prefix":"10.1128","volume":"46","author":[{"given":"Amar","family":"Safdar","sequence":"first","affiliation":[{"name":"Infectious Diseases Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center"},{"name":"Department of Medicine, Weill Medical College of Cornell University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vishnu","family":"Chaturvedi","sequence":"additional","affiliation":[{"name":"Mycology Laboratory, New York State Department of Health, Albany, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian S.","family":"Koll","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Beth Israel Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davise H.","family":"Larone","sequence":"additional","affiliation":[{"name":"Clinical Microbiology Laboratory, New York Weill Cornell Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David S.","family":"Perlin","sequence":"additional","affiliation":[{"name":"The Public Health Research Institute, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center"},{"name":"Department of Medicine, Weill Medical College of Cornell University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.17.2659"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/513663"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.5.1163"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/167.5.1247"},{"key":"e_1_3_2_6_2","first-page":"60","volume":"13","year":"2000","unstructured":"Bernal, S., M. 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