{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T12:26:34Z","timestamp":1697372794584},"reference-count":6,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2002,12,1]],"date-time":"2002-12-01T00:00:00Z","timestamp":1038700800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2002,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>To assess the relationship between antiretroviral drug exposure and lipodystrophy, 69 human immunodeficiency virus type 1-infected patients receiving nelfinavir were investigated cross-sectionally. Lipodystrophy was defined by patients' self-report. Nelfinavir trough concentrations in plasma were significantly related to overall lipodystrophy and peripheral fat wasting scores and appeared to be an independent risk factor for lipodystrophy<\/jats:p>","DOI":"10.1128\/aac.46.12.4009-4012.2002","type":"journal-article","created":{"date-parts":[[2002,11,15]],"date-time":"2002-11-15T20:02:26Z","timestamp":1037390546000},"page":"4009-4012","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":15,"title":["High Concentrations of Nelfinavir as an Independent Risk Factor for Lipodystrophy in Human Immunodeficiency Virus-Infected Patients"],"prefix":"10.1128","volume":"46","author":[{"given":"Jean-Marc","family":"Tre\u0301luyer","sequence":"first","affiliation":[{"name":"Pharmacologie Pe\u0301rinatale et Pe\u0301diatrique"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Pierre","family":"Morini","sequence":"additional","affiliation":[{"name":"Dermatologie-Ve\u0301ne\u0301rologie, Groupe Hospitalier Cochin-Saint Vincent de Paul (AP-HP), Universite\u0301 Rene\u0301 Descartes, 75674 Paris Cedex 14, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Je\u0301rome","family":"Dimet","sequence":"additional","affiliation":[{"name":"Pharmacologie Pe\u0301rinatale et Pe\u0301diatrique"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Gorin","sequence":"additional","affiliation":[{"name":"Dermatologie-Ve\u0301ne\u0301rologie, Groupe Hospitalier Cochin-Saint Vincent de Paul (AP-HP), Universite\u0301 Rene\u0301 Descartes, 75674 Paris Cedex 14, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Rey","sequence":"additional","affiliation":[{"name":"Pharmacologie Pe\u0301rinatale et Pe\u0301diatrique"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Deleuze","sequence":"additional","affiliation":[{"name":"Dermatologie-Ve\u0301ne\u0301rologie, Groupe Hospitalier Cochin-Saint Vincent de Paul (AP-HP), Universite\u0301 Rene\u0301 Descartes, 75674 Paris Cedex 14, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre-Franc\u0327ois","family":"Ceccaldi","sequence":"additional","affiliation":[{"name":"Pharmacologie Pe\u0301rinatale et Pe\u0301diatrique"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Paul","family":"Escande","sequence":"additional","affiliation":[{"name":"Dermatologie-Ve\u0301ne\u0301rologie, Groupe Hospitalier Cochin-Saint Vincent de Paul (AP-HP), Universite\u0301 Rene\u0301 Descartes, 75674 Paris Cedex 14, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ge\u0301rard","family":"Pons","sequence":"additional","affiliation":[{"name":"Pharmacologie Pe\u0301rinatale et Pe\u0301diatrique"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Dupin","sequence":"additional","affiliation":[{"name":"Dermatologie-Ve\u0301ne\u0301rologie, Groupe Hospitalier Cochin-Saint Vincent de Paul (AP-HP), Universite\u0301 Rene\u0301 Descartes, 75674 Paris Cedex 14, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0169-2607(00)00127-9","volume":"65","year":"2001","unstructured":"Aboul-Seoud, M. 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