{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:24:59Z","timestamp":1791192299440,"version":"4.1.0"},"reference-count":21,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2002,2,1]],"date-time":"2002-02-01T00:00:00Z","timestamp":1012521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2002,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The activity of CS-758 (R-120758), a new triazole antifungal agent, was evaluated and compared with those of fluconazole, itraconazole, and amphotericin B in vitro and with those of fluconazole and itraconazole in vivo. CS-758 exhibited potent in vitro activity against clinically important fungi. The activity of CS-758 against\n            <jats:italic>Candida<\/jats:italic>\n            spp. was superior to that of fluconazole and comparable or superior to those of itraconazole and amphotericin B. CS-758 retained potent activity against\n            <jats:italic>Candida albicans<\/jats:italic>\n            strains with low levels of susceptibility to fluconazole (fluconazole MIC, 4 to 32 \u03bcg\/ml). Against\n            <jats:italic>Aspergillus<\/jats:italic>\n            spp. and\n            <jats:italic>Cryptococcus neoformans<\/jats:italic>\n            , the activity of CS-758 was at least fourfold superior to those of the other drugs tested. CS-758 also exhibited potent in vivo activity against murine systemic infections caused by\n            <jats:italic>C. albicans<\/jats:italic>\n            ,\n            <jats:italic>C. neoformans<\/jats:italic>\n            ,\n            <jats:italic>Aspergillus fumigatus<\/jats:italic>\n            , and\n            <jats:italic>Aspergillus flavus<\/jats:italic>\n            . The 50% effective doses against these infections were 0.41 to 5.0 mg\/kg of body weight. These results suggest that CS-758 may be useful in the treatment of candidiasis, cryptococcosis, and aspergillosis.\n          <\/jats:p>","DOI":"10.1128\/aac.46.2.367-370.2002","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:06:42Z","timestamp":1027764402000},"page":"367-370","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":21,"title":["In Vitro and In Vivo Activities of CS-758 (R-120758), a New Triazole Antifungal Agent"],"prefix":"10.1128","volume":"46","author":[{"given":"Yasuki","family":"Kamai","sequence":"first","affiliation":[{"name":"Biological Research Laboratories, Sankyo Co., Ltd., Shinagawa-ku, Tokyo 140-8710"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamako","family":"Harasaki","sequence":"additional","affiliation":[{"name":"Biological Research Laboratories, Sankyo Co., Ltd., Shinagawa-ku, Tokyo 140-8710"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Fukuoka","sequence":"additional","affiliation":[{"name":"Biological Research Laboratories, Sankyo Co., Ltd., Shinagawa-ku, Tokyo 140-8710"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Ohya","sequence":"additional","affiliation":[{"name":"Biological Research Laboratories, Sankyo Co., Ltd., Shinagawa-ku, Tokyo 140-8710"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhisa","family":"Uchida","sequence":"additional","affiliation":[{"name":"Teikyo University Institute of Medical Mycology, Hachioji, Tokyo 192-0395"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyo","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Teikyo University Institute of Medical Mycology, Hachioji, Tokyo 192-0395"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shogo","family":"Kuwahara","sequence":"additional","affiliation":[{"name":"Toho University School of Medicine, Ohta-ku, Tokyo 143-8540, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/44.2.151"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(91)90349-3"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/43.2.295"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/167.5.1247"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1086\/513943"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.12.3065"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.9.3.593"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.12.2.310"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/24.1.28"},{"key":"e_1_3_1_11_2","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1348-0421.1998.tb01970.x","volume":"42","year":"1998","unstructured":"Makimura, K., T. 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