{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T12:55:34Z","timestamp":1773752134753,"version":"3.50.1"},"reference-count":51,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2002,3,1]],"date-time":"2002-03-01T00:00:00Z","timestamp":1014940800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2002,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Of 15 extended-spectrum \u03b2-lactamase (ESBL)-producing isolates of the family\n            <jats:italic>Enterobacteriaceae<\/jats:italic>\n            collected from the First Municipal People's Hospital of Guangzhou, in the southern part of the People's Republic of China, 9 were found to produce CTX-M ESBLs, 3 produced SHV-12, and 3 produced both CTX-M and SHV-12. Eleven isolates produced either TEM-1B or SHV-11, in addition to an ESBL. Nucleotide sequence analysis of the 12 isolates carrying\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>CTX-M<\/jats:sub>\n            genes revealed that they harbored three different\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>CTX-M<\/jats:sub>\n            genes,\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>CTX-M-9<\/jats:sub>\n            (5 isolates),\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>CTX-M-13<\/jats:sub>\n            (1 isolate), and\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>CTX-M-14<\/jats:sub>\n            (6 isolates). These genes have 98% nucleotide homology with\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>Toho-2<\/jats:sub>\n            . The\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>CTX-M<\/jats:sub>\n            genes were carried on plasmids that ranged in size from 35 to 150 kb. Plasmid fingerprints and pulsed-field gel electrophoresis showed the dissemination of the\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>CTX-M<\/jats:sub>\n            genes through transfer of different antibiotic resistance plasmids to different bacteria, suggesting that these resistance determinants are highly mobile. Insertion sequence IS\n            <jats:italic>Ecp1<\/jats:italic>\n            , found on the upstream region of these genes, may be involved in the translocation of the\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>CTX-M<\/jats:sub>\n            genes. This is the first report of the occurrence of SHV-12 and CTX-M ESBLs in China. The presence of strains with these ESBLs shows both the evolution of\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>CTX-M<\/jats:sub>\n            genes and their dissemination among at least three species of the family\n            <jats:italic>Enterobacteriaceae<\/jats:italic>\n            ,\n            <jats:italic>Escherichia coli<\/jats:italic>\n            ,\n            <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n            , and\n            <jats:italic>Enterobacter cloacae<\/jats:italic>\n            , isolated within a single hospital. The predominance of CTX-M type enzymes seen in this area of China appears to be similar to that seen in South America but is different from those seen in Europe and North America, suggesting different evolutionary routes and selective pressures. A more comprehensive survey of the ESBL types from China is urgently needed.\n          <\/jats:p>","DOI":"10.1128\/aac.46.3.630-637.2002","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:56:57Z","timestamp":1027763817000},"page":"630-637","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":171,"title":["Three Cefotaximases, CTX-M-9, CTX-M-13, and CTX-M-14, among\n            <i>Enterobacteriaceae<\/i>\n            in the People's Republic of China"],"prefix":"10.1128","volume":"46","author":[{"given":"Aroonwadee","family":"Chanawong","sequence":"first","affiliation":[{"name":"Division of Microbiology, University of Leeds, Leeds LS2 9JT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatima Hannachi","family":"M'Zali","sequence":"additional","affiliation":[{"name":"Division of Microbiology, University of Leeds, Leeds LS2 9JT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Heritage","sequence":"additional","affiliation":[{"name":"Division of Microbiology, University of Leeds, Leeds LS2 9JT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Hui","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Immunity and Infection, The Medical School, University of Birmingham, Birmingham B15 2TT, United Kingdom"},{"name":"First Municipal People's Hospital of Guangzhou, Guangzhou 510180, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter Michael","family":"Hawkey","sequence":"additional","affiliation":[{"name":"Division of Microbiology, University of Leeds, Leeds LS2 9JT"},{"name":"Department of Immunity and Infection, The Medical School, University of Birmingham, Birmingham B15 2TT, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2760269"},{"key":"e_1_3_2_3_2","first-page":"203","volume":"134","year":"1995","unstructured":"Arlet, G., G. 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