{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:16:06Z","timestamp":1790788566754,"version":"4.1.0"},"reference-count":14,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2002,3,1]],"date-time":"2002-03-01T00:00:00Z","timestamp":1014940800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2002,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Antimicrobial resistance is an emerging problem with\n            <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n            . This study determined risk factors for the recovery of piperacillin-tazobactam-resistant\n            <jats:italic>P. aeruginosa<\/jats:italic>\n            from clinical cultures from hospitalized patients. A case-control study design was used to compare two groups of case patients with control patients. The first group of case patients was defined by nosocomial isolation of piperacillin-tazobactam-resistant\n            <jats:italic>P. aeruginosa<\/jats:italic>\n            , and the second group of cases yielded piperacillin-tazobactam-susceptible\n            <jats:italic>P. aeruginosa<\/jats:italic>\n            . Controls were selected in a 6:1 ratio from the same medical or surgical services among which piperacillin-tazobactam-resistant\n            <jats:italic>P. aeruginosa<\/jats:italic>\n            arose in patients. Risk factors analyzed included antimicrobial drug exposure, comorbid conditions, and demographics. Bivariate and multivariable analyses were performed. Piperacillin-tazobactam-resistant\n            <jats:italic>P. aeruginosa<\/jats:italic>\n            was isolated from 179 patients, and piperacillin-tazobactam-susceptible\n            <jats:italic>P. aeruginosa<\/jats:italic>\n            was isolated from 624 patients over a 2.5-year period. Piperacillin-tazobactam (odds ratio [OR] = 6.82; 95% confidence interval [CI], 4.56 to 10.21), imipenem (OR = 2.42; 95% CI, 1.19 to 4.94), aminoglycosides (OR = 2.18; 95% CI, 1.44 to 3.28), vancomycin (OR = 1.87; 95% CI, 1.21 to 2.89), and broad-spectrum cephalosporins (OR = 2.38; 95% CI, 1.45 to 3.88) were the antibiotics associated with the isolation of piperacillin-tazobactam-resistant\n            <jats:italic>P. aeruginosa<\/jats:italic>\n            . Exposure to vancomycin (OR = 1.53; 95% CI, 1.13 to 2.06) or ampicillin-sulbactam (OR = 2.28; 95% CI, 1.62 to 3.21) was associated with recovery of piperacillin-tazobactam-susceptible\n            <jats:italic>P. aeruginosa<\/jats:italic>\n            . In this study, antibiotics associated with piperacillin-tazobactam-susceptible\n            <jats:italic>P. aeruginosa<\/jats:italic>\n            were different from antibiotics associated with piperacillin-tazobactam-resistant\n            <jats:italic>P. aeruginosa<\/jats:italic>\n            . Piperacillin-tazobactam was a strong risk factor for piperacillin-tazobactam-resistant\n            <jats:italic>P. aeruginosa<\/jats:italic>\n            . Our results suggest that the nosocomial isolation of piperacillin-tazobactam-resistant\n            <jats:italic>P. aeruginosa<\/jats:italic>\n            may be affected by multiple antibiotics.\n          <\/jats:p>","DOI":"10.1128\/aac.46.3.854-858.2002","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:56:57Z","timestamp":1027763817000},"page":"854-858","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":90,"title":["Risk Factors for Piperacillin-Tazobactam-Resistant\n            <i>Pseudomonas aeruginosa<\/i>\n            among Hospitalized Patients"],"prefix":"10.1128","volume":"46","author":[{"given":"Anthony D.","family":"Harris","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine"},{"name":"VA Maryland Health Care System, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eli","family":"Perencevich","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary-Claire","family":"Roghmann","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine"},{"name":"VA Maryland Health Care System, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith S.","family":"Kaye","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and International Health, Duke University Medical Center, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith A.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Maryland"},{"name":"VA Maryland Health Care System, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-6553(96)90026-7"},{"key":"e_1_3_2_3_2","first-page":"291","year":"2000","unstructured":"Chambers, H. F. 2000. Other B-lactam inhibitors, p. 291-299. In L. Mandell, J. E. Bennett, and R. Dolin (ed.), Principles and practice of infectious diseases. Churchill Livingstone, Philadelphia, Pa.","journal-title":"Principles and practice of infectious diseases"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(92)90133-8"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"10","DOI":"10.2307\/30146962","volume":"13","year":"1992","unstructured":"Gaynes, R. P., and D. H. Culver. 1992. Resistance to imipenem among selected gram-negative bacilli in the United States. Infect. Control Hosp. Epidemiol.13:10-14.","journal-title":"Infect. Control Hosp. 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