{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T16:19:30Z","timestamp":1694621970187},"reference-count":13,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2002,3,1]],"date-time":"2002-03-01T00:00:00Z","timestamp":1014940800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2002,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>Amoxicillin at doses of 0.2 to 5 mg\/kg of body weight was administered for the treatment of pneumococcal otitis media in a gerbil model. Doses greater than or equal to 2.5 mg\/kg, which resulted in concentrations in middle ear fluid of \u22651.4 \u03bcg\/ml and concentrations in serum higher than the MIC (1 \u03bcg\/ml) for \u226514% of the dosing interval, were both clinically and bacteriologically effective.<\/jats:p>","DOI":"10.1128\/aac.46.3.859-862.2002","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:56:57Z","timestamp":1027763817000},"page":"859-862","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":12,"title":["Optimal Dose of Amoxicillin in Treatment of Otitis Media Caused by a Penicillin-Resistant Pneumococcus Strain in the Gerbil Model"],"prefix":"10.1128","volume":"46","author":[{"given":"Araceli","family":"Parra","sequence":"first","affiliation":[{"name":"Departments of Medical Microbiology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Ponte","sequence":"additional","affiliation":[{"name":"Departments of Medical Microbiology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Cenjor","sequence":"additional","affiliation":[{"name":"Otolaryngology, Fundacio\u0301n Jime\u0301nez Di\u0301az"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gloria","family":"Garci\u0301a-Calvo","sequence":"additional","affiliation":[{"name":"Departments of Medical Microbiology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari\u0301a Jose\u0301","family":"Gime\u0301nez","sequence":"additional","affiliation":[{"name":"Medical Department, GlaxoSmithKline, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Aguilar","sequence":"additional","affiliation":[{"name":"Medical Department, GlaxoSmithKline, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Soriano","sequence":"additional","affiliation":[{"name":"Departments of Medical Microbiology"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1097\/00006454-199509000-00015","volume":"14","year":"1995","unstructured":"Brook, I., and P. Yocum. 1995. Bacteriology and beta-lactamase activity in ear aspirates of acute otitis media that failed amoxicillin therapy. Pediatr. Infect. Dis. J.14:805-808.","journal-title":"Pediatr. Infect. Dis. J."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/174.5.986"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1097\/00006454-199802000-00003","volume":"17","year":"1998","unstructured":"Castillo, F., F. Baquero-Artigao, and A. Garc\u00eda-Perea. 1998. Influence of recent antibiotic therapy on antimicrobial resistance of Streptococcus pneumoniae in children with acute otitis media in Spain. Pediatr. Infect. Dis. J.17:94-97.","journal-title":"Pediatr. Infect. Dis. J."},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199603000-00015"},{"key":"e_1_3_2_6_2","first-page":"1","volume":"18","year":"1999","unstructured":"Dowell, S. F., J. C. Butler, J. S. Giebink, M. R. Jacobs, D. Jernigan, D. M. Musher, A. 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Methods for dilution antimicrobial susceptibility test for bacteria that grow aerobically. Document M7-A4. National Committee for Clinical Laboratory Standards Wayne Pa."},{"key":"e_1_3_2_12_2","unstructured":"National Committee for Clinical Laboratory Standards. 1992. Methods for determining bactericidal activity of antimicrobial agents. Document M26-T. National Committee for Clinical Laboratory Standards Villanova Pa."},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/45.4.457"},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1086\/315237","volume":"181","year":"2000","unstructured":"Soriano, F., A. Parra, C. Cenjor, E. Nieto, G. Garc\u00eda-Calvo, M. J. Gim\u00e9nez, L. Aguilar, and C. Ponte. 2000. Role of Streptococcus pneumoniae and Haemophilus influenzae in the development of acute otitis media and otitis media with effusion in a gerbil model. J. Infect. Dis.181:646-652.","journal-title":"J. Infect. 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