{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:09:38Z","timestamp":1760242178422},"reference-count":16,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2002,4,1]],"date-time":"2002-04-01T00:00:00Z","timestamp":1017619200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2002,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            TEM-24 (CAZ-6) extended-spectrum \u03b2-lactamase (ESBL) was detected in 1988 in Clermont-Ferrand, France, in\n            <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n            (\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>TEM-24<\/jats:sub>\n            ) and\n            <jats:italic>Enterobacter aerogenes<\/jats:italic>\n            (\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>TEM-24b<\/jats:sub>\n            ), and since 1994, a TEM-24-producing\n            <jats:italic>E. aerogenes<\/jats:italic>\n            clonal strain has been observed elsewhere in the country. To determine if the spread of this clonal strain was restricted to TEM-24-producing\n            <jats:italic>E. aerogenes<\/jats:italic>\n            strains, 84\n            <jats:italic>E. aerogenes<\/jats:italic>\n            strains (non-TEM\/SHV-producing strains, TEM-1- or -2-producing strains, and different ESBL-producing strains), isolated from 1988 to 1999 in Clermont-Ferrand (\n            <jats:italic>n<\/jats:italic>\n            = 59) and in 11 other French hospitals in 1998 (\n            <jats:italic>n<\/jats:italic>\n            = 25), were studied. A clonal strain was found for TEM-24- but also for TEM-3- and TEM-1- or 2-producing isolates. This study shows that there is a clonal strain dependent on acquisition of the TEM-type enzyme (TEM-24 and other TEM types).\n          <\/jats:p>","DOI":"10.1128\/aac.46.4.1128-1131.2002","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:59:40Z","timestamp":1027763980000},"page":"1128-1131","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":32,"title":["TEM Derivative-Producing\n            <i>Enterobacter aerogenes<\/i>\n            Strains: Dissemination of a Prevalent Clone"],"prefix":"10.1128","volume":"46","author":[{"given":"P.","family":"Dumarche","sequence":"first","affiliation":[{"name":"Faculte\u0301 de Me\u0301decine, Laboratoire de Bacte\u0301riologie, 63001 Clermont-Ferrand Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"De Champs","sequence":"additional","affiliation":[{"name":"Faculte\u0301 de Me\u0301decine, Laboratoire de Bacte\u0301riologie, 63001 Clermont-Ferrand Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Sirot","sequence":"additional","affiliation":[{"name":"Faculte\u0301 de Me\u0301decine, Laboratoire de Bacte\u0301riologie, 63001 Clermont-Ferrand Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Chanal","sequence":"additional","affiliation":[{"name":"Faculte\u0301 de Me\u0301decine, Laboratoire de Bacte\u0301riologie, 63001 Clermont-Ferrand Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Bonnet","sequence":"additional","affiliation":[{"name":"Faculte\u0301 de Me\u0301decine, Laboratoire de Bacte\u0301riologie, 63001 Clermont-Ferrand Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Sirot","sequence":"additional","affiliation":[{"name":"Faculte\u0301 de Me\u0301decine, Laboratoire de Bacte\u0301riologie, 63001 Clermont-Ferrand Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.31.5.1055-1059.1993"},{"key":"e_1_3_2_3_2","first-page":"1513","volume":"24","year":"1979","unstructured":"Birnboim, H. 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E. F. Fritsch and T. Maniatis. 1989. Molecular cloning: a laboratory manual 2nd ed. vol. 1. 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