{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T11:31:09Z","timestamp":1770291069260,"version":"3.49.0"},"reference-count":18,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2002,5,1]],"date-time":"2002-05-01T00:00:00Z","timestamp":1020211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2002,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            It is not uncommon to see amphotericin B treatment failure in patients with systemic infection caused by\n            <jats:italic>Candida lusitaniae<\/jats:italic>\n            . We report a patient with stage IV ovarian carcinoma and\n            <jats:italic>C. lusitaniae<\/jats:italic>\n            sepsis whose treatment with amphotericin B failed. The initial blood isolate was susceptible to amphotericin B in vitro; however, the MIC for a blood isolate recovered 7 weeks after treatment began showed a fourfold increase. Direct subculture of two positive blood samples obtained within a week of the patient's death showed the coexistence of two distinct colony color variants on CHROMagar Candida (CAC). One variant was susceptible to amphotericin B, and one was resistant. These results emphasize the importance of repeat amphotericin B susceptibility testing for patients with persistent\n            <jats:italic>C. lusitaniae<\/jats:italic>\n            infection. The presence of colony variants on CAC may signal the emergence of amphotericin B resistance in\n            <jats:italic>C. lusitaniae<\/jats:italic>\n            and should be investigated.\n          <\/jats:p>","DOI":"10.1128\/aac.46.5.1325-1328.2002","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:09:01Z","timestamp":1027764541000},"page":"1325-1328","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":34,"title":["Change in Colony Morphology of\n            <i>Candida lusitaniae<\/i>\n            in Association with Development of Amphotericin B Resistance"],"prefix":"10.1128","volume":"46","author":[{"given":"Nancy B.","family":"McClenny","sequence":"first","affiliation":[{"name":"Clinical Microbiology\/Virology Laboratory"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haihua","family":"Fei","sequence":"additional","affiliation":[{"name":"Department of Pathology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen J.","family":"Baron","sequence":"additional","affiliation":[{"name":"Clinical Microbiology\/Virology Laboratory"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana C.","family":"Gales","sequence":"additional","affiliation":[{"name":"Stanford University Medical Center, Stanford, California 94305, and University of Iowa College of Medicine, Iowa City, Iowa 52242"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison","family":"Houston","sequence":"additional","affiliation":[{"name":"Stanford University Medical Center, Stanford, California 94305, and University of Iowa College of Medicine, Iowa City, Iowa 52242"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J.","family":"Hollis","sequence":"additional","affiliation":[{"name":"Stanford University Medical Center, Stanford, California 94305, and University of Iowa College of Medicine, Iowa City, Iowa 52242"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A.","family":"Pfaller","sequence":"additional","affiliation":[{"name":"Stanford University Medical Center, Stanford, California 94305, and University of Iowa College of Medicine, Iowa City, Iowa 52242"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.27.2.236-240.1989"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1097\/00006454-198708000-00013","volume":"6","year":"1987","unstructured":"Christenson, J. C., A. Guruswamy, G. Mukwaya, and P. Rettig. 1987. Candida lusitaniae: an emerging human pathogen. Pediatr. Infect. Dis. J.6:755-757.","journal-title":"Pediatr. Infect. Dis. J."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.18.2.443-444.1983"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/9.5.1006"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.8.4.462"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.33.6.1467-1470.1995"},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1099\/00222615-42-5-372","volume":"42","year":"1995","unstructured":"Mathaba, L. T., G. Davis, and J. R. Warminton. 1995. The genotypic relationship of Candida albicans strains isolated from the oral cavity of patients with denture stomatitis. J. Med. Microbiol.42:372-379.","journal-title":"J. Med. Microbiol."},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1099\/13500872-140-5-1195"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/168.2.502"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.20.6.1194-1195.1984"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.30.2.449-454.1992"},{"key":"e_1_3_2_13_2","unstructured":"National Committee for Clinical Laboratory Standards. 1997. Reference method for broth dilution antifungal susceptibility testing of yeasts. M-27A. National Committee for Clinical Laboratory Standards Wayne Pa."},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.32.8.1923-1929.1994"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.16.2.123"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0732-8893(94)90106-6"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(88)90059-9"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.30.11.3005-3008.1992"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.4.836"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.46.5.1325-1328.2002","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.46.5.1325-1328.2002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T17:52:58Z","timestamp":1645465978000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.46.5.1325-1328.2002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,5]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2002,5]]}},"alternative-id":["10.1128\/AAC.46.5.1325-1328.2002"],"URL":"https:\/\/doi.org\/10.1128\/aac.46.5.1325-1328.2002","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,5]]},"assertion":[{"value":"2001-06-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-10-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2002-05-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}