{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:52:11Z","timestamp":1791215531851,"version":"4.1.0"},"reference-count":36,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2002,5,1]],"date-time":"2002-05-01T00:00:00Z","timestamp":1020211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2002,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            To determine the epidemiologic features and clinical outcomes of bloodstream infections caused by extended-spectrum \u03b2-lactamase (ESBL)-producing\n            <jats:italic>Escherichia coli<\/jats:italic>\n            and\n            <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n            isolates, cases of bacteremia caused by these organisms in children were analyzed retrospectively. Among the 157 blood isolates recovered from 1993 to 1998 at the Seoul National University Children's Hospital, the prevalence of ESBL production was 17.9% among the\n            <jats:italic>E. coli<\/jats:italic>\n            isolates and 52.9% among the\n            <jats:italic>K. pneumoniae<\/jats:italic>\n            isolates. The commonest ESBLs were SHV-2a and TEM-52. A novel ESBL, TEM-88, was identified. Pulsed-field gel electrophoresis analysis of the ESBL-producing organisms showed extensive diversity in clonality. The medical records of 142 episodes were reviewed. The risk factors for bloodstream infection with ESBL-producing organisms were prior hospitalization, prior use of oxyimino-cephalosporins, and admission to an intensive care unit within the previous month. There was no difference in clinical severity between patients infected with ESBL-producing strains (the ESBL group) and those infected with ESBL-nonproducing strains (the non-ESBL group) at the time of presentation. However, the overall fatality rate for the ESBL group was significantly higher than that for the non-ESBL group: 12 of 45 (26.7%) versus 5 of 87 (5.7%) (\n            <jats:italic>P<\/jats:italic>\n            = 0.001). In a subset analysis of patients treated with extended-spectrum cephalosporins with or without an aminoglycoside, favorable response rates were significantly higher in the non-ESBL group at the 3rd day (6 of 17 versus 33 of 51;\n            <jats:italic>P<\/jats:italic>\n            = 0.035), the 5th day (6 of 17 versus 36 of 50;\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.05), and the end of therapy (9 of 17 versus 47 of 50;\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.001). In conclusion, the ESBL production of the infecting organisms has a significant impact on the clinical course and survival of pediatric patients with bacteremia caused by\n            <jats:italic>E. coli<\/jats:italic>\n            and\n            <jats:italic>K. pneumoniae<\/jats:italic>\n            .\n          <\/jats:p>","DOI":"10.1128\/aac.46.5.1481-1491.2002","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:09:01Z","timestamp":1027764541000},"page":"1481-1491","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":243,"title":["Bloodstream Infections by Extended-Spectrum \u03b2-Lactamase-Producing\n            <i>Escherichia coli<\/i>\n            and\n            <i>Klebsiella pneumoniae<\/i>\n            in Children: Epidemiology and Clinical Outcome"],"prefix":"10.1128","volume":"46","author":[{"given":"Yun-Kyung","family":"Kim","sequence":"first","affiliation":[{"name":"Departments of Pediatrics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunjoo","family":"Pai","sequence":"additional","affiliation":[{"name":"Internal Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoan-Jong","family":"Lee","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics"},{"name":"Clinical Research Institute, Seoul National University Hospital, SeoulDepartments of"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-Eun","family":"Park","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun-Hwa","family":"Choi","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics"},{"name":"Clinical Research Institute, Seoul National University Hospital, SeoulDepartments of"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jungmin","family":"Kim","sequence":"additional","affiliation":[{"name":"Microbiology, Dankook University College of Medicine, Cheonan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Je-Hak","family":"Kim","sequence":"additional","affiliation":[{"name":"Institute of Science and Technology, Cheil Jedang Corporation, Ichon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eui-Chong","family":"Kim","sequence":"additional","affiliation":[{"name":"Clinical Pathology, Seoul National University College of Medicine"},{"name":"Clinical Research Institute, Seoul National University Hospital, SeoulDepartments of"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1042\/bj2760269","volume":"276","year":"1991","unstructured":"Ambler, R. 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