{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:23:42Z","timestamp":1773282222568,"version":"3.50.1"},"reference-count":11,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2002,5,1]],"date-time":"2002-05-01T00:00:00Z","timestamp":1020211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2002,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Six strains of staphylococci were exposed to levofloxacin, moxifloxacin, or trovafloxacin in an in vitro pharmacodynamic model under both aerobic and anaerobic conditions. Each agent demonstrated a rapid 3-log\n            <jats:sub>10<\/jats:sub>\n            kill versus susceptible isolates regardless of condition. Against clinical isolates with reduced susceptibility, regrowth occurred by 24 h and was frequently associated with further increases in MICs.\n          <\/jats:p>","DOI":"10.1128\/aac.46.5.1561-1563.2002","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:09:01Z","timestamp":1027764541000},"page":"1561-1563","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":14,"title":["Comparative Pharmacodynamics of Three Newer Fluoroquinolones versus Six Strains of Staphylococci in an In Vitro Model under Aerobic and Anaerobic Conditions"],"prefix":"10.1128","volume":"46","author":[{"given":"David H.","family":"Wright","sequence":"first","affiliation":[{"name":"University of Minnesota College of Pharmacy, Department of Experimental and Clinical Pharmacology, Minneapolis, Minnesota 55455"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brent W.","family":"Gunderson","sequence":"additional","affiliation":[{"name":"University of Minnesota College of Pharmacy, Department of Experimental and Clinical Pharmacology, Minneapolis, Minnesota 55455"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurie B.","family":"Hovde","sequence":"additional","affiliation":[{"name":"University of Minnesota College of Pharmacy, Department of Experimental and Clinical Pharmacology, Minneapolis, Minnesota 55455"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gigi H.","family":"Ross","sequence":"additional","affiliation":[{"name":"University of Minnesota College of Pharmacy, Department of Experimental and Clinical Pharmacology, Minneapolis, Minnesota 55455"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalid H.","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"University of Minnesota College of Pharmacy, Department of Experimental and Clinical Pharmacology, Minneapolis, Minnesota 55455"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C.","family":"Rotschafer","sequence":"additional","affiliation":[{"name":"University of Minnesota College of Pharmacy, Department of Experimental and Clinical Pharmacology, Minneapolis, Minnesota 55455"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/28.3.399"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/313915"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01966996"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.3.781-785.2001"},{"key":"e_1_3_2_6_2","first-page":"43","volume":"79","year":"1994","unstructured":"Morrissey, I., and J. T. Smith. 1994. The importance of oxygen in the killing of bacteria by ofloxacin and ciprofloxacin. Microbios79:43-53.","journal-title":"Microbios"},{"key":"e_1_3_2_7_2","unstructured":"National Committee for Clinical Laboratory Standards. 1997. Methods for dilution antimicrobial susceptibility testing for bacteria that grow aerobically 4th ed. Approved standard M7-A4. National Committee for Clinical Laboratory Standards Villanova Pa."},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S0891-5520(05)70260-9","volume":"14","year":"2000","unstructured":"O'Donnell, J. A., and S. P. Gelone. 2000. Antibacterial therapy. Fluoroquinolones. Infect. Dis. Clin. N. Am.14:489-513.","journal-title":"Infect. Dis. Clin. N. Am."},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0378-4347(98)00006-1","volume":"709","year":"1998","unstructured":"Wright, D. H., V. K. Herman, F. N. Konstantinides, and J. C. Rotschafer. 1998. Determination of quinolone antibiotics in growth media by reversed-phase high-performance liquid chromatography. J. Chromatogr.709:97-104.","journal-title":"J. Chromatogr."},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.37.6.1377"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.37.11.2454"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.2.507"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.46.5.1561-1563.2002","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.46.5.1561-1563.2002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T17:51:51Z","timestamp":1645465911000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.46.5.1561-1563.2002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,5]]},"references-count":11,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2002,5]]}},"alternative-id":["10.1128\/AAC.46.5.1561-1563.2002"],"URL":"https:\/\/doi.org\/10.1128\/aac.46.5.1561-1563.2002","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,5]]},"assertion":[{"value":"2001-10-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2002-02-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2002-05-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}