{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T03:57:54Z","timestamp":1770350274243,"version":"3.49.0"},"reference-count":14,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2002,5,1]],"date-time":"2002-05-01T00:00:00Z","timestamp":1020211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2002,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>In vitro antifungal susceptibility testing results of a new antifungal triazole, posaconazole (POS), were compared to results with amphotericin B (AMB), itraconazole (ITC), voriconazole (VRC), and fluconazole (FLC) against clinical agents of zygomycosis. The MICs of POS at which 50% and 90% of the isolates were inhibited were 0.25 and 4 \u03bcg\/ml, respectively. POS was significantly more active than VRC and FLC and slightly more active than ITC. The results suggest that POS has significant potential for clinical development against the zygomycetes.<\/jats:p>","DOI":"10.1128\/aac.46.5.1581-1582.2002","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:09:01Z","timestamp":1027764541000},"page":"1581-1582","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":308,"title":["In Vitro Activities of Posaconazole, Itraconazole, Voriconazole, Amphotericin B, and Fluconazole against 37 Clinical Isolates of Zygomycetes"],"prefix":"10.1128","volume":"46","author":[{"given":"Qiu N.","family":"Sun","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases (7811), Department of Medicine"},{"name":"Department of Dermatology, Beijing Union Medical University Hospital, Beijing, 100730, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annette W.","family":"Fothergill","sequence":"additional","affiliation":[{"name":"The Fungus Testing Laboratory, Department of Pathology, The University of Texas Health Science Center at San Antonio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dora I.","family":"McCarthy","sequence":"additional","affiliation":[{"name":"The Fungus Testing Laboratory, Department of Pathology, The University of Texas Health Science Center at San Antonio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael G.","family":"Rinaldi","sequence":"additional","affiliation":[{"name":"The Fungus Testing Laboratory, Department of Pathology, The University of Texas Health Science Center at San Antonio"},{"name":"Audie L. 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