{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T09:31:49Z","timestamp":1759483909819,"version":"3.30.1"},"reference-count":11,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2002,5,1]],"date-time":"2002-05-01T00:00:00Z","timestamp":1020211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2002,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>We investigated the susceptibilities of hyphal, mixed hyphal, ungerminated arthroconidial, and germinated arthroconidial populations of<jats:italic>Coccidioides immitis<\/jats:italic>to lipid formulations of amphotericin B and nystatin and their conventional preparations, utilizing the National Committee for Clinical Laboratory Standards M38-P broth macrodilution method. The differences in effects of the three different growth stages of the saprobic phase of<jats:italic>C. immitis<\/jats:italic>on the MIC\/minimum lethal concentration (MLC) ratio were not statistically significant for any of the antifungal agents tested. These results suggest that either inocula could be used for in vitro susceptibility studies with<jats:italic>C. immitis<\/jats:italic>.<\/jats:p>","DOI":"10.1128\/aac.46.5.1583-1585.2002","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:09:01Z","timestamp":1027764541000},"page":"1583-1585","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":8,"title":["In Vitro Activities of Free and Lipid Formulations of Amphotericin B and Nystatin against Clinical Isolates of<i>Coccidioides immitis<\/i>at Various Saprobic Stages"],"prefix":"10.1128","volume":"46","author":[{"given":"Gloria M.","family":"Gonza\u0301lez","sequence":"first","affiliation":[{"name":"Fungus Testing Laboratory, Department of Pathology, University of Texas Health Science Center at San Antonio"},{"name":"Departamento de Microbiologi\u0301a, Facultad de Medicina, Universidad Auto\u0301noma de Nuevo Leo\u0301n, Monterrey, Nuevo Leo\u0301n, Me\u0301xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolando","family":"Tijerina","sequence":"additional","affiliation":[{"name":"Departamento de Microbiologi\u0301a, Facultad de Medicina, Universidad Auto\u0301noma de Nuevo Leo\u0301n, Monterrey, Nuevo Leo\u0301n, Me\u0301xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deanna A.","family":"Sutton","sequence":"additional","affiliation":[{"name":"Fungus Testing Laboratory, Department of Pathology, University of Texas Health Science Center at San Antonio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Graybill","sequence":"additional","affiliation":[{"name":"Fungus Testing Laboratory, Department of Pathology, University of Texas Health Science Center at San Antonio"},{"name":"Audie L. 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