{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T02:55:00Z","timestamp":1771124100580,"version":"3.50.1"},"reference-count":15,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2002,5,1]],"date-time":"2002-05-01T00:00:00Z","timestamp":1020211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2002,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>Azithromycin concentrations in the tonsils of 56 pediatric patients, treated with 10 or 20 mg of the drug per kg of body weight for 3 days, were compared. Azithromycin levels in plasma and tonsil samples were determined up to 8.5 days after the last dose. The 20-mg\/kg regimen resulted in an improved tonsillar distribution of azithromycin, suggesting the achievement of enhanced therapeutic concentrations at infective sites of the upper respiratory tract.<\/jats:p>","DOI":"10.1128\/aac.46.5.1594-1596.2002","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:09:01Z","timestamp":1027764541000},"page":"1594-1596","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":15,"title":["Distribution of Azithromycin in Plasma and Tonsil Tissue after Repeated Oral Administration of 10 or 20 Milligrams per Kilogram in Pediatric Patients"],"prefix":"10.1128","volume":"46","author":[{"given":"Corrado","family":"Blandizzi","sequence":"first","affiliation":[{"name":"Division of Pharmacology and Chemotherapy, Department of Oncology, Transplants and Advanced Technologies in Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tecla","family":"Malizia","sequence":"additional","affiliation":[{"name":"Section of Microbiology, Department of Experimental Pathology, Medical Biotechnologies, Infectious Diseases and Epidemiology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Batoni","sequence":"additional","affiliation":[{"name":"Section of Microbiology, Department of Experimental Pathology, Medical Biotechnologies, Infectious Diseases and Epidemiology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilia","family":"Ghelardi","sequence":"additional","affiliation":[{"name":"Section of Microbiology, Department of Experimental Pathology, Medical Biotechnologies, Infectious Diseases and Epidemiology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Baschiera","sequence":"additional","affiliation":[{"name":"Division of Pharmacology and Chemotherapy, Department of Oncology, Transplants and Advanced Technologies in Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Bruschini","sequence":"additional","affiliation":[{"name":"Division of Otorhinolaryngology, University Hospital of Pisa, Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Senesi","sequence":"additional","affiliation":[{"name":"Section of Microbiology, Department of Experimental Pathology, Medical Biotechnologies, Infectious Diseases and Epidemiology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Campa","sequence":"additional","affiliation":[{"name":"Section of Microbiology, Department of Experimental Pathology, Medical Biotechnologies, Infectious Diseases and Epidemiology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Del Tacca","sequence":"additional","affiliation":[{"name":"Division of Pharmacology and Chemotherapy, Department of Oncology, Transplants and Advanced Technologies in Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-8579(01)00410-1"},{"key":"e_1_3_1_3_2","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/BF01699979","volume":"17","year":"1998","unstructured":"Cremer, J., C. 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