{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T15:33:29Z","timestamp":1759160009085},"reference-count":24,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2002,6,1]],"date-time":"2002-06-01T00:00:00Z","timestamp":1022889600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2002,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            A survey of the drug susceptibilities of gonococcal isolates from 100 consecutive patients attending clinics in the Tel Aviv area of Israel during the period from February to September 2000 has shown a 61% rate of ciprofloxacin resistance (MICs, \u22651 \u03bcg\/ml); 51 isolates were highly resistant (MICs, \u22654 \u03bcg\/ml). Ciprofloxacin-resistant strains were more prevalent among isolates with chromosomally mediated resistance to penicillin and tetracycline. Therapeutic failures with ciprofloxacin correlated with MICs of \u22651 mg\/ml (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.01). The high rate of ciprofloxacin resistance coinciding with a sharp rise in the incidence of gonorrhea precludes the use of fluoroquinolone drugs for the empirical treatment of gonococcal infections acquired in Israel.\n          <\/jats:p>","DOI":"10.1128\/aac.46.6.1671-1673.2002","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:09:29Z","timestamp":1027764569000},"page":"1671-1673","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":17,"title":["High Prevalence of High-Level Ciprofloxacin Resistance in\n            <i>Neisseria gonorrhoeae<\/i>\n            in Tel Aviv, Israel: Correlation with Response to Therapy"],"prefix":"10.1128","volume":"46","author":[{"given":"Michael","family":"Dan","sequence":"first","affiliation":[{"name":"Infectious Diseases Unit, E. Wolfson Hospital, Holon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Poch","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, E. Wolfson Hospital, Holon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bracha","family":"Sheinberg","sequence":"additional","affiliation":[{"name":"Central Laboratory, Maccabi Health Services, Rishon-le-Zion, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.4.1130-1136.1999"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.34.12.3214-3217.1996"},{"key":"e_1_3_1_4_2","first-page":"196","volume":"69","year":"1993","unstructured":"Bogaerts, J., W. M. Tello, J. Akingeneye, V. Mukantabana, E. Van Dyck, and P. Piot. 1993. 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Guidelines for treatment of sexually transmitted diseases. Morb. Mortal. Wkly. Rep.47(No. RR-1):59-60.","journal-title":"Morb. Mortal. Wkly. Rep."},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.36.2.277"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.36.8.1682"},{"key":"e_1_3_1_10_2","doi-asserted-by":"crossref","first-page":"158","DOI":"10.3201\/eid0701.010126","volume":"7","year":"2001","unstructured":"Dan, M., F. Poch, D. Spitz, and B. Sheinberg. 2001. High level ciprofloxacin resistance in Neisseria gonorrhoeae: first report from Israel. Emerg. Infect. Dis.7:158-159.","journal-title":"Emerg. Infect. Dis."},{"key":"e_1_3_1_11_2","unstructured":"Department of Epidemiology. 2001. Wkly. epidemiological report. 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