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In this study we show the leishmanicidal effect of the synthetic coronaridine and its racemic 18-methoxylated analog, 18-methoxycoronaridine. Both alkaloids revealed a potent leishmanicide effect against<jats:italic>Leishmania amazonensis<\/jats:italic>, a causative agent of cutaneous and diffuse cutaneous leishmaniasis in the New World. Despite their potent leishmanicide effect, both alkaloids were neither toxic to murine macrophages nor did they modulate their oxidative or cytokine production responses.<\/jats:p>","DOI":"10.1128\/aac.46.7.2111-2115.2002","type":"journal-article","created":{"date-parts":[[2002,7,28]],"date-time":"2002-07-28T23:07:23Z","timestamp":1027897643000},"page":"2111-2115","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":42,"title":["In Vitro Activities of Iboga Alkaloid Congeners Coronaridine and 18-Methoxycoronaridine against<i>Leishmania amazonensis<\/i>"],"prefix":"10.1128","volume":"46","author":[{"given":"Jan Carlo","family":"Delorenzi","sequence":"first","affiliation":[{"name":"Departamento de Imunologia, Instituto de Microbiologia"},{"name":"Instituto de Biofi\u0301sica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Freire-de-Lima","sequence":"additional","affiliation":[{"name":"Departamento de Imunologia, Instituto de Microbiologia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cerli R.","family":"Gattass","sequence":"additional","affiliation":[{"name":"Instituto de Biofi\u0301sica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deise","family":"de Andrade Costa","sequence":"additional","affiliation":[{"name":"Instituto de Biofi\u0301sica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwen","family":"He","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Vermont, Burlington, Vermont"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin E.","family":"Kuehne","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Vermont, Burlington, Vermont"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvira M. 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