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The in vitro MICs of posaconazole and itraconazole for the strains of<jats:italic>Mucor<\/jats:italic>spp. used in this study ranged from 0.125 to 8 \u03bcg\/ml and 0.25 to 8 \u03bcg\/ml, respectively. The in vitro MIC range for amphotericin B is 0.125 to 0.25 \u03bcg\/ml. At twice-daily doses of \u226515 mg\/kg of body weight, posaconazole prolonged the survival of the mice and reduced tissue burden.<\/jats:p>","DOI":"10.1128\/aac.46.7.2310-2312.2002","type":"journal-article","created":{"date-parts":[[2002,7,28]],"date-time":"2002-07-28T23:07:23Z","timestamp":1027897643000},"page":"2310-2312","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":162,"title":["In Vivo Activity of Posaconazole against<i>Mucor<\/i>spp. in an Immunosuppressed-Mouse Model"],"prefix":"10.1128","volume":"46","author":[{"given":"Qiu N.","family":"Sun","sequence":"first","affiliation":[{"name":"Division of Infectious Disease, Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229-3900"},{"name":"Department of Dermatology, Beijing Union Medical University Hospital, Beijing, 100730 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura K.","family":"Najvar","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease, Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229-3900"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosie","family":"Bocanegra","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease, Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229-3900"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Loebenberg","sequence":"additional","affiliation":[{"name":"Schering-Plough Research Institute, Kenilworth, New Jersey 07033-1300"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Graybill","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease, Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229-3900"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.36.10.2950-2956.1998"},{"key":"e_1_3_1_3_2","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1093\/jac\/48.6.919","volume":"48","year":"2001","unstructured":"Gomez-Lopez, A., M. 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