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In the Wistar rat spontaneous pneumonia model, both azasordarins significantly reduced the number of\n            <jats:italic>P. carinii<\/jats:italic>\n            cysts per gram of lung homogenate when administered at 1 mg\/kg of body weight twice a day for 10 days. In a nude rat inoculation model, both compounds showed therapeutic efficacy at 0.25 mg\/kg twice a day for 10 days.\n          <\/jats:p>","DOI":"10.1128\/aac.46.8.2648-2650.2002","type":"journal-article","created":{"date-parts":[[2002,7,28]],"date-time":"2002-07-28T23:07:23Z","timestamp":1027897643000},"page":"2648-2650","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":6,"title":["Therapeutic Efficacies of GW471552 and GW471558, Two New Azasordarin Derivatives, against Pneumocystosis in Two Immunosuppressed-Rat Models"],"prefix":"10.1128","volume":"46","author":[{"given":"Elena","family":"Jimenez","sequence":"first","affiliation":[{"name":"GlaxoSmithKline, Madrid"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Marti\u0301nez","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline, Madrid"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"El Moukhtar","family":"Aliouat","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitology, School of Pharmacy, Lille-II University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesus","family":"Caballero","sequence":"additional","affiliation":[{"name":"Laboratorios Hipra, Girona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Dei-Cas","sequence":"additional","affiliation":[{"name":"Lille-CHRU, Ecology of Parasitism, Institute Pasteur of Lille, Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domingo","family":"Gargallo-Viola","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline, Madrid"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0248-4900(05)80190-X"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"41S","DOI":"10.1111\/j.1550-7408.1997.tb05765.x","volume":"44","year":"1997","unstructured":"Aliouat, E. 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