{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:13:10Z","timestamp":1760782390434},"reference-count":26,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2002,8,1]],"date-time":"2002-08-01T00:00:00Z","timestamp":1028160000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2002,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The prevalence of antimicrobial resistance among 4,940 U.S. pneumococcal isolates collected during 1999 was as follows: penicillin, 16.2%; amoxicillin-clavulanate, 12.2%; cefuroxime, 28.1%; ceftriaxone, 3.6%; trimethoprim-sulfamethoxazole, 30.3%; azithromycin, 21.4%; levofloxacin, 0.6%; and moxifloxacin, 0.1%. Compared to the previous 1997-1998 study (Jones et al., Antimicrob. Agents Chemother.\n            <jats:bold>44:<\/jats:bold>\n            2645-2652, 2000), increases were noted for resistance to penicillin (3.7%;\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.001), amoxicillin-clavulanate (3.9%;\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.001), cefuroxime (5.7%;\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.001), azithromycin (2.4%;\n            <jats:italic>P<\/jats:italic>\n            = 0.014), trimethoprim-sulfamethoxazole (15.4%;\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.001), and levofloxacin (0.3%;\n            <jats:italic>P<\/jats:italic>\n            = 0.017). Resistance to ceftriaxone (0.1%;\n            <jats:italic>P<\/jats:italic>\n            = 0.809) and moxifloxacin (0.03%;\n            <jats:italic>P<\/jats:italic>\n            = 0.570) decreased. Concurrently, multidrug resistance increased (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.001) from 6.3% to 11.3%.\n          <\/jats:p>","DOI":"10.1128\/aac.46.8.2651-2655.2002","type":"journal-article","created":{"date-parts":[[2002,7,28]],"date-time":"2002-07-28T23:07:23Z","timestamp":1027897643000},"page":"2651-2655","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":22,"title":["Longitudinal Assessment of Antipneumococcal Susceptibility in the United States"],"prefix":"10.1128","volume":"46","author":[{"given":"Mark E.","family":"Jones","sequence":"first","affiliation":[{"name":"Focus Technologies, Inc., 1217 KP Hilversum, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A.","family":"Karlowsky","sequence":"additional","affiliation":[{"name":"Focus Technologies, Inc., Herndon, Virginia 20171"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rene\u0301e","family":"Blosser-Middleton","sequence":"additional","affiliation":[{"name":"Focus Technologies, Inc., Herndon, Virginia 20171"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian A.","family":"Critchley","sequence":"additional","affiliation":[{"name":"Focus Technologies, Inc., Herndon, Virginia 20171"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Karginova","sequence":"additional","affiliation":[{"name":"Focus Technologies, Inc., Herndon, Virginia 20171"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clyde","family":"Thornsberry","sequence":"additional","affiliation":[{"name":"Focus Technologies, Inc., Franklin, Tennessee, 37064"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel F.","family":"Sahm","sequence":"additional","affiliation":[{"name":"Focus Technologies, Inc., Herndon, Virginia 20171"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199512143332408"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199907223410403"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.2.550-555.2002"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.1.119-124.2002"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0506.990603"},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1086\/514953","volume":"27","year":"1998","unstructured":"Doern, G. 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