{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T13:17:54Z","timestamp":1791033474040,"version":"4.1.0"},"reference-count":26,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2002,9,1]],"date-time":"2002-09-01T00:00:00Z","timestamp":1030838400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2002,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Two putative proteins (NorMI and NorMII) similar to the multidrug efflux protein NorM of\n            <jats:italic>Vibrio parahaemolyticus<\/jats:italic>\n            are encoded by the\n            <jats:italic>Brucella melitensis<\/jats:italic>\n            16 M genome. We show that a drug-hypersusceptible\n            <jats:italic>Escherichia coli<\/jats:italic>\n            strain overexpressing NorMI displays increased resistance to norfloxacin, ciprofloxacin, gentamicin, tetraphenylphosphonium ion, acriflavine, and berberine. This elevated resistance was proven to be mediated by an energy-dependent efflux mechanism. NorMI belongs to the multidrug and toxic compound extrusion family and is the first multidrug efflux protein identified in\n            <jats:italic>Brucella<\/jats:italic>\n            spp.\n          <\/jats:p>","DOI":"10.1128\/aac.46.9.3050-3053.2002","type":"journal-article","created":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T19:36:19Z","timestamp":1033500979000},"page":"3050-3053","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":38,"title":["Functional Characterization of\n            <i>Brucella melitensis<\/i>\n            NorMI, an Efflux Pump Belonging to the Multidrug and Toxic Compound Extrusion Family"],"prefix":"10.1128","volume":"46","author":[{"given":"Martine","family":"Braibant","sequence":"first","affiliation":[{"name":"Unite\u0301 de Pathologie Infectieuse et Immunologie, Institut National de la Recherche Agronomique, 37380 Nouzilly, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Guilloteau","sequence":"additional","affiliation":[{"name":"Unite\u0301 de Pathologie Infectieuse et Immunologie, Institut National de la Recherche Agronomique, 37380 Nouzilly, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel S.","family":"Zygmunt","sequence":"additional","affiliation":[{"name":"Unite\u0301 de Pathologie Infectieuse et Immunologie, Institut National de la Recherche Agronomique, 37380 Nouzilly, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/25.2.302"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.36.1.150"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1093\/tropej\/47.1.60","volume":"47","year":"2001","unstructured":"Bannatyne, R. 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