{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:19:20Z","timestamp":1760887160306},"reference-count":10,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2002,9,1]],"date-time":"2002-09-01T00:00:00Z","timestamp":1030838400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2002,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The in vitro and in vivo activities of DW286, a novel fluoronaphthyridone with potent antibacterial activity, were compared with those of ciprofloxacin, gemifloxacin, sparfloxacin, and trovafloxacin. Against gram-positive bacteria, such as\n            <jats:italic>Staphylococcus aureus<\/jats:italic>\n            ,\n            <jats:italic>Staphylococcus epidermidis<\/jats:italic>\n            ,\n            <jats:italic>Streptococcus pneumoniae<\/jats:italic>\n            , and\n            <jats:italic>Enterococcus faecalis<\/jats:italic>\n            , the in vitro activity of DW286 was stronger than that of any other reference antibiotic. Against gram-negative bacteria, the activity of DW286 was similar to those of trovafloxacin and gemifloxacin but was weaker than that of ciprofloxacin. In a mouse systemic infection caused by three\n            <jats:italic>S. aureus<\/jats:italic>\n            strains, including methicillin-resistant\n            <jats:italic>S. aureus<\/jats:italic>\n            and quinolone-resistant\n            <jats:italic>S. aureus<\/jats:italic>\n            (QRSA), DW286 demonstrated the most potent activity, as found in vitro. Specially, DW286 is \u22658-fold more active against QRSA than the other fluoroquinolones. And the 50% protective doses for DW286 were correspondent with the in vitro activities.\n          <\/jats:p>","DOI":"10.1128\/aac.46.9.3071-3074.2002","type":"journal-article","created":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T19:36:19Z","timestamp":1033500979000},"page":"3071-3074","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":25,"title":["In Vitro and In Vivo Antibacterial Activities of DW286, a New Fluoronaphthyridone Antibiotic"],"prefix":"10.1128","volume":"46","author":[{"given":"Hee-Jeong","family":"Yun","sequence":"first","affiliation":[{"name":"College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 151-742"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Hong","family":"Min","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 151-742"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung-A","family":"Lim","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 151-742"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Wook","family":"Kang","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 151-742"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"So-Young","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 151-742"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mi-Jeong","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 151-742"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae-Hee","family":"Jeong","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 151-742"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-Jeong","family":"Choi","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 151-742"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun-Jin","family":"Kwon","sequence":"additional","affiliation":[{"name":"Dong-Wha Pharmaceutical Ind. Co., Ltd., Anyang, Kyonggi 430-017"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Ho","family":"Jung","sequence":"additional","affiliation":[{"name":"Dong-Wha Pharmaceutical Ind. Co., Ltd., Anyang, Kyonggi 430-017"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mi-Ja","family":"Shim","sequence":"additional","affiliation":[{"name":"Department of Life Science, The University of Seoul, Seoul 130-743, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eung-Chil","family":"Choi","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 151-742"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-8579(00)00192-8"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jac.a020889"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1093\/jac\/39.4.509","volume":"39","year":"1997","unstructured":"Choi, K. H., J. S. Hong, S. K. Kim, D. K. Lee, S. J. Yoon, and E. C. Choi. 1997. In-vitro and in-vivo activities of DW-116, a new fluoroquinolone. J. Antimicrob. Chemother.39:509-514.","journal-title":"J. Antimicrob. Chemother."},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/45.4.437"},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1093\/jac\/47.5.681","volume":"47","year":"2001","unstructured":"Garcia-Garrote, F., E. Cercenado, J. Martin-Pedroviejo, O. Cuevas, and E. Bouza. 2001. Comparative in vitro activity of the new quinolone gemifloxacin (SB-265805) with other fluoroquinolones against respiratory tract pathogens. J. Antimicrob. Chemother.47:681-684.","journal-title":"J. Antimicrob. Chemother."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.10.2209"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.3.673-678.2001"},{"key":"e_1_3_2_9_2","first-page":"99","volume":"96","year":"1949","unstructured":"Litchfield, J. T., and F. Wilcoxon. 1949. Simplified method of evaluating dose-effect experiments. J. Pharmacol. Exp. Ther.96:99-113.","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_3_2_10_2","unstructured":"Lorian V. 1996. Antibiotics in laboratory medicine 4th ed. p. 635-636. Williams & Wilkins Baltimore Md."},{"key":"e_1_3_2_11_2","unstructured":"National Committee for Clinical Laboratory Standards. 1997. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically 4th ed. Approved standard M7-A4. National Committee for Clinical Laboratory Standards Wayne Pa."}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.46.9.3071-3074.2002","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.46.9.3071-3074.2002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T17:46:10Z","timestamp":1645465570000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.46.9.3071-3074.2002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,9]]},"references-count":10,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2002,9]]}},"alternative-id":["10.1128\/AAC.46.9.3071-3074.2002"],"URL":"https:\/\/doi.org\/10.1128\/aac.46.9.3071-3074.2002","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,9]]},"assertion":[{"value":"2001-12-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2002-05-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2002-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}