{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:33:49Z","timestamp":1790901229129,"version":"4.1.0"},"reference-count":48,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2003,11,1]],"date-time":"2003-11-01T00:00:00Z","timestamp":1067644800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2003,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            In 1999, 39 of 2,599 isolates of the family\n            <jats:italic>Enterobacteriaceae<\/jats:italic>\n            (1.5%) collected by eight private laboratories in the Aquitaine region in France produced an extended-spectrum \u03b2-lactamase (ESBL). Among these were 19\n            <jats:italic>Enterobacter aerogenes<\/jats:italic>\n            isolates; 8\n            <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n            isolates; 6\n            <jats:italic>Escherichia coli<\/jats:italic>\n            isolates; 3\n            <jats:italic>Proteus mirabilis<\/jats:italic>\n            isolates; and 1 isolate each of\n            <jats:italic>Serratia marcescens<\/jats:italic>\n            ,\n            <jats:italic>Morganella morganii<\/jats:italic>\n            , and\n            <jats:italic>Providencia stuartii<\/jats:italic>\n            . ESBL producers were isolated from 38 patients, including 33 residents of 11 clinics or nursing homes and 5 ambulatory patients. Seven different ESBLs were characterized. These mainly consisted of TEM-24 (25 isolates) and TEM-21 (9 isolates), but TEM-15 (2 isolates) and TEM-3, TEM-19, SHV-4, and CTX-M-1 (1 isolate each) were also characterized. Seven strains showed the coexistence of different TEM- and\/or SHV-encoding genes, including a new SHV-1 variant, SHV-44, defined by the substitution R205L previously reported for SHV-3 in association with S238G. The epidemiology of the ESBL producers was investigated by random amplification of polymorphic DNA, typing by enterobacterial repetitive intergenic consensus PCR, analysis of resistance cotransferred with the ESBL, and analysis of the restriction profiles of the ESBL-encoding plasmids. Of the TEM-24-expressing strains, 18 were\n            <jats:italic>E. aerogenes<\/jats:italic>\n            isolates, including 9 from the same clinic, that were representatives of the epidemic clone disseminating in France. Of the TEM-21-producing strains that belonged to different species of the family\n            <jats:italic>Enterobacteriaceae<\/jats:italic>\n            (\n            <jats:italic>E. coli<\/jats:italic>\n            ,\n            <jats:italic>K. pneumoniae<\/jats:italic>\n            , and\n            <jats:italic>P. mirabilis<\/jats:italic>\n            ), 8 were isolated in the same nursing home. Outbreaks due to strain and\/or plasmid dissemination in these clinic and nursing home were demonstrated. The presence of ESBL producers in five ambulatory patients probably resulted from nosocomial acquisition. Our data highlight the serious need to monitor patients for ESBL-producing\n            <jats:italic>Enterobacteriaceae<\/jats:italic>\n            in general practice.\n          <\/jats:p>","DOI":"10.1128\/aac.47.11.3506-3514.2003","type":"journal-article","created":{"date-parts":[[2003,10,24]],"date-time":"2003-10-24T02:33:30Z","timestamp":1066962810000},"page":"3506-3514","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":115,"title":["Extended-Spectrum \u03b2-Lactamase-Producing\n            <i>Enterobacteriaceae<\/i>\n            in Community and Private Health Care Centers"],"prefix":"10.1128","volume":"47","author":[{"given":"Corinne","family":"Arpin","sequence":"first","affiliation":[{"name":"Laboratoire de Microbiologie, Universite\u0301 de Bordeaux 2, 33076 Bordeaux Cedex"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ve\u0301ronique","family":"Dubois","sequence":"additional","affiliation":[{"name":"Laboratoire de Microbiologie, Universite\u0301 de Bordeaux 2, 33076 Bordeaux Cedex"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Coulange","sequence":"additional","affiliation":[{"name":"Laboratoire de Microbiologie, Universite\u0301 de Bordeaux 2, 33076 Bordeaux Cedex"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Andre\u0301","sequence":"additional","affiliation":[{"name":"Laboratoire de Microbiologie, Universite\u0301 de Bordeaux 2, 33076 Bordeaux Cedex"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Fischer","sequence":"additional","affiliation":[{"name":"Laboratoires d'Analyses Me\u0301dicales, 33000 Bordeaux"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Noury","sequence":"additional","affiliation":[{"name":"Laboratoire d'Analyses Me\u0301dicales, 33140 Villenave d'Ornon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fre\u0301de\u0301ric","family":"Grobost","sequence":"additional","affiliation":[{"name":"Laboratoire d'Analyses Me\u0301dicales, 64000 Bayonne"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Philippe","family":"Brochet","sequence":"additional","affiliation":[{"name":"Laboratoires d'Analyses Me\u0301dicales, 33000 Bordeaux"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Jullin","sequence":"additional","affiliation":[{"name":"Laboratoires d'Analyses Me\u0301dicales, 33000 Bordeaux"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Dutilh","sequence":"additional","affiliation":[{"name":"Laboratoires d'Analyses Me\u0301dicales, 33000 Bordeaux"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilberte","family":"Larribet","sequence":"additional","affiliation":[{"name":"Laboratoire d'Analyses Me\u0301dicales, 33160 St Me\u0301dard-en-Jalles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Lagrange","sequence":"additional","affiliation":[{"name":"Laboratoire d\u2019Analyses Me\u0301dicales, 16000 Angoule\u030cme, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudine","family":"Quentin","sequence":"additional","affiliation":[{"name":"Laboratoire de Microbiologie, Universite\u0301 de Bordeaux 2, 33076 Bordeaux Cedex"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2760269"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.32.10.2553-2558.1994"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.34.9.2163-2169.1996"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.9.2480-2485.2001"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.5.1183-1189.2002"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268899003908"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2510073"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.2.509"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01708236"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/7.6.1513"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.8.2269-2275.2001"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.7.2165-2169.1999"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.6.1211"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0732-8893(98)00113-8"},{"key":"e_1_3_2_16_2","unstructured":"Courvalin P. 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