{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:42:45Z","timestamp":1792114965347,"version":"4.4.0"},"reference-count":15,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2003,11,1]],"date-time":"2003-11-01T00:00:00Z","timestamp":1067644800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2003,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Five sequential\n            <jats:italic>Cryptococcus neoformans<\/jats:italic>\n            isolates recovered from an AIDS patient with recurrent meningitis were analyzed. Four isolates were fluconazole susceptible, while the fifth isolate developed fluconazole resistance. Analysis of the 14-\u03b1 lanosterol demethylase gene (\n            <jats:italic>ERG11<\/jats:italic>\n            ) showed a point mutation in the resistant strain responsible for the amino acid substitution G484S.\n          <\/jats:p>","DOI":"10.1128\/aac.47.11.3653-3656.2003","type":"journal-article","created":{"date-parts":[[2003,10,24]],"date-time":"2003-10-24T02:33:30Z","timestamp":1066962810000},"page":"3653-3656","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":134,"title":["G484S Amino Acid Substitution in Lanosterol 14-\u03b1 Demethylase (\n            <i>ERG11<\/i>\n            ) Is Related to Fluconazole Resistance in a Recurrent\n            <i>Cryptococcus neoformans<\/i>\n            Clinical Isolate"],"prefix":"10.1128","volume":"47","author":[{"given":"Laura","family":"Rodero","sequence":"first","affiliation":[{"name":"Departamento Micologi\u0301a, Instituto Nacional de Enfermedades Infecciosas, ANLIS \u201cDr. Carlos G. 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