{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T01:59:31Z","timestamp":1792202371302,"version":"4.4.0"},"reference-count":21,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2003,12,1]],"date-time":"2003-12-01T00:00:00Z","timestamp":1070236800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2003,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The\nantimalarial activity of artemether following oral or intramuscular\nadministration in the plasma of 15 adults with acute uncomplicated\n            <jats:italic>Plasmodium falciparum<\/jats:italic>\n            malaria was measured by bioassay. The\npeak concentrations in plasma following oral administration were higher\nin patients with acute illness (median, 1,905 mmol of\ndihydroartemisinin [DHA] equivalents per liter; range, 955 to\n3,358 mmol of DHA equivalents per liter) than in patients in the\nconvalescent phase (median, 955 mmol of DHA equivalents per liter;\nrange, 576 to 1,363 mmol of DHA equivalents per liter), and clearance\n(CL\/F) was lower in patients in the acute phase (1.11 liters\/kg\/h;\nrange, 0.21 to 3.08 liters\/kg\/h) than in patients in the convalescent\nphase (median, 2.76 liters\/kg\/h; range, 1.56 to 5.74 liters\/kg\/h)\n(\n            <jats:italic>P<\/jats:italic>\n            \u2264 0.008). Antimalarial activity in terms of the\npeak concentration in plasma (\n            <jats:italic>C<\/jats:italic>\n            <jats:sub>max<\/jats:sub>\n            ) after oral\nadministration was a median of 16 times higher than that after\nintramuscular administration. The ratio of the area under the plasma\nconcentration-time curve during the first 24 h\n(AUC\n            <jats:sub>0-24<\/jats:sub>\n            ) after oral administration of artemether to the\nAUC\n            <jats:sub>0-24<\/jats:sub>\n            after intramuscular administration was a median of\n3.3 (range, 1 to 11) (\n            <jats:italic>P<\/jats:italic>\n            = 0.0001). In the acute phase,\nthe time to\n            <jats:italic>C<\/jats:italic>\n            <jats:sub>max<\/jats:sub>\n            was significantly shorter after\noral administration (median, 1 h; range, 0.5 to 3.0\nh) than after intramuscular administration (median, 8 h;\nrange, 4 to 24 h) (\n            <jats:italic>P<\/jats:italic>\n            = 0.001). Intramuscular\nartemether is absorbed very slowly in patients with acute\nmalaria.\n          <\/jats:p>","DOI":"10.1128\/aac.47.12.3795-3798.2003","type":"journal-article","created":{"date-parts":[[2003,11,24]],"date-time":"2003-11-24T22:53:35Z","timestamp":1069714415000},"page":"3795-3798","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":35,"title":["Artemether Bioavailability after Oral or IntramuscularAdministration in Uncomplicated FalciparumMalaria"],"prefix":"10.1128","volume":"47","author":[{"given":"Kamolrat","family":"Silamut","sequence":"first","affiliation":[{"name":"Faculty\rof Tropical Medicine, Mahidol\rUniversity"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul N.","family":"Newton","sequence":"additional","affiliation":[{"name":"Faculty\rof Tropical Medicine, Mahidol\rUniversity"},{"name":"Centre for Tropical\rMedicine, Nuffield Department of Clinical Medicine, John\rRadcliffe Hospital, Headington, Oxford, United\rKingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paktiya","family":"Teja-Isavadharm","sequence":"additional","affiliation":[{"name":"Department of Immunology and\rMedicine, Armed Forces Research Institute of Medical\rSciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yupin","family":"Suputtamongkol","sequence":"additional","affiliation":[{"name":"Department of Medicine,\rSiriraj Hospital, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duangsuda","family":"Siriyanonda","sequence":"additional","affiliation":[{"name":"Department of Immunology and\rMedicine, Armed Forces Research Institute of Medical\rSciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maneerat","family":"Rasameesoraj","sequence":"additional","affiliation":[{"name":"Department of Immunology and\rMedicine, Armed Forces Research Institute of Medical\rSciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasithon","family":"Pukrittayakamee","sequence":"additional","affiliation":[{"name":"Faculty\rof Tropical Medicine, Mahidol\rUniversity"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"White","sequence":"additional","affiliation":[{"name":"Faculty\rof Tropical Medicine, Mahidol\rUniversity"},{"name":"Centre for Tropical\rMedicine, Nuffield Department of Clinical Medicine, John\rRadcliffe Hospital, Headington, Oxford, United\rKingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","unstructured":"Anonymous. 1998\n. 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