{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:17:55Z","timestamp":1791177475357,"version":"4.1.0"},"reference-count":43,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2003,12,1]],"date-time":"2003-12-01T00:00:00Z","timestamp":1070236800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2003,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>The\nupsurge of multiple-drug-resistant microbes warrants the development\nand\/or use of effective antibiotics. Triclosan, though used in cosmetic\nand dermatological preparations for several decades, has not been used\nas a systemic antibacterial agent due to problems of drug\nadministration. Here we report the striking efficacy of triclosan in a\nmouse model of acute systemic bacterial infection. Triclosan not only\nsignificantly extends the survival time of the infected mice, it also\nrestores blood parameters and checks liver damage induced by the\nbacterial infection. We believe that the excellent safety track record\nof triclosan in topical use coupled with our findings qualifies\ntriclosan as a candidate drug or lead compound for exploring its\npotential in experimental systems for treating systemic bacterial\ninfections.<\/jats:p>","DOI":"10.1128\/aac.47.12.3859-3866.2003","type":"journal-article","created":{"date-parts":[[2003,11,24]],"date-time":"2003-11-24T22:53:35Z","timestamp":1069714415000},"page":"3859-3866","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":32,"title":["Triclosan as a Systemic Antibacterial Agent in a MouseModel of Acute BacterialChallenge"],"prefix":"10.1128","volume":"47","author":[{"given":"Shilpi","family":"Sharma","sequence":"first","affiliation":[{"name":"Molecular\rBiophysics Unit, Indian Institute of Science, Bangalore 560\r012"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. N. C.","family":"Ramya","sequence":"additional","affiliation":[{"name":"Molecular\rBiophysics Unit, Indian Institute of Science, Bangalore 560\r012"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avadhesha","family":"Surolia","sequence":"additional","affiliation":[{"name":"Molecular\rBiophysics Unit, Indian Institute of Science, Bangalore 560\r012"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namita","family":"Surolia","sequence":"additional","affiliation":[{"name":"Jawaharlal Nehru\rCentre for Advanced Scientific Research, Jakkur, Bangalore 560\r064, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-6553(96)90017-6"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/26.5.551"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/26.5.555"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BFb0027661"},{"key":"e_1_3_2_6_2","first-page":"185","volume":"2","year":"1989","unstructured":"DeSalva, S. 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