{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T02:12:35Z","timestamp":1767924755431,"version":"3.49.0"},"reference-count":17,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2003,12,1]],"date-time":"2003-12-01T00:00:00Z","timestamp":1070236800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2003,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            We\nhave evaluated the efficacy of voriconazole (VRC) in a murine model of\nsystemic infection by\n            <jats:italic>Scedosporium apiospermum<\/jats:italic>\n            . The survival\nof mice treated with VRC at 5, 20, or 40 mg\/kg\/day was greater than\nthat of the control group (\n            <jats:italic>P<\/jats:italic>\n            \u2264 0.0009). VRC reduced\nthe tissue burden in the spleen and brain (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.001\nin both organs) in comparison with that of the control\ngroup.\n          <\/jats:p>","DOI":"10.1128\/aac.47.12.3976-3978.2003","type":"journal-article","created":{"date-parts":[[2003,11,24]],"date-time":"2003-11-24T22:53:35Z","timestamp":1069714415000},"page":"3976-3978","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":53,"title":["Efficacyof Voriconazole in Treatment of Systemic Scedosporiosis inNeutropenicMice"],"prefix":"10.1128","volume":"47","author":[{"given":"Javier","family":"Capilla","sequence":"first","affiliation":[{"name":"Unitat\rde Microbiologia, Facultat de Medicina, Universitat Rovira i Virgili,\rReus, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Serena","sequence":"additional","affiliation":[{"name":"Unitat\rde Microbiologia, Facultat de Medicina, Universitat Rovira i Virgili,\rReus, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. Javier","family":"Pastor","sequence":"additional","affiliation":[{"name":"Unitat\rde Microbiologia, Facultat de Medicina, Universitat Rovira i Virgili,\rReus, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montserrat","family":"Ortoneda","sequence":"additional","affiliation":[{"name":"Unitat\rde Microbiologia, Facultat de Medicina, Universitat Rovira i Virgili,\rReus, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep","family":"Guarro","sequence":"additional","affiliation":[{"name":"Unitat\rde Microbiologia, Facultat de Medicina, Universitat Rovira i Virgili,\rReus, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/11.6.890"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/02681219280000571"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.7.2151-2153.2001"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010954803886"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-199818040-00002"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.36.5.1436-1438.1998"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/mmy.40.3.243.248"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg261"},{"key":"e_1_3_2_10_2","first-page":"176","volume":"43","year":"1998","unstructured":"Horr\u00e9, R., and G. S. de Hoog. 1998. Primary cerebral infections by melanized fungi: a review. Stud. Mycol.43:176-193.","journal-title":"Stud. Mycol."},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkf103"},{"key":"e_1_3_2_12_2","first-page":"62","volume":"42","year":"2002","unstructured":"Meletiadis, J., J. F. Meis, J. W. Mouton, J. L. Rodr\u00edguez-Tudela, J. P. Donnelly, and P. E. Verweij. 2002. In vitro activities of new and conventional antifungal agents against clinical Scedosporium isolates. Antimicrob. Agents Chemother.42:62-68.","journal-title":"Antimicrob. Agents Chemother."},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1086\/317496"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1086\/314042"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-51-11-924"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/mmy.38.3.209.212"},{"key":"e_1_3_2_17_2","first-page":"601","volume":"45","year":"2000","unstructured":"Sugar, A. M., and X.-P. Liu. 2000. Efficacy of voriconazole in treatment of murine pulmonary blastomycosis.Antimicrob. Agents Chemother.45:601-604.","journal-title":"Antimicrob. Agents Chemother."},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200203000-00015"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.47.12.3976-3978.2003","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.47.12.3976-3978.2003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T17:43:30Z","timestamp":1645465410000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.47.12.3976-3978.2003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,12]]},"references-count":17,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2003,12]]}},"alternative-id":["10.1128\/AAC.47.12.3976-3978.2003"],"URL":"https:\/\/doi.org\/10.1128\/aac.47.12.3976-3978.2003","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,12]]},"assertion":[{"value":"2003-04-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2003-08-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2003-12-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}