{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T13:42:49Z","timestamp":1780407769835,"version":"3.54.1"},"reference-count":18,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2003,2,1]],"date-time":"2003-02-01T00:00:00Z","timestamp":1044057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2003,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            A novel glycylcycline agent, tigecycline (GAR-936), was evaluated in vivo in the mouse model of peritonitis against three\n            <jats:italic>Enterococcus faecalis<\/jats:italic>\n            and four\n            <jats:italic>Enterococcus faecium<\/jats:italic>\n            isolates with different susceptibilities to vancomycin and tetracyclines, all of which were inhibited by \u22640.125 \u03bcg of tigecycline\/ml. Using a single subcutaneous dose, tigecycline displayed a protective effect (50% protective dose, \u22645.7 mg\/kg of body weight) against all strains tested, including two with Tn\n            <jats:italic>925<\/jats:italic>\n            (from the Tn\n            <jats:italic>916<\/jats:italic>\n            family), which contains the Tet(M) tetracycline resistance determinant, as well as VanA and VanB strains. As expected, tetracycline and minocycline were ineffective against the isolates carrying Tn\n            <jats:italic>925<\/jats:italic>\n            .\n          <\/jats:p>","DOI":"10.1128\/aac.47.2.529-532.2003","type":"journal-article","created":{"date-parts":[[2003,1,23]],"date-time":"2003-01-23T21:05:59Z","timestamp":1043355959000},"page":"529-532","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":30,"title":["Activity of Tigecycline (GAR-936), a Novel Glycylcycline, against Enterococci in the Mouse Peritonitis Model"],"prefix":"10.1128","volume":"47","author":[{"given":"Esteban C.","family":"Nannini","sequence":"first","affiliation":[{"name":"Center for the Study of Emerging and Re-Emerging Pathogens"},{"name":"Division of Infectious Diseases, Department of Internal Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh R.","family":"Pai","sequence":"additional","affiliation":[{"name":"Center for the Study of Emerging and Re-Emerging Pathogens"},{"name":"Division of Infectious Diseases, Department of Internal Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kavindra V.","family":"Singh","sequence":"additional","affiliation":[{"name":"Center for the Study of Emerging and Re-Emerging Pathogens"},{"name":"Division of Infectious Diseases, Department of Internal Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara E.","family":"Murray","sequence":"additional","affiliation":[{"name":"Center for the Study of Emerging and Re-Emerging Pathogens"},{"name":"Division of Infectious Diseases, Department of Internal Medicine"},{"name":"Department of Microbiology and Molecular Genetics, The University of Texas Medical School, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1067\/mic.2001.119952"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.62.12.5587-5594.1994"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.8.2225-2229.2000"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1097\/00006454-199812000-00011","volume":"17","year":"1998","unstructured":"Das, I., and J. 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