{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T01:08:55Z","timestamp":1784941735354,"version":"3.55.0"},"reference-count":26,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2003,2,1]],"date-time":"2003-02-01T00:00:00Z","timestamp":1044057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2003,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Five\n            <jats:italic>Listeria monocytogenes<\/jats:italic>\n            isolates (CLIP 21369, CLIP 73298, CLIP 74811, CLIP 75679, and CLIP 79372) were found to be resistant to fluoroquinolones during the screening for antibiotic resistance of 488\n            <jats:italic>L. monocytogenes<\/jats:italic>\n            isolates from human cases of listeriosis in France. On the basis of a fourfold or greater decrease in the ciprofloxacin MIC in the presence of reserpine, fluoroquinolone resistance was attributed to active efflux of the drugs. The\n            <jats:italic>lde<\/jats:italic>\n            gene (\n            <jats:italic>Listeria<\/jats:italic>\n            drug efflux; formerly\n            <jats:italic>lmo2741<\/jats:italic>\n            ) encodes a 12-transmembrane-segment putative efflux pump belonging to the major facilitator superfamily of secondary transporters that displayed 44% identity with PmrA from\n            <jats:italic>Streptococcus pneumoniae<\/jats:italic>\n            . Insertional inactivation of the\n            <jats:italic>lde<\/jats:italic>\n            gene in CLIP 21369 indicated that the corresponding protein was responsible for fluoroquinolone resistance and was involved in the level of susceptibility to dyes such as ethidium bromide and acridine orange.\n          <\/jats:p>","DOI":"10.1128\/aac.47.2.704-708.2003","type":"journal-article","created":{"date-parts":[[2003,1,23]],"date-time":"2003-01-23T21:05:59Z","timestamp":1043355959000},"page":"704-708","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":122,"title":["Efflux Pump Lde Is Associated with Fluoroquinolone Resistance in\n            <i>Listeria monocytogenes<\/i>"],"prefix":"10.1128","volume":"47","author":[{"given":"Sylvain","family":"Godreuil","sequence":"first","affiliation":[{"name":"Unite\u0301 des Agents Antibacte\u0301riens"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Galimand","sequence":"additional","affiliation":[{"name":"Unite\u0301 des Agents Antibacte\u0301riens"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Gerbaud","sequence":"additional","affiliation":[{"name":"Unite\u0301 des Agents Antibacte\u0301riens"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Jacquet","sequence":"additional","affiliation":[{"name":"Laboratoire des Listeria, Institut Pasteur, 75724 Paris Cedex 15, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Courvalin","sequence":"additional","affiliation":[{"name":"Unite\u0301 des Agents Antibacte\u0301riens"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.9.2103"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.181.11.3368-3374.1999"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/mr.55.3.476-511.1991"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.1.187"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1063447"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-1605(00)00501-8"},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1086\/517384","volume":"177","year":"1998","unstructured":"Guillemot, D., P. Maison, C. Carbon, B. Balkau, F. Vauzelle-Kervro\u00ebdan, C. Sermet, G. Bouvenot, and E. Eschw\u00e8ge. 1998. Trends in antimicrobial drug use in the community\u2014France, 1981-1992. J. Infect. Dis.177:492-497.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1007\/BF01992167","volume":"12","year":"1993","unstructured":"Hadorn, K., H. H\u00e4chler, A. Schaffner, and F. H. Kayser. 1993. Genetic characterization of plasmid-encoded multiple antibiotic resistance in a strain of Listeria monocytogenes causing endocarditis. Eur. Clin. Microbiol. Infect. Dis.12:928-937.","journal-title":"Eur. Clin. Microbiol. Infect. 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