{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:35:56Z","timestamp":1791423356800,"version":"4.3.3"},"reference-count":13,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2003,3,1]],"date-time":"2003-03-01T00:00:00Z","timestamp":1046476800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2003,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            We investigated a possible synergistic effect of a macrolide and \u03b2-lactams against\n            <jats:italic>Streptococcus pneumoniae<\/jats:italic>\n            strains with different resistance profiles. Checkerboard and time-kill assays of erythromycin combined with penicillin or cefotaxime essentially showed indifference, suggesting that these antibiotics in combinations in vitro act substantially as individuals in their activity against\n            <jats:italic>S. pneumoniae<\/jats:italic>\n            .\n          <\/jats:p>","DOI":"10.1128\/aac.47.3.1151-1153.2003","type":"journal-article","created":{"date-parts":[[2003,2,25]],"date-time":"2003-02-25T18:22:21Z","timestamp":1046197341000},"page":"1151-1153","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":32,"title":["Lack of Synergy of Erythromycin Combined with Penicillin or Cefotaxime against\n            <i>Streptococcus pneumoniae<\/i>\n            In Vitro"],"prefix":"10.1128","volume":"47","author":[{"given":"Eugene","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Medicine, Marshall University School of Medicine, Huntington, West Virginia 25701-3655"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald J.","family":"Stanek","sequence":"additional","affiliation":[{"name":"Department of Medicine, Marshall University School of Medicine, Huntington, West Virginia 25701-3655"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurice A.","family":"Mufson","sequence":"additional","affiliation":[{"name":"Department of Medicine, Marshall University School of Medicine, Huntington, West Virginia 25701-3655"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","first-page":"1","volume":"44","year":"1999","unstructured":"Amsden, G. 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