{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T16:14:08Z","timestamp":1694621648203},"reference-count":29,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2003,5,1]],"date-time":"2003-05-01T00:00:00Z","timestamp":1051747200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2003,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The relationship between virulence and chromosomal elements containing glycopeptide resistance genes was experimentally assessed for two transconjugant strains of\n            <jats:italic>Enterococcus faecalis<\/jats:italic>\n            (VanA and VanB phenotypes) and compared to that for a susceptible wild-type strain. Microbiologic and inflammatory effects were assessed in a polymicrobial rat model of peritonitis. Mean peritoneal enterococcus concentrations \u00b1 standard deviations at day 1 were 2.1 \u00b1 1.9, 1.3 \u00b1 1.1, and 1.7 \u00b1 2.0 log\n            <jats:sub>10<\/jats:sub>\n            CFU\/ml for susceptible, VanA, and VanB strains, respectively (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.05). At day 3 also there were lower concentrations of glycopeptide-resistant enterococcal strains in peritoneal fluid (3.2 \u00b1 3.4, 1.8 \u00b1 1.8, and 2.1 \u00b1 2.4 log\n            <jats:sub>10<\/jats:sub>\n            CFU\/ml for susceptible, VanA, and VanB strains, respectively [\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.05]). Transconjugant glycopeptide-resistant strains were associated with increased peritoneal cell counts at the different evaluation times of the experiment (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.001). Plasma \u03b11-acid glycoprotein concentrations were lower in the presence of the susceptible strain (667 \u00b1 189 mg\/liter) than in the presence of the VanA or VanB strain (1,193 \u00b1 419 or 1,210 \u00b1 404 mg\/liter, respectively [\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.05]), while concentrations of tumor necrosis factor alpha and interleukin-6 in peritoneal fluid remained similar for the strains. These results suggest a trend toward variation of virulence of transconjugant strains compared to the wild-type strain in this peritonitis model.\n          <\/jats:p>","DOI":"10.1128\/aac.47.5.1560-1564.2003","type":"journal-article","created":{"date-parts":[[2003,4,22]],"date-time":"2003-04-22T21:03:23Z","timestamp":1051045403000},"page":"1560-1564","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":5,"title":["Impact of Elements Containing Glycopeptide Resistance Genes on Expression of Virulence in\n            <i>Enterococcus faecalis<\/i>\n            Peritonitis: a Pilot Study with Rats"],"prefix":"10.1128","volume":"47","author":[{"given":"G.","family":"Plantefeve","sequence":"first","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, EMI 9933"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Dupont","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, EMI 9933"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Hubert","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, EMI 9933"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Garry","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, EMI 9933"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Pou\u0308s","sequence":"additional","affiliation":[{"name":"Service de Biochimie A, Ho\u0302pital Bichat-Claude Bernard, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Carbon","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, EMI 9933"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Montravers","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, EMI 9933"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1369-5274(99)00005-3"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.37.8.1563"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.179.1.97-106.1997"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.59.12.4614-4620.1991"},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0022-1759(84)90293-X","volume":"74","year":"1984","unstructured":"Biou, D., M. 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