{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T20:58:41Z","timestamp":1793134721835,"version":"4.5.0"},"reference-count":23,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2003,6,1]],"date-time":"2003-06-01T00:00:00Z","timestamp":1054425600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2003,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The activities of linezolid, an oxazolidinone antibacterial agent active against gram-positive organisms, alone and in combination with 35 antimicrobial agents were tested in vitro against methicillin-sensitive (<jats:italic>n<\/jats:italic>= 1 to 2 strains) and methicillin-resistant (<jats:italic>n<\/jats:italic>= 8 to 10)<jats:italic>Staphylococcus aureus<\/jats:italic>strains; vancomycin-sensitive (<jats:italic>n<\/jats:italic>= 6) and vancomycin-resistant (<jats:italic>n<\/jats:italic>= 6 to 8)<jats:italic>Enterococcus faecalis<\/jats:italic>strains; vancomycin-sensitive (<jats:italic>n<\/jats:italic>= 5) and vancomycin-resistant (<jats:italic>n<\/jats:italic>= 6)<jats:italic>Enterococcus faecium<\/jats:italic>strains; penicillin-sensitive (<jats:italic>n<\/jats:italic>= 2 to 5), penicillin-intermediate (<jats:italic>n<\/jats:italic>= 5 to 6), and penicillin-resistant (<jats:italic>n<\/jats:italic>= 5 to 6)<jats:italic>Streptococcus pneumoniae<\/jats:italic>strains;<jats:italic>Escherichia coli<\/jats:italic>(<jats:italic>n<\/jats:italic>= 6); and<jats:italic>Klebsiella pneumoniae<\/jats:italic>(<jats:italic>n<\/jats:italic>= 6). The fractional inhibitory concentration indices of linezolid in combination with other antimicrobial agents for the organisms tested were generated on checkerboard broth microdilution plates prepared by a semiautomated method. Of 1,380 organism-drug combinations, 1,369 (99.2%) combinations of linezolid with 28 antimicrobial drugs were indifferent, 9 combinations (0.65%) of linezolid with 6 drugs (amoxicillin, erythromycin, imipenem, sparfloxacin, teicoplanin, and tetracycline) were synergistic, and 2 combinations (0.15%) of linezolid with 2 drugs (ofloxacin and sparfloxacin) were antagonistic. Overall, the in vitro data demonstrated that linezolid combined with other antimicrobial agents primarily produces an indifferent response, with infrequent occurrences of synergism and antagonism.<\/jats:p>","DOI":"10.1128\/aac.47.6.1902-1906.2003","type":"journal-article","created":{"date-parts":[[2003,5,21]],"date-time":"2003-05-21T21:28:09Z","timestamp":1053552489000},"page":"1902-1906","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":73,"title":["In Vitro Activities of Linezolid Combined with Other Antimicrobial Agents against Staphylococci, Enterococci, Pneumococci, and Selected Gram-Negative Organisms"],"prefix":"10.1128","volume":"47","author":[{"given":"Michael T.","family":"Sweeney","sequence":"first","affiliation":[{"name":"Infectious Diseases Biology, Pharmacia Corporation, Kalamazoo, Michigan 49007"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary E.","family":"Zurenko","sequence":"additional","affiliation":[{"name":"Infectious Diseases Biology, Pharmacia Corporation, Kalamazoo, Michigan 49007"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.8.2602-2605.2002"},{"key":"e_1_3_1_3_2","unstructured":"American Society for Microbiology. 2002. 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