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Doses of 15, 25, and 50 mg\/kg of body weight\/day for the new triazole albaconazole (ABC) were evaluated in an immunocompetent rabbit model of systemic infection with this mold. Treatments were begun 1 day after challenge and given for 10 days. ABC at any dose was more effective than amphotericin B (AMB) at 0.8 mg\/kg\/day at clearing<jats:italic>S. prolificans<\/jats:italic>from tissue (<jats:italic>P<\/jats:italic>&lt; 0.007). The percentages of survival at 25 mg of ABC\/kg\/day were similar to those obtained with AMB. Rabbits showed 100% survival when they were treated with 50 mg of ABC per kg (<jats:italic>P<\/jats:italic>&lt; 0.0001 versus control group), and only this dosage was able to reduce tissue burden significantly in the five organs studied, i.e., spleen, kidneys, liver, lungs, and brain.<\/jats:p>","DOI":"10.1128\/aac.47.6.1948-1951.2003","type":"journal-article","created":{"date-parts":[[2003,5,21]],"date-time":"2003-05-21T21:28:09Z","timestamp":1053552489000},"page":"1948-1951","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":45,"title":["Efficacy of Albaconazole (UR-9825) in Treatment of Disseminated<i>Scedosporium prolificans<\/i>Infection in Rabbits"],"prefix":"10.1128","volume":"47","author":[{"given":"Javier","family":"Capilla","sequence":"first","affiliation":[{"name":"Unitat de Microbiologia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara","family":"Yustes","sequence":"additional","affiliation":[{"name":"Unitat de Microbiologia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emili","family":"Mayayo","sequence":"additional","affiliation":[{"name":"Unitat de Anatomia Patolo\u0300gica, Facultat de Medicina, Universitat Rovira i Virgili, Reus"},{"name":"Servei Patologia, Hospital Universitari de Tarragona Joan XXIII, Tarragona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Belkys","family":"Ferna\u0301ndez","sequence":"additional","affiliation":[{"name":"Unitat de Microbiologia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montserrat","family":"Ortoneda","sequence":"additional","affiliation":[{"name":"Unitat de Microbiologia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Javier Pastor","sequence":"additional","affiliation":[{"name":"Unitat de Microbiologia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep","family":"Guarro","sequence":"additional","affiliation":[{"name":"Unitat de Microbiologia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1021\/jm9707277","volume":"41","year":"1998","unstructured":"Bartol\u00ed, J., E. 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